Results 61 to 70 of about 39,677 (245)
ESC Heart Failure, Volume 12, Issue 2, Page 1416-1426, April 2025.Abstract Aims SPARCL1 was recently identified as a biomarker of right ventricular (RV) maladaptation in patients with pulmonary hypertension (PH), and N‐terminal pro‐brain natriuretic protein (NT‐proBNP) is an established biomarker of RV failure in PH. The present study investigated whether NT‐proBNP and SPARCL1 concentrations are associated with load ...
Oliver Dörr +15 more
wiley +1 more source
Rack1 Binds HIV-1 Nef and Can Act as a Nef–Protein Kinase C Adaptor [PDF]
, 2001 Nef proteins of primate immunodeficiency viruses exert pleiotropic effects, such as enhanced endocytosis of CD4 and MHC-I cell surface molecules, perturbation of signal transduction cascades, and virion infectivity enhancement.
Rossi, F., Milanesi, G., Gallina, A.
core +1 more source
ELECTROPHORESIS, EarlyView.Lentiviral vector purification using QA CIM monolith anion‐exchange chromatography was optimized via 96‐well and DOE, increasing recovery from 20% to 90%. The process achieved 3.3‐log host cell protein reduction, decreased particle impurities, and showed high binding capacity, supporting large‐scale manufacturing.
Luka Bevc +7 more
wiley +1 more source
HIV-1 Myristoylated Nef Treatment of Murine Microglial Cells Activates Inducible Nitric Oxide Synthase, NO2 Production and Neurotoxic Activity. [PDF]
PLoS ONE, 2015 The potential role of the human immunodeficiency virus-1 (HIV-1) accessory protein Nef in the pathogenesis of neuroAIDS is still poorly understood.
Giorgio Mangino +12 more
doaj +1 more source
HIV-1 Nef is released in extracellular vesicles derived from astrocytes: Evidence for Nef-mediated neurotoxicity [PDF]
, 2017 © The Author(s) 2017. Human immunodeficiency virus-Associated neurological disorders (HANDs) affect the majority of AIDS patients and are a significant problem among HIV-1-infected individuals who live longer because of combined anti-retroviral therapies.
Cicalese, S +5 more
core +1 more source
International Studies of Economics, EarlyView.Abstract This paper examines the link between climate risk, energy consumption, and financial market performance in a sample of emerging countries over the period 2000–2024. The objective is to model the dynamic interactions between these three dimensions, in order to understand the extent to which energy dependence and exposure to climate risks ...
Abdelkader Mohamed Derbali
wiley +1 more source
A Highly Conserved Residue in HIV-1 Nef Alpha Helix 2 Modulates Protein Expression
mSphere, 2016 Extensive genetic diversity is a defining characteristic of human immunodeficiency virus type 1 (HIV-1) and poses a significant barrier to the development of an effective vaccine.
Aaron L. Johnson +6 more
doaj +1 more source
Master recherche Histoire du monde méditerranéen médiéval, 2020 Annliese Nef est maîtresse de conférences depuis 2012 à Paris 1, habilitée à diriger des recherches. Elle est spécialiste d’histoire de l’Occident islamique et de la Sicile médiévale (IXe-XIIIe siècle), et des processus d’islamisation aux premiers siècles de l’Islam. Elle a notamment publié avec H. Bresc, Al-Idrîsî, La première géographie de l’Occident,
openaire +1 more source
HIV-1 Nef Stabilizes the Association of Adaptor Protein Complexes with Membranes
, 2003 The maximal virulence of HIV-1 requires Nef, a virally encoded peripheral membrane protein. Nef binds to the adaptor protein (AP) complexes of coated vesicles, inducing an expansion of the endosomal compartment and altering the surface expression of ...
Douglas Hitchin +19 more
core +1 more source