Results 11 to 20 of about 255,591 (268)
Characterization of the human p53 gene. [PDF]
Molecular and Cellular Biology, 1986 Cosmid and lambda clones containing the human p53 gene were isolated and characterized in detail. The gene is 20 kilobases (kb) long and has 11 exons, the first and second exons being separated by an intron of 10 kb. Restriction fragments upstream of sequences known to be within the first identified exon were tested for promoter activity by cloning ...
P, Lamb, L, Crawford
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Oncogene, 1999 p73 and p63 are two recently discovered p53 homologs. Like p53, these proteins can recognize canonical p53 DNA-binding sites and, when overproduced, can activate p53-responsive target genes and induce apoptosis. Unlike p53, these genes undergo complex alternative splicing which, at least in the case of p63, yields proteins with widely divergent ...
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Biomédica: revista del Instituto Nacional de Salud, 2010 Introducción. El TP53 es un gen supresor de tumores localizado en la región cromosómica 17p13.1; controla el ciclo celular y se encuentra alterado en cerca de 50% de todas las neoplasias. Objetivos.
Juan Carlos Herrera +4 more
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The Emerging p53 Gene Family [PDF]
JNCI Journal of the National Cancer Institute, 1999 Perturbation of p53 protein function is a common, if not universal, finding in human cancer. Tumor suppression by p53 is due, at least in part, to its ability to activate transcription of certain genes involved in cell cycle control and apoptosis (programmed cell death).
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A Comprehensive and High-Resolution Genome-wide Response of p53 to Stress
Cell Reports, 2014 Tumor suppressor p53 regulates transcription of stress-response genes. Many p53 targets remain undiscovered because of uncertainty as to where p53 binds in the genome and the fact that few genes reside near p53-bound recognition elements (REs).
Gue Su Chang +11 more
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Gene expression profiles resulting from stable loss of p53 mirrors its role in tissue differentiation. [PDF]
PLoS ONE, 2013 The tumor suppressor gene p53 is involved in a variety of cellular activities such as cellular stress responses, cell cycle regulation and differentiation.
Oliver Couture +4 more
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Insights into Regulators of p53 Acetylation
Cells, 2022 The tumor suppressor p53 is a transcription factor that regulates the expression of dozens of target genes and diverse physiological processes. To precisely regulate the p53 network, p53 undergoes various post-translational modifications and alters the ...
Mai Nagasaka +6 more
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Is p53 a Breast Cancer Gene? [PDF]
Cancer Biology & Therapy, 2002 No Abstract AvailableCommentary to: Title: Mutations in the p53 Tumor Suppressor Gene and Early Onset Breast CancerAuthors: Hong Lai, Lin Lin, Mehrdad Nadji, Shenghan Lai, Edward Trapido and Lou MengPage Numbers: 31 ...
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Targeting mutant p53 for cancer therapy: direct and indirect strategies
Journal of Hematology & Oncology, 2021 TP53 is a critical tumor-suppressor gene that is mutated in more than half of all human cancers. Mutations in TP53 not only impair its antitumor activity, but also confer mutant p53 protein oncogenic properties.
Jiahao Hu +9 more
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Involvement of the p53/p21 complex in p53-dependent gene expression
Biochemical and Biophysical Research Communications, 2022 The p53 tumor suppressor regulates cell functions either by acting as a transcription factor or by interacting with other proteins. Previously, we reported that the non-transcriptional actions of p53 can be facilitated by the binding of p53 to p21. Herein, we investigated whether p53/p21 interaction influences the transcriptional activity of p53.
Ukjin Kim +3 more
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