Results 131 to 140 of about 47,513 (307)

Microbial keystone taxa and metabolic signatures in centenarians regulate intestinal homeostasis during aging

iMeta, EarlyView.
Clostridium scindens and its metabolite indole‐3‐acetic acid (IAA) are identified as a keystone taxon and metabolic signature in centenarians. Clostridium scindens enhances microbial network stability and produces IAA via its own amidase (AMIE) and aldehyde dehydrogenase (ALDH), thus promoting intestinal homeostasis by activating the aryl hydrocarbon ...
Wei‐Chuan Lin, Cui Zhang, He‐Hua Lei, Zheng Cao, Xin Gao, Wen‐Kai Yu, Xin‐Zhi Li, Qing‐Wei Xiang, Zhi‐Wen Zhang, Shi‐Fu Pang, Wei‐Fei Luo, Deng‐Hui Xie, Li‐Min Zhang, Gang Chen   +13 more
wiley   +1 more source

Promoter Hypermethylation in Tumor Suppressing Genes p16 and FHIT and Their Relations Estrogen Receptor Status in Breast Cancer Patients from Northern India

, 2009
BACKGROUND: Aberrant DNA methylation has been recognized in human breast carcinogenesis as a common molecular alteration associated with the loss of expression of a number of key regulatory genes.
Gupta, Pawan, Raish, Mohammad, Ansari, Mushtaq Ahmad, Shukla, N.K., Das, Bhudev Chandra, Husain, Syed Akhtar, Ahmad, Arif, Batra, Vineeta, Mudassar, Shahid, Shahid, Mohammad, Dhillon, Varinderpal S.   +10 more
core   +1 more source

Biochemical and Molecular Insights Into Monocrotaline‐Induced Hepatotoxicity: An Experimental Mouse Study

Journal of Applied Toxicology, EarlyView.
ABSTRACT Monocrotaline (MCT), a plant‐derived pyrrolizidine alkaloid, is well known for its hepatotoxic effects. However, full elucidation of the mechanisms underlying MCT‐induced hepatotoxicity, as well as the development of reliable biomarkers for early detection and monitoring, requires an integrated evaluation of biochemical, molecular, and ...
Ali Şenol, Alparslan Kadir Devrim, Miyase Çinar, Mahmut Sözmen, Fatma Betül Akça   +4 more
wiley   +1 more source

Investigation of Genetic Markers for Predicting Oral Cancer Progression and Patient Outcomes

Journal of Pharmacy and Bioallied Sciences
Background: Genomic methylation being used as a sensitive indicator for identifying oral potentially malignant disorders (OPMDS) and oral cancer could be a viable option.
Amit Wasti, Liza Mohanty, Ruchira Shukla, Bharti Gupta, Inderjit Murugendrappa Gowdar, Tarang Mehta, Ramanpal Singh Makkad   +6 more
doaj   +1 more source

Experiencing 50 Years of Synergistic Development in Structural Biology and Enzymology

Journal of the Chinese Chemical Society, EarlyView.
Picture of Sunney Chan with Academia Sinica (AS) President James C. Liao and three Vice Presidents: Shin‐Kun Peng (left one), Tang K. Tang (right one), and Mei‐Yin Chou (right 2), taken at the annual Chinese New Year's Banquet of AS, February 7, 2025. This was likely Sunney's last appearance in formal activities of AS.
Ming‐Daw Tsai
wiley   +1 more source

CDKN2a (cyclin dependent kinase 2a / p16)

, 2004
Review on CDKN2a (cyclin dependent kinase 2a / p16), with data on DNA, on the protein encoded, and where the gene is ...
Lemoine, A, Debuire, B, Saffroy, R
core   +1 more source

Dasatinib and quercetin prevent alveolar bone loss in aged mice

Journal of Periodontology, EarlyView.
Abstract Background Recent findings have associated alveolar bone loss (ABL) with the presence of senescent cells. Aging and the accumulation of senescent cells are associated with a pro‐inflammatory environment which may exacerbate tissue damage.
Luisa S. Battistelli, Renata M. Moraes, Yuri C. Santos, Jaqueline L. Ribeiro, Maíra T. Garcia, Renata F. Prado, Florent Elefteriou, Ana Lia Anbinder   +7 more
wiley   +1 more source

Aging and periodontitis increase brain dissemination of oral bacteria

Journal of Periodontology, EarlyView.
Abstract Background The microbiome is a dynamic system that changes throughout life. Studies have revealed the relationship between periodontal disease and the oral microbiota; however, the impact of periodontal disease on the expression of senescence markers and on the inflammaging of the oral and systemic microbiome remains unclear.
Ozge Unlu, Tsute Chen, Nil Yakar, Zeliha Guney, Bruce Paster, Isabel Carreras, Alpaslan Dedeoglu, Alpdogan Kantarci   +7 more
wiley   +1 more source

Epigenetic Modifications of DAPK and p16 Genes Contribute to Arsenic-Induced Skin Lesions and Nondermatological Health Effects

, 2013
Over 26 million people in West Bengal, India, are exposed to very high levels of arsenic through drinking water, leading to several deleterious endpoints including cancers.
Ashok K. Giri, Giri, Ashok K, Jayanta K. Das, Somnath Paul, Banerjee, Saptarshi, Tanmoy J. Sau, Banerjee, Nilanjana, Paul, Somnath, Das, Jayanta K, Saptarshi Banerjee, Nilanjana Banerjee, Bandyopadhyay, Apurba, Apurba Bandyopadhyay, Sau, Tanmoy J   +13 more
core   +1 more source

Refining the Multivariable Predictive‐Prognostic PREDICTR‐OPC Model for Survival in Surgical Escalation for Oropharyngeal Squamous Cell Carcinoma

The Laryngoscope, EarlyView.
The PREDICTR‐OPC model is the only prognostic classifier for oropharyngeal squamous cell carcinoma (OPSCC) that also predicts surgical outcomes. This study demonstrates that removing survivin from the model preserves its prognostic and predictive performance, with comparable discrimination, calibration, and clinical utility across training and ...
Lauren L. Zhang, Caroline Kristunas, C. Max Robinson, Jill M. Brooks, Alice J. Sitch, Stuart C. Winter, Justin Weir, Paul Matthews, Terry M. Jones, Keith Hunter, Pawel Golusinski, Ketan A. Shah, Selvam Thavaraj, Catharine M. West, Syed Haider, Edward Odell, Paul Nankivell, Sandra V. von Zeidler, Hisham Mehanna   +18 more
wiley   +1 more source