Results 261 to 270 of about 2,017,768 (306)

Oncogenic forms of p53 inhibit p53-regulated gene expression

Science, 1992
Mutant forms of the gene encoding the tumor suppressor p53 are found in numerous human malignancies, but the physiologic function of p53 and the effects of mutations on this function are unknown. The p53 protein binds DNA in a sequence-specific manner and thus may regulate gene transcription.
S E, Kern, J A, Pietenpol, S, Thiagalingam, A, Seymour, K W, Kinzler, B, Vogelstein   +5 more
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Adenovirus p53 gene therapy

Expert Opinion on Biological Therapy, 2005
To date, dysfunctional tumour suppressor genes are the most common genetic lesions identified in human cancers. Functional copies of tumour suppressor genes can be introduced into cancer cells by gene transfer using adenoviral vectors. This approach has been extensively studied in the clinic with intratumoural injection of a replication-defective ...
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The functions of the p53 gene and gene product

Journal of Gastroenterology and Hepatology, 1993
Abstractp53 is a tumour suppressor protein involved in the regulation of the cell cycle. Mutation of the p53 gene and expression of mutant p53 protein are associated with many types of human neoplasia. Mutational hot spots at specific amino acid residues have been identified, and these hot spot mutations are differentially expressed in tumours of ...
R. S. QUARTIN, A. J. LEVINE
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p53 protein accumulation and p53 gene mutation in colorectal cancer

Pathology & Oncology Research, 2000
Comparison of immunohistochemical methods for detection of protein p53 accumulation and molecular techniques for analysis p53 gene mutation in colorectal cancer is presented. Thirty eight patients were included: all underwent surgery without preoperative treatment.
A, Nasierowska-Guttmejer , L, Trzeciak , M P, Nowacki , J, Ostrowski   +3 more
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p53 Expression and p53 Gene Mutation in Oral Cancer and Dysplasia

Otolaryngology–Head and Neck Surgery, 1998
BACKGROUNDThe aim of the current study was to examine the possible association of the p53 tumor suppressor gene with the development of oral cancer. We examined biopsy material from patients with oral squamous cell carcinoma for p53 protein expression and p53 mutations.METHODSEighteen samples were analyzed.
H, Rowley, P, Sherrington, T R, Helliwell, A, Kinsella, A S, Jones   +4 more
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p53 gene mutation in thyroid carcinoma

Cancer Letters, 1996
The pattern of p53 protein expression was examined in 92 cases of thyroid carcinoma. When the cases were divided into two groups with regard to their cytoplasmic staining only or nucleus staining only, the frequency of the nucleus staining group was significantly higher in the poorly differentiated carcinoma (PDC) and undifferentiated carcinoma (UDC ...
Y S, Ho, S C, Tseng, T Y, Chin, L L, Hsieh, J D, Lin   +4 more
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p53 gene mutations in gastric adenomas

Virchows Archiv B Cell Pathology Including Molecular Pathology, 1993
p53 gene alterations in ten gastric adenomas and one carcinoma arising in an adenoma were analyzed by deoxynucleotide sequencing. Three (30%) of the ten gastric adenomas had p53 gene mutations, one adenoma showing a frameshift mutation and two others showing silent mutations.
H, Tohdo, H, Yokozaki, K, Haruma, G, Kajiyama, E, Tahara   +4 more
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The p53 Gene and Cancer

2019
This tutorial describes the structure and function of the p53 protein, how its activity is regulated in cells, and how mutant versions of p53 can lead to cancer.
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p53 gene therapy for esophageal cancer

Journal of Gastroenterology, 2002
Despite improvement of surgical treatment and application of multimodality therapies to advanced esophageal cancer, the prognosis is extremely poor for patients with unresectable tumors. Based on the genetic background of esophageal cancer, we have developed various gene therapy strategies against human esophageal cancer.
Hideaki, Shimada, Hisahiro, Matsubara, Takenori, Ochiai   +2 more
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Mutagenesis in the P53 gene

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1997
G P, Pfeifer, G P, Holmquist
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