Results 31 to 40 of about 1,681,356 (252)

Relation of the methylation state of RUNX3 and p16 gene promoters with hepatocellular carcinoma in Egyptian patients

Egyptian Journal of Medical Human Genetics, 2022
Background Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy of adults. RUNX3 and p16 are tumor suppressor genes that may be inactivated by hypermethylation which is a key epigenetic mechanism that contributes to the initiation
Fatma El-shaarawy, Mai M. Abo ElAzm, Rasha H. Mohamed, Mohamed I. Radwan, Dina M. Abo-Elmatty, Eman T. Mehanna   +5 more
doaj   +1 more source

DNA Methylation Profiling Revealed Promoter Hypermethylation-induced Silencing of p16, DDAH2 and DUSP1 in Primary Oral Squamous Cell Carcinoma [PDF]

, 2014
Background: Hypermethylation in promoter regions of genes might lead to altered gene functions and result in malignant cellular transformation. Thus, biomarker identification for hypermethylated genes would be very useful for early diagnosis, prognosis ...
Zain, R. B., Vincent-Chong, V. K., Tan, A. C., Khor, G. H., Thong, K. L., Omar, E., Froemming, G. R. A., Abraham, M. T., Tan, S. K.   +8 more
core   +1 more source

Prediction of progression in pTa and pT1 bladder carcinomas with p53, p16 and pRb. [PDF]

, 2004
Currently available prognostic tools appear unable to adequately predict recurrence and progression in non muscle-invasive bladder carcinomas. We aimed to assess the prognostic value of immunohistochemical evaluation of the cell cycle markers p53, p16 ...
S Jordan, Martin, J, J Martin, Hitchings, AW, M Kumar, Jordan, S, D M Berney, Nargund, V, Kumar, M, Berney, DM, A W Hitchings, V Nargund   +11 more
core   +1 more source

Activating senescence in p16-positive Basal-like breast cancer. [PDF]

, 2016
PhDBreast cancer is the most common cancer in the UK and Basal-like breast cancer (a highly aggressive subtype) accounts for approximately 8-22% of all cases depending on ethnicity.
Moore, Madeleine
core   +4 more sources

Epigenetic regulation of multiple tumor-related genes leads to suppression of breast tumorigenesis by dietary genistein. [PDF]

PLoS ONE, 2013
Breast cancer is one of the most lethal diseases in women; however, the precise etiological factors are still not clear. Genistein (GE), a natural isoflavone found in soybean products, is believed to be a potent chemopreventive agent for breast cancer ...
Yuanyuan Li, Huaping Chen, Tabitha M Hardy, Trygve O Tollefsbol   +3 more
doaj   +1 more source

Epigenetic and genomic biomarker discovery in breast cancer [PDF]

, 2011
Breast cancer is the most common malignancy among females and the fifth most common cause of cancer death worldwide. The research for biomarker discovery for the diagnosis and prognosis of patients with breast cancer has been going on for decades ...
Radpour, Ramin
core   +1 more source

Genome-wide overexpression screen identifies genes able to bypass p16-mediated senescence in melanoma [PDF]

, 2017
Malignant melanomas often arise from nevi, which result from initial oncogene-induced hyperproliferation of melanocytes that are maintained in a CDKN2A/p16-mediated senescent state.
Stevenson, Alexander J, Gonda, Thomas J., Gabrielli, Brian, Fox, Carly, Yaswen, Paul, Gonda, Thomas J, Stevenson, Alexander J., Skalamera, Dubravka, Ranall, Max V, Shakhbazov, Konstanin, Lambie, Duncan, Lee, Won Jae, Dahmer-Heath, Mareike, Ranall, Max V.   +13 more
core   +1 more source

FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma. [PDF]

, 2012
PMCID: PMC3312909This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited ...
Ahmad Waseem (155362), Emilios Gemenetzidis (176601), Adiam W. Bahta (176614), Nadir, A, Ayesha Nadir, Ahmad Waseem, Deeviyaben Patel (176603), Gemenetzidis Emilios, Iain L. Hutchison (155346), Bahta, AW, Ayesha Nadir (176609), Hutchison, IL, Nadir Ayesha, Teh, MT, Iain L Hutchison, Muy-Teck Teh, Teh, M-T, Rameez Tariq, Gemenetzidis, E, Adiam W Bahta, Teh Muy-Teck, Muy-Teck Teh (155335), Patel, D, Emilios Gemenetzidis, Patel Deeviyaben, Waseem Ahmad, Tariq, R, Waseem, A, Deeviyaben Patel, Rameez Tariq (176604), Tariq Rameez, Hutchison Iain L., Bahta Adiam W.   +32 more
core   +2 more sources

Loss of Heterozygosities in Five Tumor Suppressor Genes (FHIT Gene, p16, pRb, E-Cadherin and p53) in Thyroid Tumors [PDF]

Clinical and Experimental Otorhinolaryngology, 2014
ObjectivesTo evaluate the loss of heterozygosities (LOH) of chromosomes 3p14 (FHIT gene), 9p21 (p16), 13q21 (pRb), 6q22 (E-cadherin) and 17p13 (p53) in various thyroid tumors.MethodsEighty thyroid tumor cases (20 follicular adenomas, 10 follicular ...
Jin Hwan Kim, Kyu Young Choi, Dong Jin Lee, Young-Soo Rho, Sung-Jin Jo   +4 more
doaj   +1 more source

Increased Radiosensitivity of p16 Gene‐deleted Human Glioma Cells after Transfection with Wild‐type p16 Gene [PDF]

Japanese Journal of Cancer Research, 1997
The A1235 and T98 cell lines derived from human gliomas have homozygous deletions in their p16 genes and are radiosensitive and radioresistant, respectively, with respect to other established glioma cell lines. These differences in radiosensitivity may be due to variations to some extent among cell lines, rather than genetically defined resistance or ...
Miyakoshi, Junji, Kitagawa, Kaori, Yamagishi, Nobuyuki, Ohtsu, Shuji, Day, Rufus S., Takebe, Hiraku   +5 more
openaire   +2 more sources