Results 21 to 30 of about 2,151,650 (259)

Insights into Regulators of p53 Acetylation

Cells, 2022
The tumor suppressor p53 is a transcription factor that regulates the expression of dozens of target genes and diverse physiological processes. To precisely regulate the p53 network, p53 undergoes various post-translational modifications and alters the ...
Mai Nagasaka, Chiharu Miyajima, Hiromasa Aoki, Mineyoshi Aoyama, Daisuke Morishita, Yasumichi Inoue, Hidetoshi Hayashi   +6 more
doaj   +1 more source

Deficiency of G1 regulators P53, P21^Cip1 and/or pRb decreases hepatocyte sensitivity to TGFβ cell cycle arrest [PDF]

, 2007
Background TGFβ is critical to control hepatocyte proliferation by inducing G1-growth arrest through multiple pathways leading to inhibition of E2F transcription activity.
Dunbar, Donald R, Sharon Sheahan, Harrison David J, Harrison, David J, David J Harrison, Bellamy, Christopher O, Dunbar Donald R, Prost Sandrine, Sandrine Prost, Donald R Dunbar, Christopher O Bellamy, Sheahan Sharon, Sheahan, Sharon, Bellamy Christopher O, Prost, Sandrine, Harrison, David J; id_orcid   +15 more
core   +2 more sources

Targeting mutant p53 for cancer therapy: direct and indirect strategies

Journal of Hematology & Oncology, 2021
TP53 is a critical tumor-suppressor gene that is mutated in more than half of all human cancers. Mutations in TP53 not only impair its antitumor activity, but also confer mutant p53 protein oncogenic properties.
Jiahao Hu, Jiasheng Cao, Win Topatana, Sarun Juengpanich, Shijie Li, Bin Zhang, Jiliang Shen, Liuxin Cai, Xiujun Cai, Mingyu Chen   +9 more
doaj   +1 more source

Molecular basis for modulation of the p53 target selectivity by KLF4 [PDF]

, 2012
The tumour suppressor p53 controls transcription of various genes involved in apoptosis, cell-cycle arrest, DNA repair and metabolism. However, its DNA-recognition specificity is not nearly sufficient to explain binding to specific locations in vivo ...
Daniel P. Teufel, Fiona M. Townsley (123705), Stefan M. V. Freund (123709), Stefan M V Freund, Teufel, Daniel P., Stefan M. V. Freund, Daniel P. Teufel (123707), Tobias Br, Tobias Brandt (123703), Townsley, Fiona M., Dmitry B Veprintsev, Veprintsev, Dmitry B., Fiona M. Townsley, Tobias Brandt, Dmitry B. Veprintsev (109095), Freund, Stefan M. V., Daniel P Teufel, Fiona M Townsley, Dmitry B. Veprintsev, Brandt, Tobias, Townsley, Fiona M. (author), Freund, Stefan M.V. (author), Teufel Daniel P., Brandt, Tobias (author), Teufel, Daniel P. (author), Townsley Fiona M., Brandt Tobias, Veprintsev, Dmitry B. (author), Veprintsev Dmitry B., Freund Stefan M. V.   +29 more
core   +2 more sources

Multiple C-terminal Lysine residues target p53 for ubiquitin-proteasome-mediated degradation [PDF]

, 2000
This work was supported by the Medical Research Council, the Biotechnology and Biological Research Council, and the Cancer Research Campaign. D.P.L. is a Gibb fellow of the Cancer Research Campaign.In normal cells, p53 is maintained at a low level by ...
Lain, Sonia, Lane, David P., T. Hay, Ronald, Hay, Ronald Thomas, Rodriguez, Manuel S, Desterro, Joana M P   +6 more
core   +1 more source

p32 is a negative regulator of p53 tetramerization and transactivation

Molecular Oncology, 2019
p53 is a sequence‐specific transcription factor, and proper regulation of p53 transcriptional activity is critical for orchestrating different tumor‐suppressive mechanisms.
Nikhil Baban Ghate, Jinman Kim, Yonghwan Shin, Alan Situ, Tobias S. Ulmer, Woojin An   +5 more
doaj   +1 more source

Point mutations of the P53 gene, human hepatocellular carcinoma and aflatoxins [PDF]

, 1993
The tumor suppressor p53 exerts important protective functions towards DNA-damaging agents. Its inactivation by allelic deletions or point mutations within the P53 gene as well as complex formation of wildtype p53 with cellular or viral proteins is a ...
Caselmann, Wolfgang H., Gerbes, Alexander L.   +1 more
core   +1 more source

Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage

BMC Cell Biology, 2009
Background P53 is a key tumor suppressor protein. In response to DNA damage, p53 accumulates to high levels in differentiated cells and activates target genes that initiate cell cycle arrest and apoptosis.
Rolletschek Alexandra, Solozobova Valeriya, Blattner Christine   +2 more
doaj   +1 more source

The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a. [PDF]

, 2014
p53 and its major E3 ligase Mdm2 are both ubiquitinated and targeted to the proteasome for degradation. Despite the importance of this in regulating the p53 pathway, little is known about the mechanisms of proteasomal recognition of ubiquitinated p53 and
J Das, S Menendez, Menendez, S., Saville, M. K., S Dayal, Das, J., M K Saville, Dayal, S., A Sparks, Robertson, P., P Robertson, Sparks, A.   +11 more
core   +1 more source

Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity [PDF]

, 2011
MicroRNAs (miRNAs) interact with 3'-untranslated regions of messenger RNAs to restrict expression of most protein-coding genes during normal development and cancer. RNA-binding proteins (RBPs) can control the biogenesis, stability and activity of miRNAs.
Horlings, HM, Agami, R, Manoharan, Vijayalaxmi, Elkon, Ran, Hollingworth, D, Ramos, A, Jelle Wesseling, Melo, CA, Esteller, M, Jernej Ule, Ran Elkon, Manoharan, V, Davalos, V, Horlings, Hugo M., Hugo M. Horlings, Wesseling, Jelle, Manel Esteller, Esteller, Manel, Ule, Jernej, Veronica Davalos, Vijayalaxmi Manoharan, Andres Ramos, Reuven Agami, Dave Hollingworth, Oude Vrielink, J, Léveillé, N, Wesseling, J, Nicolas Léveillé, Joachim Oude Vrielink, Hollingworth, Dave, Agami, Reuven, Ule, J, Melo, Carlos A., Carlos le Sage, Elkon, R, Léveillé, Nicolas, Carlos A. Melo, le Sage, C, Davalos, Veronica, Ramos, Andres, Esteller, Manel, 1968-, Vrielink, Joachim Oude, Le Sage, Carlos   +42 more
core   +1 more source