Results 31 to 40 of about 46,467 (169)

Polycomb CBX7 directly controls trimethylation of histone H3 at lysine 9 at the p16 locus. [PDF]

PLoS ONE, 2010
H3K9 trimethylation (H3K9me3) and binding of PcG repressor complex-1 (PRC1) may play crucial roles in the epigenetic silencing of the p16 gene. However, the mechanism of the initiation of this trimethylation is unknown.In the present study, we found that
Qiang Li, Xiuhong Wang, Zheming Lu, Baozhen Zhang, Zhenpo Guan, Zhaojun Liu, Qiming Zhong, Liankun Gu, Jing Zhou, Budong Zhu, Jiafu Ji, Dajun Deng   +11 more
doaj   +1 more source

Induction of p16(INK4a) is the major barrier to proliferation when Epstein-Barr virus (EBV) transforms primary B cells into lymphoblastoid cell lines. [PDF]

PLoS Pathogens, 2013
To explore the role of p16(INK4a) as an intrinsic barrier to B cell transformation by EBV, we transformed primary B cells from an individual homozygous for a deletion in the CDKN2A locus encoding p16(INK4a) and p14(ARF). Using recombinant EBV-BAC viruses
Lenka Skalska, Robert E White, Gillian A Parker, Ernest Turro, Alison J Sinclair, Kostas Paschos, Martin J Allday   +6 more
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P16INK4A—More Than a Senescence Marker

Life, 2022
Aging is a biological feature that is characterized by gradual degeneration of function in cells, tissues, organs, or an intact organism due to the accumulation of environmental factors and stresses with time.
Hasan Safwan-Zaiter, Nicole Wagner, Kay-Dietrich Wagner   +2 more
doaj   +1 more source

Estudo genético do gene p16 pela técnica de PCR-SSCP e expressão de proteína p16 em melanomas de mucosa oral e melanomas cutâneos Genetic analysis of p16 gene by PCR-SSCP technique and protein p16 expression in oral mucosa and skin melanomas

Anais Brasileiros de Dermatologia, 2006
FUNDAMENTOS: A deleção e mutação do gene CDKN2a que codifica um inibidor específico da ciclina dependente de quinase 4, a proteína p16, têm sido implicadas na tumorigênese do melanoma cutâneo. Entretanto, pouco se conhece sobre essas alterações genéticas
Ricardo Hsieh, Fabrício Bitu Sousa, Aline Firmiano, Fabio Daumas Nunes, Marina Helena Cury Gallottini de Magalhães, Mírian Nacagami Sotto   +5 more
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Expression of p16 Within Myenteric Neurons of the Aged Colon: A Potential Marker of Declining Function

Frontiers in Neuroscience, 2021
Human colonic neuromuscular functions decline among the elderly. The aim was to explore the involvement of senescence. A preliminary PCR study looked for age-dependent differences in expression of CDKN1A (encoding the senescence-related p21 protein) and ...
Alexandra Palmer, Sarah Epton, Ellie Crawley, Marilisa Straface, Luke Gammon, Meghan M. Edgar, Yichen Xu, Shezan Elahi, Joanne Chin-Aleong, Joanne E. Martin, Joanne E. Martin, Cleo L. Bishop, Cleo L. Bishop, Charles H. Knowles, Charles H. Knowles, Gareth J. Sanger   +15 more
doaj   +1 more source

p16 gene homozygous deletions in acute lymphoblastic leukemia [PDF]

Blood, 1995
The p16 protein is a cyclin inhibitor encoded by a gene located in 9p21, which may have antioncogenic properties, and is inactivated by homozygous p16 gene deletion or, less often, point mutation in several types of solid tumors often associated to cytogenetic evidence of 9p21 deletion.
B, Quesnel, C, Preudhomme, N, Philippe, M, Vanrumbeke, I, Dervite, J L, Lai, F, Bauters, E, Wattel, P, Fenaux   +8 more
openaire   +2 more sources

Detection of somatic copy number deletion of the CDKN2A gene by quantitative multiplex PCR for clinical practice

Frontiers in Oncology, 2022
BackgroundA feasible method to detect somatic copy number deletion (SCND) of genes is still absent to date.MethodsInterstitial base-resolution deletion/fusion coordinates for CDKN2A were extracted from published articles and our whole genome sequencing ...
Yuan Tian, Jing Zhou, Juanli Qiao, Zhaojun Liu, Liankun Gu, Baozhen Zhang, Youyong Lu, Rui Xing, Dajun Deng   +8 more
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The Role of p16, p21, p27, p53 and Ki-67 Expression in the Differential Diagnosis of Cutaneous Squamous Cell Carcinomas and Keratoacanthomas: An Immunohistochemical Study

Balkan Medical Journal, 2016
Background: Distinguishing squamous cell carcinoma (SCC) from keratoacanthoma (KA) by histopathological features may not be sufficient for a differential diagnosis, as KAs may, in some cases, imitate well-differentiated SCCs.
Recep Bedir, Hasan Güçer, İbrahim Şehitoğlu, Cüneyt Yurdakul, Pelin Bağcı, Pelin Üstüner   +5 more
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Frequent Hypermethylation of p16 and p15 Genes in Multiple Myeloma [PDF]

Blood, 1997
Abstract Both p16 and p15, encoded by the genes located on chromosome 9p21, are inhibitors of cyclin-dependent kinases (CDK4/6) and the upstream regulators of Rb function. In hematopoietic malignancies, deletion of p16/p15 locus has been shown to be highly specific to lymphoid, and more particularly from B-lineage malignancies except ...
M H, Ng, Y F, Chung, K W, Lo, N W, Wickham, J C, Lee, D P, Huang   +5 more
openaire   +2 more sources

Co-transfection of p16(INK4a) and p53 genes into the K562 cell line inhibits cell proliferation

Haematologica, 2002
BACKGROUND AND OBJECTIVES: The tumor suppressor genes p53 and p16(INK4a), both of which act in tumor surveillance, are homozygously deleted in the human leukemia cell line K562. This study was performed to assess whether co-transfection of the p16(INK4a)
HB Rui, JZ Su
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