Results 61 to 70 of about 46,467 (169)

Methylation and mutation analysis of p16 gene in gastric cancer

World Journal of Gastroenterology, 2003
To study methylation, frequencies of homozygous deletion and mutation of p16 gene in gastric carcinoma.The methylation pattern in exon 1 and exon 2 of p16 gene was studied with polymerase chain reaction (PCR), using methylation sensitive restriction endonuclease HpaII and methylation insensitive restriction endonuclease MspI.
Yi, Ding, Xiao-Ping, Le, Qin-Xian, Zhang, Peng, Du   +3 more
openaire   +2 more sources

Methylation of p16 gene in hematological malignancies.

Chinese medical journal, 2001
To investigate the incidence of p16 gene methylation in hematological malignancies, and the relations between p16 gene methylation and the prognosis of hematological malignancies.Fifty-five patients were studied by restriction enzyme polymerase chain reaction (PCR) to detect p16 gene methylation.p16 gene methylation was detected in 6 of 55 patients (10.
W, Chen, J, Zhu, J, Liu, S, Tan
openaire   +1 more source

The role of p16 gene in oesophageal carcinoma

, 2012
published_or_final_version ; Medical Sciences ; Master ; Master of Medical ...
openaire   +2 more sources

P16-positive senescent cells promote DKD by the dysregulation of glycolysis and mitochondrial metabolism

Cell Death Discovery
Diabetic kidney disease (DKD) is characterized by kidney damage and abnormal renal energy metabolism, but the molecular mechanism of DKD is still unclear.
Xiao Lu, Jiao Wu, Ewud Agborbesong, Xiaogang Li   +3 more
doaj   +1 more source

Investigation of Genetic Markers for Predicting Oral Cancer Progression and Patient Outcomes

Journal of Pharmacy and Bioallied Sciences
Background: Genomic methylation being used as a sensitive indicator for identifying oral potentially malignant disorders (OPMDS) and oral cancer could be a viable option.
Amit Wasti, Liza Mohanty, Ruchira Shukla, Bharti Gupta, Inderjit Murugendrappa Gowdar, Tarang Mehta, Ramanpal Singh Makkad   +6 more
doaj   +1 more source

Correlation between Methylation and Expression Level of P15 and P16 Genes during Differentiation of Cord Blood Stem Cells into Erythroid Lineage Mediated by Erythropoietin

Novelty in Biomedicine, 2015
Background: Several influential factors such as transcription factors and intracellular signaling components are involved in differentiation of stem cells into a specific lineage. P15 and p16 proteins are among these factors.
Mehdi Azad, Mehdi Goudarzi, Mehdi Sahmani, Ali Dehghanifard, Naser Mobarra, Mousa Vatanmakanian, Mohammad Hosein Moghaddasi, Fatemeh Skandari, Saeid Kaviani   +8 more
doaj  

High frequency of p 16 promoter methylation in non-small cell lung carcinomas from Chile

Biological Research, 2007
The inactivation of tumour suppressor genes by aberrant methylation of promoter regions has been described as a frequent event in neoplasia development, including lung cancer.
LEDA M GUZMAN, CHIHAYA KORIYAMA, SUMINORI AKIBA, YOSHITO EIZURU, DARWINS CASTILLO, ALEJANDRO CORVALAN, FRANCISCO R AGUAYO   +6 more
doaj  

Prognostic prediction of the immunohistochemical expression of p16 and p53 in cutaneous melanoma: a comparison of two populations from different geographical regions

European Journal of Histochemistry, 2009
p16INK4a and p53 are tumor-suppressor genes frequently altered in various malignancies, including cutaneous melanoma. The purpose of the study was to establish the prognostic value of immunohistochemical expression of p16INK4a and p53 in sporadic ...
P Sirigu, F Piras, L Minerba, D Murtas, C Maxia, R Colombari, A Corbu, MT Perra, J Ugalde   +8 more
doaj  

Gene therapy for p16-overexpressing cells

Aging, 2018
openaire   +2 more sources

Insights Into the Interplay Between the Senescent Cells and Immune Cells. [PDF]

Aging Cell
Jaros M, Schmidt M, Neubert L, Kamp JC, von Vietinghoff S, Bräsen JH, Schmitt R, Melk A.   +7 more
europepmc   +1 more source