Results 21 to 30 of about 255,591 (268)
p32 is a negative regulator of p53 tetramerization and transactivation
Molecular Oncology, 2019 p53 is a sequence‐specific transcription factor, and proper regulation of p53 transcriptional activity is critical for orchestrating different tumor‐suppressive mechanisms.
Nikhil Baban Ghate +5 more
doaj +1 more source
Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage
BMC Cell Biology, 2009 Background P53 is a key tumor suppressor protein. In response to DNA damage, p53 accumulates to high levels in differentiated cells and activates target genes that initiate cell cycle arrest and apoptosis.
Rolletschek Alexandra +2 more
doaj +1 more source
p53DINP1, a p53-Inducible Gene, Regulates p53-Dependent Apoptosis [PDF]
Molecular Cell, 2001 Using the differential display method combined with a cell line that carries a well-controlled expression system for wild-type p53, we isolated a p53-inducible gene, termed p53DINP1 (p53-dependent damage-inducible nuclear protein 1). Cell death induced by DNA double-strand breaks (DSBs), as well as Ser46 phosphorylation of p53 and induction of p53AIP1,
Okamura, Shu +7 more
openaire +2 more sources
Role of p53 Serine 46 in p53 Target Gene Regulation [PDF]
PLoS ONE, 2011 The tumor suppressor p53 plays a crucial role in cellular growth control inducing a plethora of different response pathways. The molecular mechanisms that discriminate between the distinct p53-responses have remained largely elusive. Here, we have analyzed the p53-regulated pathways induced by Actinomycin D and Etoposide treatment resulting in more ...
Smeenk, Leonie +6 more
openaire +6 more sources
Cell Reports, 2018 Summary: Understanding how p53 activates certain gene programs and not others is critical. Here, we identify low-density lipoprotein receptor-related protein 1 (LRP1), a transmembrane endocytic receptor, as a p53 target gene.
Patrick L. Leslie +3 more
doaj +1 more source
A p53 drug response signature identifies prognostic genes in high-risk neuroblastoma. [PDF]
PLoS ONE, 2013 Chemotherapy induces apoptosis and tumor regression primarily through activation of p53-mediated transcription. Neuroblastoma is a p53 wild type malignancy at diagnosis and repression of p53 signaling plays an important role in its pathogenesis. Recently
Eveline Barbieri +9 more
doaj +1 more source
p53 gene mutation: software and database [PDF]
Nucleic Acids Research, 1996 A large number of different mutations in the tumor suppressor gene p53 gene have been identified in all types of cancer. As of September 1995, this database contains over 4200 mutations. This substantial increase since our previous report can enable epidemiological analyses which were not previously possible. In order to capture all these new data, the
Christophe Béroud +2 more
openaire +4 more sources
BMC Cancer, 2011 Background Metastatic melanoma represents a major clinical problem. Its incidence continues to rise in western countries and there are currently no curative treatments. While mutation of the P53 tumour suppressor gene is a common feature of many types of
Rizos Helen +10 more
doaj +1 more source
Ubiquitin ligase DTX3 empowers mutant p53 to promote ovarian cancer development
Genes and Diseases, 2022 The deltex family protein DTX3 is believed to possess E3 ubiquitin ligase activity, as it contains a classic RING finger domain. However, its biological role and the underlying mechanism in cancer remain largely elusive.
Shanshan Wang +6 more
doaj +1 more source
Mutations of the p53 gene in lymphoid leukemia [PDF]
Blood, 1991 p53 is currently considered to be a tumor suppressor gene product, and its alterations are suggested to be involved in several human malignancies. Here we show evidence of the possible involvement of p53 gene mutations in lymphoid leukemias studied by reverse transcriptase- polymerase chain reaction, single strand conformation polymorphism analysis ...
F.Takaku +7 more
openaire +3 more sources