Results 241 to 250 of about 2,017,768 (306)

Inactivation of CDKN2AARF Promotes p53-Independent Remodeling of the PDAC Tumor Microenvironment. [PDF]

Cancer Res
Ferreira S, Flowers BM, Choi WY, Farina-Morillas M, Gatto A, Bhattacharyya S, Boross G, Hassan G, Mulligan AS, Vogel H, Wood LD, Weaver VM, Winslow MM, Petrov DA, Sherman MH, Choi HY, Hayes DN, Aguirre AJ, Seoane JA, Attardi LD.   +19 more
europepmc   +1 more source

The Antidiabetic Potential of Alpha‐Mangostin: A Review of Preclinical and Clinical Evidence

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Alpha‐mangostin is a compound from the pericarp of Garcinia mangostana. The antidiabetic effects of alpha‐mangostin include enhancing insulin secretion, improving glucose uptake through GLUT receptor upregulation, reducing oxidative stress and inflammation, promoting wound healing, reducing HbA1C, reducing HOMA‐IR index, and decreased mRNA expressions ...
Oliver Dean John, Nur Damia Iwani Zulkiflee, Siti Raihanah Shafie, Ramlah George, Melonney Patrick   +4 more
wiley   +1 more source

Development of an immunocompetent cutaneous squamous cell carcinoma model identifies VISTA and CTLA-4 as targetable immune checkpoints. [PDF]

J Immunother Cancer
Rodriguez Rosario AE, Rangel R, Balbin N, Nizami ZN, Hadi J, Noor A, Dong L, Corona A, Bhavani N, Cruz Sanchez RM, Sunga GM, Veeramachaneni R, Manyam GC, Wang J, Yu W, Sikora AG, N Myers J, Rangel R.   +17 more
europepmc   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

From Molecular Classification to Hereditary Cancer Syndrome Identification in Endometrial Cancer. [PDF]

Genes (Basel)
Libera L, Carnevali I, Facchi S, Sahnane N, Travaglino A, La Rosa S, Tibiletti MG.   +6 more
europepmc   +1 more source

Long Noncoding RNAs in Aortic Dissection: Mechanistic Roles and Therapeutic Potential

AGING MEDICINE, EarlyView.
Aortic dissection (AD) involves vascular inflammation, VSMC dysfunction, and ECM degradation. LncRNAs regulate AD progression via ceRNA networks, with great potential as diagnostic biomarkers and therapeutic targets, while further clinical validation is needed.
Chao Chang, Yongrong Lan, Zhenhua Wu, Jie Geng, Zhigang Guo, Qingliang Chen   +5 more
wiley   +1 more source

Molecular classification of endometrial carcinoma: clinical utility of an NGS panel with targeted detection of 116 cancer-related genes. [PDF]

Pathol Oncol Res
Chen L, You Z, Yu X, Wu Y, Chen X, Lin J.   +5 more
europepmc   +1 more source

A Multistrategy AI‐Assisted Consensus Screening Pipeline for Discovery of Candidate p53 Monomer Binders

Advanced Intelligent Discovery, EarlyView.
An ultra‐fast small‐sample AI consensus pipeline combines co‐folding and docking to target structure‐lacking p53 monomers. Its optimal mini‐protein binder shows robust interfacial affinity and promising druggability, supplying unprecedented antitumor p53 templates.
Ningyao Li, Xueyi Liu, Qiuyue Li, Chengfeng Yue, Xin Li, Yugang Huang, Xin Deng, Junfei Zhang, Xue Liang, Guodong Ye   +9 more
wiley   +1 more source

Association between the expression of GSTP1 and mutant p53, poor chemotherapy response and metastasis in patients with osteosarcoma. [PDF]

Oncol Lett
Primayudha B, Kodrat E, Prabowo Y, Kurniawan A, Siregar NC, Irawan MNSB, Magetsari R, Wiratnaya IGE, Irsan II, Kamal AF.   +9 more
europepmc   +1 more source

Differential STING and p53 expression in epidermodysplasia verruciformis-associated versus non-EV cutaneous squamous cell carcinomas. [PDF]

Med Oncol
Fróes LAR, de Oliveira WRP, Stahlschmidt P, da Cruz Silva LL, Pereira NV, Sotto MN.   +5 more
europepmc   +1 more source