Results 91 to 100 of about 2,142,199 (296)

Yoda1‐Functionalized Nanozymes Coordinate Piezo1 Activation and Mitochondrial Protection to Reprogram the Diabetic Osteoimmune Micromilieu and Promote Vascularized Bone Repair

Advanced Science, EarlyView.
Diabetic bone defects remain a critical clinical challenge. A 3D‐printed BCPG‐MF@Y scaffold, embedding Yoda1‐functionalized manganese dioxide‐ferritin nanozymes, scavenges mtROS, suppresses the cGAS–STING pathway, and reverses cellular senescence, while Yoda1 activates Piezo1 to direct BMSCs fate to synergistically reprogram the osteoimmune ...
Qing‐Song Deng, Ang Wang, Ren Zhang, Xu‐Ran Li, Po‐Lin Liu, Shu‐Hang He, Zi‐Yin Han, Zhi‐Han Shen, Zhan‐Ying Wei, Chang‐Ru Zhang, Fei Wang, Helen Dawes, Jian Lu, Tong‐He Zhu, Jin‐Zhong Zhao, Shang‐Chun Guo, Shi‐Cong Tao   +16 more
wiley   +1 more source

Role of key-regulator genes in melanoma susceptibility and pathogenesis among patients from South Italy

BMC Cancer, 2009
Background Several genetic alterations have been demonstrated to contribute to the development and progression of melanoma. In this study, we further investigated the impact of key-regulator genes in susceptibility and pathogenesis of such a disease ...
Canzanella Sergio, Stanganelli Ignazio, Pagani Elena, Ascierto Paolo A, Caracò Corrado, Budroni Mario, Cossu Antonio, Muggiano Antonio, Casula Milena, Sini MariaCristina, Palomba Grazia, Palmieri Giuseppe   +11 more
doaj   +1 more source

KRAS, BRAF oncogene mutations and tissue specific promoter hypermethylation of tumor suppressor SFRP2, DAPK1, MGMT, HIC1 and p16 genes in colorectal cancer patients [PDF]

, 2016
BACKGROUND: Colorectal cancer is a serious disease that causes significant morbidity and mortality in developed countries. Genetic changes, such as mutations in proto-oncogenes and DNA repair genes, and loss of function in the tumor suppressor genes ...
Sari, Musa, Bagci, Gokhan, Turan, Mustafa, Karadayi, Kursat, Ozdemir, Ozturk, Bagci, Binnur   +5 more
core   +1 more source

Disabling COMPASS Promoter Licensing Shifts HDAC‐Inhibited Gastric Cancer Toward Sustained Transcriptional Suppression During Recovery

Advanced Science, EarlyView.
Combined inhibition of the WDR5 WIN pocket and HDAC activity converts SAHA‐induced hyperacetylation into a promoter state with reduced WDR5–COMPASS association and H3K4me3. MYC/E2F‐linked nascent transcription and biosynthetic recovery are suppressed, while apoptosis and senescence‐like features increase, resulting in sustained growth inhibition in ...
Jintian Song, Hui Yu, Jianping Jiang, Zhihui Jiang, Zhongshi Hong, Xu Zhang, Luchuan Chen, Shenghong Wei, Yi Wang   +8 more
wiley   +1 more source

Assessing the Diagnostic Accuracy of Salivary Biomarkers in Detecting Oral Squamous Cell Carcinoma

Journal of Pharmacy and Bioallied Sciences
Background: Attempts should be made to identify the molecule-based biomarkers, which give indication about the progression of precancer and malignancy of the oral area.
Priyanka Vinod Bansal, Liza Mohanty, Chinmay Raval, Inderjit M. Gowdar, Anshul Chopra, Bharti Gupta, Ramanpal S. Makkad   +6 more
doaj   +1 more source

Relationship between inactivation of p16 gene and gastric carcinoma

World Journal of Gastroenterology, 2003
To investigate the relationship between inactivation of p16 gene and gastric carcinoma, and the mechanism of inactivation of p16 gene in gastric carcinogenesis.40 fresh tumor tissue specimens were taken from primary gastric cancer patients. Expression of P16 protein was detected by immunohistochemical method.
Guo-Hai, Zhao, Tie-Chen, Li, Liang-Hui, Shi, Ya-Bin, Xia, Lin-Ming, Lu, Wen-Bin, Huang, Hui-Lan, Sun, Yi-Sheng, Zhang   +7 more
openaire   +2 more sources

Alterations of p16(INK4A) and p15(INK4B) genes in gastric carcinomas

, 1997
BACKGROUND. It has been suggested that cyclin-dependent kinase inhibitors (CDKIs), including p16 and p15, are tumor suppressor genes. Alterations of CDKIs have been found in most types of cancer.
Seo, Jin Y., Kim, Noe K., Jung, Chul W., Choe, Kuk J., Koeffler, H. Phillip, Kim, Byoung K., Lee, Young Y., Lee, Kuhn U., Kang, Shin H., Bang, Yung‐Jue   +9 more
core   +1 more source

Long‐Term Expandable Periosteal Organoids Reconstruct a Functional Regenerative Niche That Support Hematopoietic Stem Cell Maintenance and Bone Repair

Advanced Science, EarlyView.
A robust periosteal organoid system enables long‐term expansion while preserving native cellular heterogeneity. These organoids recapitulate functional niche environments, support hematopoietic stem cell maintenance, and attenuate aging‐associated decline ex vivo.
Jia Qing, Lanxin Gu, Lipeng Fu, Xin Gao, Zechuan Li, Hui Zhang, Wenpeng Song, Huixin Lv, Yongsheng Zhou, Ping Zhang   +9 more
wiley   +1 more source

Promoter hypermethylation of multiple genes in hydatidiform mole and choriocarcinoma

, 2004
The methylation status of genes in hydatidiform mole and choriocarcinoma and its significance is relatively unexplored. We investigated the methylation status of the promoter regions of six genes, p16, HIC-1, TIMP3, GSTP1, death-associated protein kinase
Hextan Y.S. Ngan, Tsao, SW, Xue, WC, Chan, KYK, Ngan, HYS, Chiu, PM, Kelvin Y.K. Chan, Hui-Chen Feng, Cheung, ANY, Sai-Wah Tsao, Annie N.Y. Cheung, Wei-Cheng Xue, Feng, HC, Pui-Man Chiu   +13 more
core   +1 more source

Simultaneous Inactivation of the p16, p15, and p14 Genes Encoding Cyclin-Dependent Kinase Inhibitors in Canine T-lymphoid tumor cells [PDF]

The p16, p15, and p14 genes are widely known as tumor suppressor genes in human medicine. Although a large number of genetic and epigenetic aberrations in these genes have been reported in human malignancies, canine malignancies have not been well ...
244, 40709755, 藤原, 亜紀
core   +1 more source