Results 31 to 40 of about 2,017,768 (306)

Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage

BMC Cell Biology, 2009
Background P53 is a key tumor suppressor protein. In response to DNA damage, p53 accumulates to high levels in differentiated cells and activates target genes that initiate cell cycle arrest and apoptosis.
Rolletschek Alexandra, Solozobova Valeriya, Blattner Christine   +2 more
doaj   +1 more source

Involvement of the p53/p21 complex in p53-dependent gene expression

Biochemical and Biophysical Research Communications, 2022
The p53 tumor suppressor regulates cell functions either by acting as a transcription factor or by interacting with other proteins. Previously, we reported that the non-transcriptional actions of p53 can be facilitated by the binding of p53 to p21. Herein, we investigated whether p53/p21 interaction influences the transcriptional activity of p53.
Ukjin Kim, Kwang Seok Kim, Jong-Kuk Park, Hong-Duck Um   +3 more
openaire   +2 more sources

Modulation of Lung Adenocarcinoma by Phosphorylated FOXN3-Mediated Transcriptional Inactivation of p53. [PDF]

Adv Sci (Weinh)
In non‐tumorous lung tissues, FOXN3 promotes the transcriptional activation of p53 by facilitating its recruitment to target promoters, thereby suppressing lung tumorigenesis through activation of the p53 signaling pathway. Conversely, in lung adenocarcinoma tissues, hyperphosphorylated FOXN3 dissociates from the promoters of p53‐responsive genes and ...
Yu J, Yu J, Wang S, Hu X, Jin L, Wu N, Ni Y, Zhang X, Zhao C, Zhou J, Zhang Y, Sun B, Zhang H, Zheng C, Zheng SG, Li W, Zhu X.   +16 more
europepmc   +2 more sources

Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathways [PDF]

, 2013
The DNA-damaging agent camptothecin (CPT) and its analogs demonstrate clinical utility for the treatment of advanced solid tumors, and CPT-based nanopharmaceuticals are currently in clinical trials for advanced kidney cancer; however, little is known ...
Ashcroft, M, Carroll, VA, Selvarajah, J, Moumen, A, Nathawat, K   +4 more
core   +2 more sources

p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop

Cell Reports, 2018
Summary: Understanding how p53 activates certain gene programs and not others is critical. Here, we identify low-density lipoprotein receptor-related protein 1 (LRP1), a transmembrane endocytic receptor, as a p53 target gene.
Patrick L. Leslie, Derek A. Franklin, Yong Liu, Yanping Zhang   +3 more
doaj   +1 more source

The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a. [PDF]

, 2014
p53 and its major E3 ligase Mdm2 are both ubiquitinated and targeted to the proteasome for degradation. Despite the importance of this in regulating the p53 pathway, little is known about the mechanisms of proteasomal recognition of ubiquitinated p53 and
J Das, S Menendez, Menendez, S., Saville, M. K., S Dayal, Das, J., M K Saville, Dayal, S., A Sparks, Robertson, P., P Robertson, Sparks, A.   +11 more
core   +1 more source

P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation

BMC Cancer, 2011
Background Metastatic melanoma represents a major clinical problem. Its incidence continues to rise in western countries and there are currently no curative treatments. While mutation of the P53 tumour suppressor gene is a common feature of many types of
Rizos Helen, Talseth-Palmer Bente A, Ashton Katie A, Kairupan Carla F, Scurr Lyndee L, Croft Amanda J, Bowden Nikola A, Avery-Kiejda Kelly A, Zhang Xu D, Scott Rodney J, Hersey Peter   +10 more
doaj   +1 more source

A p53 drug response signature identifies prognostic genes in high-risk neuroblastoma. [PDF]

PLoS ONE, 2013
Chemotherapy induces apoptosis and tumor regression primarily through activation of p53-mediated transcription. Neuroblastoma is a p53 wild type malignancy at diagnosis and repression of p53 signaling plays an important role in its pathogenesis. Recently
Eveline Barbieri, Katleen De Preter, Mario Capasso, Peter Johansson, Tsz-Kwong Man, Zaowen Chen, Paris Stowers, Gian Paolo Tonini, Frank Speleman, Jason M Shohet   +9 more
doaj   +1 more source

Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms

eLife, 2014
The p53 transcription factor is a potent suppressor of tumor growth. We report here an analysis of its direct transcriptional program using Global Run-On sequencing (GRO-seq). Shortly after MDM2 inhibition by Nutlin-3, low levels of p53 rapidly activate ∼
Mary Ann Allen, Zdenek Andrysik, Veronica L Dengler, Hestia S Mellert, Anna Guarnieri, Justin A Freeman, Kelly D Sullivan, Matthew D Galbraith, Xin Luo, W Lee Kraus, Robin D Dowell, Joaquin M Espinosa   +11 more
doaj   +1 more source

p53 Expression in Colorectal Carcinoma in Relation to Histopathological Features in Ugandan Patients. [PDF]

, 2008
It has been shown that colorectal carcinoma is increasing in incidence in African countries. This could be due to change in life style. Molecular pathogenesis of colorectal cancer commonly involves mutation in p53 gene which leads to expression of p53 ...
Rambau, PF, Rambau, Peter F., Rambau, Peter F, Odida, Michael, Wabinga, Henry, Odida, M, Wabinga, H   +6 more
core   +1 more source