Results 21 to 30 of about 2,017,768 (306)
A Comprehensive and High-Resolution Genome-wide Response of p53 to Stress
Cell Reports, 2014 Tumor suppressor p53 regulates transcription of stress-response genes. Many p53 targets remain undiscovered because of uncertainty as to where p53 binds in the genome and the fact that few genes reside near p53-bound recognition elements (REs).
Gue Su Chang +11 more
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Gene expression profiles resulting from stable loss of p53 mirrors its role in tissue differentiation. [PDF]
PLoS ONE, 2013 The tumor suppressor gene p53 is involved in a variety of cellular activities such as cellular stress responses, cell cycle regulation and differentiation.
Oliver Couture +4 more
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Insights into Regulators of p53 Acetylation
Cells, 2022 The tumor suppressor p53 is a transcription factor that regulates the expression of dozens of target genes and diverse physiological processes. To precisely regulate the p53 network, p53 undergoes various post-translational modifications and alters the ...
Mai Nagasaka +6 more
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Multiple C-terminal Lysine residues target p53 for ubiquitin-proteasome-mediated degradation [PDF]
, 2000 This work was supported by the Medical Research Council, the Biotechnology and Biological Research Council, and the Cancer Research Campaign. D.P.L. is a Gibb fellow of the Cancer Research Campaign.In normal cells, p53 is maintained at a low level by ...
Lain, Sonia +6 more
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Is p53 a Breast Cancer Gene? [PDF]
Cancer Biology & Therapy, 2002 No Abstract AvailableCommentary to: Title: Mutations in the p53 Tumor Suppressor Gene and Early Onset Breast CancerAuthors: Hong Lai, Lin Lin, Mehrdad Nadji, Shenghan Lai, Edward Trapido and Lou MengPage Numbers: 31 ...
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Targeting mutant p53 for cancer therapy: direct and indirect strategies
Journal of Hematology & Oncology, 2021 TP53 is a critical tumor-suppressor gene that is mutated in more than half of all human cancers. Mutations in TP53 not only impair its antitumor activity, but also confer mutant p53 protein oncogenic properties.
Jiahao Hu +9 more
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Deficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFβ cell cycle arrest [PDF]
, 2007 Background TGFβ is critical to control hepatocyte proliferation by inducing G1-growth arrest through multiple pathways leading to inhibition of E2F transcription activity.
Dunbar, Donald R +14 more
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The Emerging p53 Gene Family [PDF]
JNCI Journal of the National Cancer Institute, 1999 Perturbation of p53 protein function is a common, if not universal, finding in human cancer. Tumor suppression by p53 is due, at least in part, to its ability to activate transcription of certain genes involved in cell cycle control and apoptosis (programmed cell death).
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p32 is a negative regulator of p53 tetramerization and transactivation
Molecular Oncology, 2019 p53 is a sequence‐specific transcription factor, and proper regulation of p53 transcriptional activity is critical for orchestrating different tumor‐suppressive mechanisms.
Nikhil Baban Ghate +5 more
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Point mutations of the P53 gene, human hepatocellular carcinoma and aflatoxins [PDF]
, 1993 The tumor suppressor p53 exerts important protective functions towards DNA-damaging agents. Its inactivation by allelic deletions or point mutations within the P53 gene as well as complex formation of wildtype p53 with cellular or viral proteins is a ...
Caselmann, Wolfgang H. +1 more
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