Results 141 to 150 of about 2,142,199 (296)

Clinical and molecular features of PRCD‐associated retinopathy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To describe the clinical and genetic characteristics of patients with biallelic disease‐causing variants in the PRCD (Progressive Rod‐Cone Degeneration) gene. Methods Multicentre, retrospective cohort study of 19 patients from 13 families across nine reference centres in six countries.
Vasil Kostin, Karolina Kaminska, Marco Cattaneo, Enrico Ambrosini, Carmen Ayuso, Almudena Ávila‐Fernández, Béatrice Bocquet, Luisa Coutinho‐Santos, Benedetto Falsini, Lidia Fernandez‐Caballero Palomeque, Bohdan Kousal, Petra Liskova, Inmaculada Martín‐Mérida, María Juliana Ballesta‐Martínez, Daan Panneman, Susanne Roosing, Isabelle Meunier, José M. Millán, Monika Pankievič, Irene Perea‐Romero, Virginie Peter, Giorgio Placidi, Cristina Santos, Francesca Simonelli, Ana Berta Sousa, Francesco Testa, Marie Vajter, Marianna Weener, Mathieu Quinodoz, Carlo Rivolta, Giacomo Calzetti   +30 more
wiley   +1 more source

Phagocytosis activity is retained by JMML macrophages and increased by CD47 inhibition

British Journal of Haematology, EarlyView.
Summary Juvenile myelomonocytic leukaemia (JMML) is a childhood myeloid malignancy driven by RAS (rat sarcoma viral oncogene homolog) pathway mutations, characterized by myeloid cell accumulation and organ infiltration. We investigated how clonal macrophage polarization, phagocytic function and CD47 (cluster of differentiation 47) expression contribute
Jun Wang, Jovana Rajak, Hui Xiao, Naile Koleci, Anna Lena Stippel, Ke Meng, Niels Anton Wehner, Sheila Bohler, Riccardo Masetti, Charlotte Niemeyer, Bertram Bengsch, Miriam Erlacher   +11 more
wiley   +1 more source

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

Correlation between Methylation and Expression Level of P15 and P16 Genes during Differentiation of Cord Blood Stem Cells into Erythroid Lineage Mediated by Erythropoietin

Novelty in Biomedicine, 2015
Background: Several influential factors such as transcription factors and intracellular signaling components are involved in differentiation of stem cells into a specific lineage. P15 and p16 proteins are among these factors.
Mehdi Azad, Mehdi Goudarzi, Mehdi Sahmani, Ali Dehghanifard, Naser Mobarra, Mousa Vatanmakanian, Mohammad Hosein Moghaddasi, Fatemeh Skandari, Saeid Kaviani   +8 more
doaj  

Evaluation of p16 and Id1 status and endogenous reference genes in human chondrosarcoma by real-time PCR

, 2005
Both the tumour suppressor, p16, and the helix-loop-helix transcription factor, Id1, have been assigned roles in tumour growth in general and appear to be involved in chondrosarcoma. Id1 has further been found to repress the expression of p16. Therefore,
Asp, Julia,, Brantsing, Camilla, Gamberi, Gabriella, Lövstedt, Karina, Lindahl, Anders,, Picci, Piero, Benassi, Maria Serena, Inerot, Sven,   +7 more
core  

Purpurin Alleviates Meniscal Senescence and Osteoarthritis by Blocking the Non‐Metabolic Function of Hexokinase 2

Cell Proliferation, EarlyView.
HK2 is upregulated in osteoarthritis and accelerates disease progression via a glycolysis‐independent non‐metabolic mechanism. It recruits PRKN to degrade MYH10, reducing COL1A1 mRNA stability and inducing senescence. Purpurin disrupts this pathogenic pathway with therapeutic potential.
Zhencan Lin, Ming Li, Wei Li, Tianfa Xu, Zongrui Jiang, Yanlin Zhong, Aishan He, Xiaoyi Zhao, Dianbo Long, Yan Kang   +9 more
wiley   +1 more source

High frequency of p 16 promoter methylation in non-small cell lung carcinomas from Chile

Biological Research, 2007
The inactivation of tumour suppressor genes by aberrant methylation of promoter regions has been described as a frequent event in neoplasia development, including lung cancer.
LEDA M GUZMAN, CHIHAYA KORIYAMA, SUMINORI AKIBA, YOSHITO EIZURU, DARWINS CASTILLO, ALEJANDRO CORVALAN, FRANCISCO R AGUAYO   +6 more
doaj  

Phylogenetic analysis and expression patterns of p16 and p19 in Paracentrotus lividus embryos

, 2012
P16 and P19 are two small acidic proteins in- volved in the formation of the biomineralized skeleton of sea urchin embryos and adults. Here, we describe the cloning and the embryonic temporal and spatial expression profiles of p16 and p19 mRNAs ...
Caterina Costa, Konstantinos Karakostis, Karakostis, Konstantinos, Zito, Francesca, Costa, Caterina, Francesca Zito, Valeria Matranga, Matranga, Valeria   +7 more
core   +1 more source

Diagnostic Utility of p16 and MTAP Immunohistochemistry for Cellular Neurothekeomas

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Aims Cellular neurothekeoma (cNTK) is a benign cutaneous tumor of uncertain histogenesis. Recent genomic characterization identified recurrent deletions on chromosome 9p21.3, encompassing CDKN2A (p16), as a primary driver event in cNTK. We assessed the potential utility of p16 and MTAP immunohistochemistry for discriminating cNTKs from ...
Joseph S. Durgin, Katharina Wiedemeyer, Grace Wang, Scott C. Bresler, Steven M. Hrycaj, Louise van der Weyden, David J. Adams, Thomas Brenn, Paul W. Harms   +8 more
wiley   +1 more source

Integrated histopathological and molecular diagnostics reveal substantial diagnostic shifts in pediatric melanocytic tumors

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Pediatric melanocytic tumors are rare and biologically heterogeneous. Distinguishing melanomas from Spitz‐lineage tumors based on histomorphology alone is challenging and may lead to inadequate treatment. We aimed to characterize melanocytic tumors in pediatric patients enrolled in the German STEP registry and to ...
Michael Abele, Matthias Hahn, Gisela Metzler, Ulla Graeßner, Maja Haar, Thomas K. Eigentler, Andrea Forschner, Nadja Ballin, Christopher Schroeder, Dominik T. Schneider, Ines B. Brecht, Stephan Forchhammer   +11 more
wiley   +1 more source