Results 31 to 40 of about 2,151,650 (259)

p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop

Cell Reports, 2018
Summary: Understanding how p53 activates certain gene programs and not others is critical. Here, we identify low-density lipoprotein receptor-related protein 1 (LRP1), a transmembrane endocytic receptor, as a p53 target gene.
Patrick L. Leslie, Derek A. Franklin, Yong Liu, Yanping Zhang   +3 more
doaj   +1 more source

P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation

BMC Cancer, 2011
Background Metastatic melanoma represents a major clinical problem. Its incidence continues to rise in western countries and there are currently no curative treatments. While mutation of the P53 tumour suppressor gene is a common feature of many types of
Rizos Helen, Talseth-Palmer Bente A, Ashton Katie A, Kairupan Carla F, Scurr Lyndee L, Croft Amanda J, Bowden Nikola A, Avery-Kiejda Kelly A, Zhang Xu D, Scott Rodney J, Hersey Peter   +10 more
doaj   +1 more source

A p53 drug response signature identifies prognostic genes in high-risk neuroblastoma. [PDF]

PLoS ONE, 2013
Chemotherapy induces apoptosis and tumor regression primarily through activation of p53-mediated transcription. Neuroblastoma is a p53 wild type malignancy at diagnosis and repression of p53 signaling plays an important role in its pathogenesis. Recently
Eveline Barbieri, Katleen De Preter, Mario Capasso, Peter Johansson, Tsz-Kwong Man, Zaowen Chen, Paris Stowers, Gian Paolo Tonini, Frank Speleman, Jason M Shohet   +9 more
doaj   +1 more source

Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms

eLife, 2014
The p53 transcription factor is a potent suppressor of tumor growth. We report here an analysis of its direct transcriptional program using Global Run-On sequencing (GRO-seq). Shortly after MDM2 inhibition by Nutlin-3, low levels of p53 rapidly activate ∼
Mary Ann Allen, Zdenek Andrysik, Veronica L Dengler, Hestia S Mellert, Anna Guarnieri, Justin A Freeman, Kelly D Sullivan, Matthew D Galbraith, Xin Luo, W Lee Kraus, Robin D Dowell, Joaquin M Espinosa   +11 more
doaj   +1 more source

Dissection of the functional interaction between p53 and the embryonic proto-oncoprotein PAX3

, 2007
Studies from murine embryogenesis and cancer cells derived from human melanomas have identified a critical role for the transcription factor PAX3 in the suppression of p53 protein accumulation and p53-dependent apoptosis.
Underwood, Timothy J., Jay Amin, Amin, Jay, Blaydes, Jeremy P., Timothy J. Underwood, Lillycrop, Karen A., Jeremy P. Blaydes, Karen A. Lillycrop   +7 more
core   +1 more source

FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells [PDF]

, 2011
Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that is elevated in a variety of human cancers. While FAK is implicated in many cellular processes that are perturbed in cancer, including proliferation, actin and adhesion dynamics ...
Moran-Jones Kim, Moran-Jones, K., Graham Kathryn, Brunton Valerie G., Margaret C Frame, Owen J. Sansom, Frame, Margaret C., Moran-jones, Kim, Frame, M.C., Sansom, Owen J., Owen J Sansom, Brunton, V.G., Valerie G Brunton, Frame Margaret C., Valerie G. Brunton, Margaret C. Frame, Graham, K., Brunton, Valerie G., Kathryn Graham, Graham, Kathryn, Sansom Owen J., Sansom, O.J., Kim Moran-Jones   +22 more
core   +1 more source

Ubiquitin ligase DTX3 empowers mutant p53 to promote ovarian cancer development

Genes and Diseases, 2022
The deltex family protein DTX3 is believed to possess E3 ubiquitin ligase activity, as it contains a classic RING finger domain. However, its biological role and the underlying mechanism in cancer remain largely elusive.
Shanshan Wang, Qian Hao, Jiajia Li, Yajie Chen, Hua Lu, Xiaohua Wu, Xiang Zhou   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Exclusive Association of p53 Mutation with Super-High Methylation of Tumor Suppressor Genes in the p53 Pathway in a Unique Gastric Cancer Phenotype.

PLoS ONE, 2015
BackgroundA comprehensive search for DNA methylated genes identified candidate tumor suppressor genes that have been proven to be involved in the apoptotic process of the p53 pathway.
Mina Waraya, Keishi Yamashita, Akira Ema, Natsuya Katada, Shiro Kikuchi, Masahiko Watanabe   +5 more
doaj   +1 more source

Anti-tumor drug FTY720 regulates p53-dependent transcription [PDF]

Jichu yixue yu linchuang, 2021
Objective To explore whether anti-tumor drug FTY720 participates in regulation of p53-dependent gene transcription and to evaluate the potential roles of FTY720-p53 axis in the modulation of cellular biological processes.
YAO Han, XU Wen-bin, WANG Dong-lai
doaj