Results 151 to 160 of about 45,082 (267)

Polystyrene nanoplastics promotes inflammation and aging in young mice through the oral-gut microbiome axis. [PDF]

Front Immunol
Wang Y, Dong C, Xiao Y.
europepmc   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Induced pluripotent stem cell-derived models of malignant nerve sheath tumor progression mimic glial to neuro-mesenchymal transition and uncover therapeutic opportunities. [PDF]

Nat Commun
Uriarte-Arrazola I, Magallón-Lorenz M, Fernández-Rodríguez J, Zhang J, Lee E, Ortega-Bertran S, Creus-Bachiller E, Farrés-Casas J, Wilson KM, McKnight C, Recabo K, Blanco I, Salvador H, Romagosa C, Lázaro C, Mazuelas H, Gel B, Ferrer M, Carrió M, Serra E.   +19 more
europepmc   +1 more source

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

Regulation of Neuronal Senescence by <i>Srebf2</i> and <i>Zmiz1</i> Reveals Mechanisms of Aging-Related Neurodegeneration. [PDF]

Biology (Basel)
Deng Z, Chen J, Li J, Luo X, Luo Q, Ren M, Li X.   +6 more
europepmc   +1 more source

Intrinsic pH chemosensitivity of acutely dissociated medullary serotonergic and retrotrapezoid neurones

The Journal of Physiology, EarlyView.
Abstract figure legend Central respiratory chemoreceptors (CRCs) are critical for maintaining normal systemic levels of pH and PCO2. A CRC must respond to pH via intrinsic mechanisms. Here we quantified intrinsic chemosensitivity of medullary 5‐HT neurones and retrotrapezoid nucleus (RTN) neurones using acute dissociation.
Yuanming Wu, Eduardo Bravo, George Bradley Richerson   +2 more
wiley   +1 more source

Andrographolide attenuates microglial senescence in Alzheimer's disease mice by suppressing the STAT3 signaling. [PDF]

iScience
Song H, Yang M, Wu S, Dai Q, Qin W, Xie W, Chen Y, Jiang X, Zhang X, Deng X, Ouyang C, Zhang Y, Liu X, Zhu Y, Huang G.   +14 more
europepmc   +1 more source

Parents' experiences of diagnosis and specialist care of children's rare birthmarks

British Journal of Health Psychology, Volume 31, Issue 3, September 2026.
Abstract Objectives Congenital melanocytic naevi (CMN) and arteriovenous malformations (AVM) are rare, severe and incurable birthmark conditions associated with lifelong visible difference and complex medical needs. Despite the importance of early health care experiences for parental and child adjustment in general, these remain unexplored in this ...
Morgan B. Zolkwer, Satyamaanasa Polubothu, Veronica A. Kinsler, Amy Slater, Ella Guest   +4 more
wiley   +1 more source

Implementation and impact of primary HPV testing in cervical cancer screening: Historical perspectives and institutional experience at a large academic medical center

Cancer Cytopathology, Volume 134, Issue 8, August 2026.
Abstract Recognition of high‐risk human papillomavirus (HPV) as the etiologic agent in nearly all cervical cancers has fundamentally reshaped screening strategies, driving the development and adoption of highly sensitive molecular HPV assays. Over the past several decades, cervical cancer screening guidelines have shifted from primarily cytology‐based ...
Rebecca A. Yoda, Eric C. Huang
wiley   +1 more source

Tubular Omega-3 Fatty Acid Receptor FFAR4 Deficiency Aggravated Renal Aging and Chronic Kidney Disease. [PDF]

Aging Cell
Yang L, Tang L, Li J, Liu D, Hu C, Guo F, Lin L, Huang R, Fu P, Ma L.   +9 more
europepmc   +1 more source