Results 231 to 240 of about 2,017,768 (306)

Targeting the HPV E6-p53 degradation axis via computational and <i>in vitro</i> identification of a repurposed small-molecule candidate. [PDF]

Front Oncol
Harishkumar SD, Pasha S, Edwin R, Madashetty S, Shreevatsa B, Kollur SP, Shivamallu C, Dharmashekar C.   +7 more
europepmc   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

Host genetic determinants of HTLV-1 infection outcomes. [PDF]

Immunol Res
Akbarin MM, Farjami Z, Álvarez HR.
europepmc   +1 more source

Thymidylate synthase inhibitory drugs induce p53-dependent pathways differently. [PDF]

PLoS One
Holub E, Szajkó MB, Felföldi A, Vértessy BG, Békési A.   +4 more
europepmc   +1 more source

DDX21 Enhances Radiosensitivity in Head and Neck Squamous Cell Carcinoma by Suppressing MK2‐Mediated DNA Damage Response

Advanced Science, EarlyView.
DDX21 suppresses MK2 activation by directly inhibiting Thr334 phosphorylation in a p38‐independent manner, thereby impairing DNA damage response. Clinically, patients with well‐differentiated tumors exhibiting high DDX21 expression are more likely to benefit from adjuvant radiotherapy, whereas those with low DDX21 levels are predisposed to ...
Tianru Yang, Ting Shen, Yanfang Qiu, Wei Zhang, Ziran Zheng, Jiayi Sun, Yuedi Yao, Mianfeng Yao, Jiang Li   +8 more
wiley   +1 more source

Impact of cigarette toxicants on sarcopenic obesity: An in silico network toxicology and molecular dynamics study. [PDF]

Tob Induc Dis
Li Z, Li D, Huang Y, Liu Y, Ouyang X, Xu Y, Wu W, Zhong Y, Wang M.   +8 more
europepmc   +1 more source

Multi‐Tissue Crosstalk Regulating Meniscus Healing Under Inflammation and Physiological Loading

Advanced Science, EarlyView.
Using a novel Meniscus‐on‐a‐chip (MoC) model integrated with a meniscus‐specific bioreactor, this study investigated the roles of multi‐tissue crosstalk that regulates injury, healing, and degeneration of the meniscus injury under inflammation and pathophysiological loading.
Hun Jin Jeong, Elen Zhu, Min Seo Kang, Ming Wang, Sam Comito, Chang H. Lee   +5 more
wiley   +1 more source

An Isogenic Yeast Model Reveals the Influence of Native Promoter G‑Quadruplex Forming Sequences on P53 and NF-κB Transactivation. [PDF]

ACS Bio Med Chem Au
Kratochvilová L, Orság P, Drápalová K, Stříž R, El Rashed Z, Menichini P, Ohki R, Monti P, Inga A, Brázda V.   +9 more
europepmc   +1 more source

Magneto‐Sono‐Enhanced Nanozyme Catalysis Drives ROS‐Mediated Pathogen Killing and Mitophagy‐Linked Inflammation Control in Bacterial Pneumonia

Advanced Science, EarlyView.
Nebulized BN@NF nanozymes integrate boron nanosheets with Nd‐doped iron phosphide to form a sono‐magneto‐responsive Z‐scheme heterostructure. Under ultrasound and magnetic activation, BN@NF amplifies ROS generation, eradicates bacteria, disrupts biofilms, and reshapes pulmonary inflammation through NF‐κB suppression, mitophagy promotion, and M1‐to‐M2 ...
Xiaofeng Luo, Yundi Wu, Shuai Zhang, Huanran Qu, Shiyang Shao, Jianqiang Chen, Xilong Wu   +6 more
wiley   +1 more source

Lactylation‐Driven PROS1‐TYRO3‐CARF Signaling Promotes Therapy‐Induced Senescence Escape and Radioresistance in Meningioma

Advanced Science, EarlyView.
A glycolysis‐driven epigenetic switch promotes therapy resistance in meningioma. Increased lactate production enhances histone H3K27 lactylation, which activates PROS1 secretion. Secreted PROS1 engages TYRO3 signaling to degrade the senescence regulator CARF, allowing cancer cells to escape growth arrest.
Zhuohang Wang, Qixiang Zhang, Keman Liao, Xiaoyu Liu, Hongchi Zhang, Yunsheng Chen, Yuxiao Ma, Yikui Liu, Aoqian Xu, Yuhao Sun, Jiayi Chen, Liuguan Bian, Baofeng Wang   +12 more
wiley   +1 more source