Results 251 to 260 of about 7,394,141 (337)

ELF3 promotes hyperglycemia-induced corneal epithelial senescence and IL-2 attenuates ELF3-associated signaling. [PDF]

Front Mol Biosci
Zhou S, Zhang H.
europepmc   +1 more source

Renal Tubular Epithelial Cells Senescence Induced by 1‐Aminopyrene Activates Fibroblast via BRD4 Driven Senescence‐Associated Secretory Phenotype Signaling

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
1‐AP induced genomic instability and senescence in RTECs sustaining BRD4‐dependent SAPS transcription and paracrine fibroblast activation. Targeting BRD4 may treat pollution‐related CKD. ABSTRACT Epidemiological evidence links environmental pollution to chronic kidney disease (CKD).
Atul Katarkar, Ankita Bagde, Diwakar Maurya, Bhavana Chahare, Namita Mane, Saravanadevi Sivanesan, K. Krishnamurthi   +6 more
wiley   +1 more source

Matrix Stiffness Induces Endothelial Network Senescence. [PDF]

Adv Sci (Weinh)
Song J, Rindone AN, Guan Y, Amelung CD, Daswani PS, Elisseeff JH, Gerecht S.   +6 more
europepmc   +1 more source

M2 Macrophage‐Derived Small Extracellular Vesicle miR‐106a‐Loaded QCG Hydrogel Targets the RNF128‐LXR Pathway to Reprogram Chondrocyte Cholesterol Metabolism for Osteoarthritis Therapy

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
Schematic illustration of the molecular mechanisms by which the inflammation‐responsive, injectable hydrogel QCG@sEV‐miR‐106a exerts therapeutic effects in OA. ABSTRACT This study addresses osteoarthritis (OA), in which dysregulated chondrocyte cholesterol homeostasis and cellular senescence contribute to cartilage degeneration, by developing an ...
Baozhe Liu, Zhan Wang, Jingyong Zhang, Wei Du, Lifeng Ding, Shang Piao   +5 more
wiley   +1 more source

Senescent Cell‐Derived Extracellular Vesicles in Therapy‐Induced Senescence: Immune Remodelling and Emerging Links to Mitochondrial Stress in Cancer

Journal of Extracellular Biology, Volume 5, Issue 10, October 2026.
ABSTRACT Cancer therapy can induce cellular senescence and remodel the tumour microenvironment through the senescence‐associated secretory phenotype (SASP), including its membrane‐enclosed component, senescent cell‐derived extracellular vesicles (senEVs). This review summarizes senEV biogenesis, cargo‐dependent functions, and immune‐remodelling effects
Yongrui Qian, Zirui Weng, Na Li, Yun Zhou, Hailong Pei   +4 more
wiley   +1 more source

Targeting YAP1-Mediated Tubular Cell Senescence to Attenuate Maladaptive Repair and Fibrotic Transition After Acute Kidney Injury. [PDF]

FASEB J
Zhao Z, An H, Sang Y, Chen S, Zhou J, Zhang T, Li J, Zhou X.   +7 more
europepmc   +1 more source

Needs, Challenges, and Opportunities for Genetic Counselors in Vietnam: A Qualitative Interview Study With Healthcare Leaders and Genetics Professionals

Journal of Genetic Counseling, Volume 35, Issue 5, October 2026.
ABSTRACT In Vietnam, access to genetic testing has expanded rapidly, but the genetic counseling needed to translate genetic testing results into informed healthcare decisions remains limited. Currently, genetic counseling is provided by physicians or PhD‐trained laboratory geneticists in Vietnam; there are no Master's‐level trained genetic counselors ...
Mai Ly Tran Burke, Peter James B. Abad, Basma M'Barek, Angelica Michelle Raney, Janine S. Bruce, Sylvia Bereknyei Merrell, Hetanshi Naik, Kelly E. Ormond   +7 more
wiley   +1 more source

The Mechanistic Study of Melatonin Regulation of p16Ink4a and Oct4 in Anti-Cellular Senescence. [PDF]

J Cell Mol Med
Xu Y, Zhang C, Wang L, Chen X.
europepmc   +1 more source