Results 221 to 230 of about 255,591 (268)

The p53 network: p53 and its downstream genes

Colloids and Surfaces B: Biointerfaces, 2007
The tumor-suppressor gene p53 and its downstream genes consist of a complicated gene network. p53 is a key molecular node in the network, which is activated in response to several cellular signals resulting in the maintenance of genetic stability. Several cellular signals may activate the p53 network.
Kun-Xian, Shu, Biao, Li, Li-Xiang, Wu
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The p53 tumour suppressor gene

Nature, 1991
The cell cycle is composed of a series of steps which can be negatively or positively regulated by various factors. Chief among the negative regulators is the p53 protein. Alteration or inactivation of p53 by mutation, or by its interactions with oncogene products of DNA tumour viruses, can lead to cancer.
A J, Levine, J, Momand, C A, Finlay
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CLINICAL IMPLICATIONS OF THE p53 GENE

Annual Review of Medicine, 1996
▪ Abstract  The capacity for malignant growth is acquired by the stepwise accumulation of defects in specific genes regulating cell growth and tissue homeostasis. Although several hundred genes are known to control growth, molecular genetic studies in cancer show that few of these are consistently involved in the natural history of human cancer, and ...
D, Sidransky, M, Hollstein
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Gene-targeting and the p53 tumor-suppressor gene

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1994
Gene-targeting techniques are now frequently applied to embryonic stem (ES) cells to introduce mutations of endogenous genes in mice. Modifications introduced into tumor-suppressor genes by this technology have produced mice and cell lines with unique tumorigenic and growth characteristics, respectively.
A, Sands, L A, Donehower, A, Bradley
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Oncogenic forms of p53 inhibit p53-regulated gene expression

Science, 1992
Mutant forms of the gene encoding the tumor suppressor p53 are found in numerous human malignancies, but the physiologic function of p53 and the effects of mutations on this function are unknown. The p53 protein binds DNA in a sequence-specific manner and thus may regulate gene transcription.
S E, Kern, J A, Pietenpol, S, Thiagalingam, A, Seymour, K W, Kinzler, B, Vogelstein   +5 more
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The functions of the p53 gene and gene product

Journal of Gastroenterology and Hepatology, 1993
Abstractp53 is a tumour suppressor protein involved in the regulation of the cell cycle. Mutation of the p53 gene and expression of mutant p53 protein are associated with many types of human neoplasia. Mutational hot spots at specific amino acid residues have been identified, and these hot spot mutations are differentially expressed in tumours of ...
R. S. QUARTIN, A. J. LEVINE
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Adenovirus p53 gene therapy

Expert Opinion on Biological Therapy, 2005
To date, dysfunctional tumour suppressor genes are the most common genetic lesions identified in human cancers. Functional copies of tumour suppressor genes can be introduced into cancer cells by gene transfer using adenoviral vectors. This approach has been extensively studied in the clinic with intratumoural injection of a replication-defective ...
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p53 Expression and p53 Gene Mutation in Oral Cancer and Dysplasia

Otolaryngology–Head and Neck Surgery, 1998
BACKGROUNDThe aim of the current study was to examine the possible association of the p53 tumor suppressor gene with the development of oral cancer. We examined biopsy material from patients with oral squamous cell carcinoma for p53 protein expression and p53 mutations.METHODSEighteen samples were analyzed.
H, Rowley, P, Sherrington, T R, Helliwell, A, Kinsella, A S, Jones   +4 more
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p53 protein accumulation and p53 gene mutation in colorectal cancer

Pathology & Oncology Research, 2000
Comparison of immunohistochemical methods for detection of protein p53 accumulation and molecular techniques for analysis p53 gene mutation in colorectal cancer is presented. Thirty eight patients were included: all underwent surgery without preoperative treatment.
A, Nasierowska-Guttmejer , L, Trzeciak , M P, Nowacki , J, Ostrowski   +3 more
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p53 gene mutations in gastric adenomas

Virchows Archiv B Cell Pathology Including Molecular Pathology, 1993
p53 gene alterations in ten gastric adenomas and one carcinoma arising in an adenoma were analyzed by deoxynucleotide sequencing. Three (30%) of the ten gastric adenomas had p53 gene mutations, one adenoma showing a frameshift mutation and two others showing silent mutations.
H, Tohdo, H, Yokozaki, K, Haruma, G, Kajiyama, E, Tahara   +4 more
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