Results 41 to 50 of about 2,017,768 (306)

Anti-tumor drug FTY720 regulates p53-dependent transcription [PDF]

Jichu yixue yu linchuang, 2021
Objective To explore whether anti-tumor drug FTY720 participates in regulation of p53-dependent gene transcription and to evaluate the potential roles of FTY720-p53 axis in the modulation of cellular biological processes.
YAO Han, XU Wen-bin, WANG Dong-lai
doaj  

Ubiquitin ligase DTX3 empowers mutant p53 to promote ovarian cancer development

Genes and Diseases, 2022
The deltex family protein DTX3 is believed to possess E3 ubiquitin ligase activity, as it contains a classic RING finger domain. However, its biological role and the underlying mechanism in cancer remain largely elusive.
Shanshan Wang, Qian Hao, Jiajia Li, Yajie Chen, Hua Lu, Xiaohua Wu, Xiang Zhou   +6 more
doaj   +1 more source

Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs. [PDF]

, 2012
Mutation of the tumor suppressor p53 plays a major role in human carcinogenesis. Here we describe gene-targeted porcine mesenchymal stem cells (MSCs) and live pigs carrying a latent TP53(R167H) mutant allele, orthologous to oncogenic human mutant TP53 ...
Eckhard Wolf, Marlene Edlinger, Marlene Edlinger (133272), Eckhard Wolf (39870), Krzysztof Flisikowski (133283), Mayuko Kurome, Claudia Merkl (133270), Kurome, Mayuko, Claudia Merkl, Alexander Kind, Valeri Zakhartchenko, Flisikowski, Krzysztof, Simon Leuchs (133268), Nousin Rezaei, Anja Saalfrank, Valeri Zakhartchenko (133278), Marina Durkovic (133273), Marina Durkovic, Krzysztof Flisikowski, Flisikowska, Tatiana, Kessler, Barbara, Saalfrank, Anja, Merkl, Claudia, Schnieke, Angelika, Simon Leuchs, Kind, Alexander, Zakhartchenko, Valeri, Barbara Kessler (133280), Alexander Kind (133287), Edlinger, Marlene, Mayuko Kurome (133277), Wolf, Eckhard, Rezaei, Nousin, Nousin Rezaei (133275), Angelika Schnieke (133290), Tatiana Flisikowska, Angelika Schnieke, Anja Saalfrank (133269), Tatiana Flisikowska (133271), Barbara Kessler, Leuchs, Simon, Durkovic, Marina   +41 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

p53DINP1, a p53-Inducible Gene, Regulates p53-Dependent Apoptosis [PDF]

Molecular Cell, 2001
Using the differential display method combined with a cell line that carries a well-controlled expression system for wild-type p53, we isolated a p53-inducible gene, termed p53DINP1 (p53-dependent damage-inducible nuclear protein 1). Cell death induced by DNA double-strand breaks (DSBs), as well as Ser46 phosphorylation of p53 and induction of p53AIP1,
Okamura, Shu, Arakawa, Hirofumi, Tanaka, Tomoaki, Nakanishi, Hiroshi, Ng, Ching Ching, Taya, Yoichi, Monden, Morito, Nakamura, Yusuke   +7 more
openaire   +2 more sources

Exclusive Association of p53 Mutation with Super-High Methylation of Tumor Suppressor Genes in the p53 Pathway in a Unique Gastric Cancer Phenotype.

PLoS ONE, 2015
BackgroundA comprehensive search for DNA methylated genes identified candidate tumor suppressor genes that have been proven to be involved in the apoptotic process of the p53 pathway.
Mina Waraya, Keishi Yamashita, Akira Ema, Natsuya Katada, Shiro Kikuchi, Masahiko Watanabe   +5 more
doaj   +1 more source

Molecular basis for modulation of the p53 target selectivity by KLF4 [PDF]

, 2012
The tumour suppressor p53 controls transcription of various genes involved in apoptosis, cell-cycle arrest, DNA repair and metabolism. However, its DNA-recognition specificity is not nearly sufficient to explain binding to specific locations in vivo ...
Daniel P. Teufel, Fiona M. Townsley (123705), Stefan M. V. Freund (123709), Stefan M V Freund, Teufel, Daniel P., Stefan M. V. Freund, Daniel P. Teufel (123707), Tobias Br, Tobias Brandt (123703), Townsley, Fiona M., Dmitry B Veprintsev, Veprintsev, Dmitry B., Fiona M. Townsley, Tobias Brandt, Dmitry B. Veprintsev (109095), Freund, Stefan M. V., Daniel P Teufel, Fiona M Townsley, Dmitry B. Veprintsev, Brandt, Tobias   +19 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

P53 mutations in human adrenocortical neoplasms [PDF]

, 1994
The mechanisms of tumorigenesis of adrenocortical neoplasms have not been elucidated as yet. However, loss of heterozygosity at chromosomal locus 17p has been consistently observed in adrenocortical cancer.
Travis, W., Linehan, M., Karl, M., Chrousos, G. P., Allolio, B., Mastorakis, G., Reincke, Martin   +6 more
core   +1 more source

The Transcriptional Landscape of p53 Signalling Pathway

EBioMedicine, 2017
Although recent cancer genomics studies have identified a large number of genes that were mutated in human cancers, p53 remains as the most frequently mutated gene.
Chizu Tanikawa, Yao-zhong Zhang, Ryuta Yamamoto, Yusuke Tsuda, Masami Tanaka, Yuki Funauchi, Jinichi Mori, Seiya Imoto, Rui Yamaguchi, Yusuke Nakamura, Satoru Miyano, Hidewaki Nakagawa, Koichi Matsuda   +12 more
doaj   +1 more source