Results 81 to 90 of about 1,307 (146)

Direct binding to GABARAP family members is essential for HIV-1 Nef plasma membrane localization

Scientific Reports, 2017
HIV-1 Nef is an important pathogenic factor for HIV/AIDS pathogenesis. Studies have shown that the association of Nef with the inner leaflet of the plasma membrane and with endocytic and perinuclear vesicles is essential for most activities of Nef. Using
Alexandra Boeske, Melanie Schwarten, Peixiang Ma, Markus Tusche, Jessica Mötter, Christina Möller, Philipp Neudecker, Silke Hoffmann, Dieter Willbold   +8 more
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Neferine inhibits vascular smooth muscle cell proliferation and migration in atherosclerosis by targeting CYS130 and PHE252 in PTEN

Frontiers in Pharmacology
IntroductionThe abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) are significant pathological factors contributing to atherosclerosis (AS).
Qi Jin, Qi Jin, Qi Jin, Qingqing Liu, Chenghao Ruan, Chenghao Ruan, Chenghao Ruan, Zhen Xie, Zhen Xie, Zhen Xie, Xinzhi Gao, Xinzhi Gao, Xinzhi Gao, Yanyan Jiang, Yanyan Jiang, Yanyan Jiang, Fei Jiang, Fei Jiang, Fei Jiang, Baoping Xie, Baoping Xie, Baoping Xie   +21 more
doaj   +1 more source

Nef-specific CD8+ T cell responses contribute to HIV-1 immune control.

PLoS ONE, 2013
Recent studies in the SIV-macaque model of HIV infection suggest that Nef-specific CD8+ T-cell responses may mediate highly effective immune control of viraemia.
Emily Adland, Jonathan M Carlson, Paolo Paioni, Henrik Kløverpris, Roger Shapiro, Anthony Ogwu, Lynn Riddell, Graz Luzzi, Fabian Chen, Thambiah Balachandran, David Heckerman, Anette Stryhn, Anne Edwards, Thumbi Ndung'u, Bruce D Walker, Søren Buus, Philip Goulder, Philippa C Matthews   +17 more
doaj   +1 more source

The Effects of Heat Shock Proteins on Delivery of HIV-1 Nef Antigen in Mammalian Cells

Vaccine Research, 2020
Introduction: Vaccine design is mainly considered as a therapeutic strategy to elicit HIV-specific immunity. DNA vaccines encoding an antigen and also an adjuvant can induce an effective adaptive immunity. Due to having numerous roles in viral infection,
Alireza Milani, Fatemeh Rouhollah, Maryam Naseroleslami, Azam Bolhassani   +3 more
doaj  

HIV‐1 Nef is carried on the surface of extracellular vesicles

Journal of Extracellular Vesicles
Extracellular vesicles (EVs) serve as pivotal mediators of intercellular communication in both health and disease, delivering biologically active molecules from vesicle‐producing cells to recipient cells.
Christophe Vanpouille, Beda Brichacek, Tatiana Pushkarsky, Larisa Dubrovsky, Wendy Fitzgerald, Nigora Mukhamedova, Sofia Garcia‐Hernandez, Doreen Matthies, Anastas Popratiloff, Dmitri Sviridov, Leonid Margolis, Michael Bukrinsky   +11 more
doaj   +1 more source

Genetic determinants of HIV-1 subtype C Nef-mediated SERINC3 down-regulation

Virology Journal
Background Nef-mediated down-regulation of the host restriction factors SERINC3 and SERINC5 significantly enhances HIV-1 infectivity. Natural Nef polymorphisms that affect SERINC3 down-regulation are not as well-characterised as those that affect SERINC5
Nikeisha Samlall, Tarylee Reddy, Nasreen Ismail, Mark A. Brockman, Zabrina L. Brumme, Thumbi Ndung’u, Jaclyn K. Mann   +6 more
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On nef subvarieties

Advances in Mathematics, 2019
The goal of this work is to study positivity of subvarieties with nef normal bundle in the sense of intersection theory. After Ottem's work on ample subschemes, we introduce the notion of a nef subscheme, which generalizes the notion of a subvariety with nef normal bundle. We show that restriction of a pseudoeffective (resp.
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La priorale Saint-Pierre de Souvigny (Allier) : étude archéologique de la nef, seconde tranche

Bulletin du Centre d’Études Médiévales d’Auxerre, 2008
Pascale Chevalier, Sébastien Bully, Morana Čaušević-Bully, Mathias Dupuis, Laurent Fiocchi, Audrey Baradat   +5 more
doaj   +1 more source

HIV-1 Nef synergizes with APOL1-G1 to induce nephrocyte cell death in HIV-related kidney diseases

Disease Models & Mechanisms
Jun-yi Zhu, Yulong Fu, Joyce van de Leemput, Jing Yu, Jinliang Li, Patricio E. Ray, Zhe Han   +6 more
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NEF Protein [PDF]

, 2020
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