Results 191 to 200 of about 13,075 (222)

The HIV-1 nef gene product is associated with phosphorylation of a 46 kD cellular protein

AIDS, 1992
To study the biochemical properties of the HIV-1 nef gene product.Earlier reports suggested that Nef protein is phosphorylated and has kinase activity. These properties were examined using an in vitro translated product.A DNA fragment encoding Nef of HIV-1SF2 was transcribed in vitro under the control of T7 promoter.
L, Poulin, J A, Levy
openaire   +2 more sources

Intrahost and Interhost Variability of the HIV Type 1 nef Gene in Brazilian Children

AIDS Research and Human Retroviruses, 2009
Many aspects of HIV-1 pathogenesis are affected by Nef protein activity, and efforts have been made to study variation in the nef gene and how that variation relates to disease outcome. We studied the genetic diversity of the nef gene in distinct clones obtained from the same patient (intrahost) and in sequences obtained from different hosts (interhost)
Cavalieri, Elizabeth UNIFESP, Florido, Camila UNIFESP, Leal, Elcio UNIFESP, Machado, Daisy Maria UNIFESP, Camargo, Michelle UNIFESP, Diaz, Ricardo S. UNIFESP, Janini, Luiz Mario UNIFESP   +6 more
openaire   +3 more sources

Control of human immunodeficiency virus replication by the tat, rev, nef and protease genes

Current Opinion in Immunology, 1991
Immediately after infection, human immunodeficiency virus directs the synthesis of three regulatory proteins tat, rev and nef that together allow the synthesis of the structural proteins of the virus after a delay of several hours. Viral mRNA production is controlled by the tat gene, which appears to stimulate elongation by RNA polymerase II, and the ...
openaire   +2 more sources

Characterization and signature pattern analysis of Korean clade HIV-1 using nef gene sequences

The Journal of Microbiology, 2008
Phylogenetic studies of the HIV-1 gene sequences isolated from Korean patients have suggested that most of Korean isolates belong to the subtype B strain. This study aims to characterize the Korean clade by molecular phylogenetic analysis using all of the Korean nef gene sequences registered in the NCBI GenBank (N=422), in addition to 41 reference ...
Chan Seung, Park, Dong Hun, Lee, Keon Myung, Lee, Chan-Hee, Lee   +3 more
openaire   +2 more sources

Sequence Analysis of Neuroinvasive and Blood-Derived HIV-1 nef Genes

1995
Neurological disease associated with acquired immune deficiency syndrome (AIDS) relates to the presence of human immunodeficiency virus-1 (HIV-1) in the central nervous system (CNS). In support, HIV-1, like other lentiviruses, invades the CNS and can be readily isolated from cerebrospinal fluid (CSF) and brain of HIV-infected individuals.
Ruth Brack-Werner, Thomas Görblich, Thomas Werner, Francesca Chiodi, Lutz Gürtler, Josef Eberle, Annemarie Schön, Volker Erfle   +7 more
openaire   +1 more source

The HIV-1 nef gene product

Biochemical Society Transactions, 1992
M, Harris, S, Talbot, P, Patsilinacos, J C, Neil   +3 more
openaire   +2 more sources

Nef Modulation of HIV Type 1 Gene Expression and Cytopathicity in Tissues of HIV Transgenic Mice

AIDS Research and Human Retroviruses, 2000
Transgenic mice bearing HIV-1 proviral DNA deleted in the gag/pol region (HIVd1443 mice) model a chronic, nonproductive form of viral gene expression in various cell types including macrophages. They display a disease phenotype that includes HIV-associated nephropathy (HIVAN), congenital cataracts, papillomatosis, and growth failure.
openaire   +2 more sources

On the HIV nef gene product

Research in Virology, 1992
openaire   +2 more sources

The nef gene products: biochemical properties and effects on host cell functions

Research in Virology, 1992
A R, Nebreda, F, Segade, E, Santos
openaire   +2 more sources

[HIV nef gene and nef protein].

Nihon rinsho. Japanese journal of clinical medicine, 1994
K, Obaru, S, Matsushita, K, Takatsuki
openaire   +1 more source