Results 111 to 120 of about 1,727,390 (297)
European Journal of Medical ResearchArtesunate (ART), an effective antimalarial semisynthetic derivative of artemisinin, exhibits antitumour properties, but the mechanism(s) involved remain elusive.
Linlin Mao +5 more
doaj +1 more source
p16 Overexpression and Human Papillomavirus Positivity in More Than 1000 Penile Cancers
International Journal of Cancer, EarlyView.ABSTRACT Penile cancer is a severe disease, and a large proportion is related to high‐risk (hr) human papillomavirus (HPV). P16 is used as an immunohistochemical marker of HPV in clinical diagnostics. Population‐based data on the prevalence of p16 in penile cancer is scarce.
Marianne Gardar Stærk +12 more
wiley +1 more source
Expression of p16 protein in breast cancer
Breast cancer is the most common cancer and a leading cause of death in women in Saudi Arabia. P16 is a tumour suppressor gene that plays a crucial role in regulating cell cycle.
Saad Samargandy +3 more
core +1 more source
The Korean Journal of Gastroenterology, 2016 Background : /Aims: Helicobacter pylori infection induces aberrant DNA methylation in gastric mucosa. We evaluated the long-term effect of H. pylori eradication on promotor CpG island hypermethylation in gastric carcinogenesis. Methods : : H.
Jeongmin Choi +5 more
doaj +1 more source
Methylation and mutation analysis of p16 gene in gastric cancer
World Journal of Gastroenterology, 2003 To study methylation, frequencies of homozygous deletion and mutation of p16 gene in gastric carcinoma.The methylation pattern in exon 1 and exon 2 of p16 gene was studied with polymerase chain reaction (PCR), using methylation sensitive restriction endonuclease HpaII and methylation insensitive restriction endonuclease MspI.
Yi, Ding +3 more
openaire +2 more sources
iMeta, EarlyView.The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li +29 more
wiley +1 more source
Inactivation patterns of p16/INK4A in oral squamous cell carcinomas. [PDF]
, 2004 The p16/INK4A is one of the major target genes in carcinogenesis and its inactivation has frequently been reported in other types of tumors. The purpose of this study is to evaluate inactivation patterns of p16/INK4A in oral squamous cell carcinoma.
Kim, MJ +7 more
core +1 more source
Methylation of p16 gene in hematological malignancies.
Chinese medical journal, 2001 To investigate the incidence of p16 gene methylation in hematological malignancies, and the relations between p16 gene methylation and the prognosis of hematological malignancies.Fifty-five patients were studied by restriction enzyme polymerase chain reaction (PCR) to detect p16 gene methylation.p16 gene methylation was detected in 6 of 55 patients (10.
W, Chen, J, Zhu, J, Liu, S, Tan
openaire +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Monocrotaline (MCT), a plant‐derived pyrrolizidine alkaloid, is well known for its hepatotoxic effects. However, full elucidation of the mechanisms underlying MCT‐induced hepatotoxicity, as well as the development of reliable biomarkers for early detection and monitoring, requires an integrated evaluation of biochemical, molecular, and ...
Ali Şenol +4 more
wiley +1 more source
Cloning and characterization of murine p16(INK4a) and p15(INK4b) genes
, 1995 Progression through the G1 phase of the cell cycle is regulated in part by the D-type cyclin-dependent kinases, cdk4 and cdk6. Genes encoding two specific inhibitors of these kinases, human p16((INK4a/MTS1)) and p15((INK4b/MTS2)) map to a region of ...
Quelle, D. E. +9 more
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