Results 91 to 100 of about 373,131 (211)

Monitoring ctDNA RAS Mutational Status in Metastatic Colorectal Cancer: A Trial Protocol of RAS-trace and RAS-trace-2 Studies

Journal of the Anus, Rectum and Colon
Background: Spatial and temporal heterogeneities of RAS and other molecular genes should be considered in the treatment of metastatic colorectal cancer (mCRC) treated with anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (mAbs ...
Kozo Kataoka, Takeshi Yamada, Manabu Shiozawa, Naoto Takase, Kazuma Ito, Kentaro Yamazaki, Jun Watanabe, Toshihiro Kudo, Takeshi Suto, Toshihiko Matsumoto, Kohei Murata, Yusuke Suwa, Shogen Boku, Hisateru Yasui, Nobuhisa Matsuhashi, Atsuyuki Maeda, Kiichi Sugimoto, Yusuke Matsumoto, Mitsuru Yokota, Johannes Fredebohm, Keita Mori, Masataka Ikeda   +21 more
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INFLUENCE OF THE POLYMORPHISM OF THE RENIN-ANGIOTENSIN SYSTEM GENES ON THE CARDIAC ARRHYTHMIAS IN CHILDREN WITH HYPERTROPHIC CARDIOMYOPATHY

Вопросы современной педиатрии, 2013
Hypertrophic cardiomyopathy (HCMP) is a genetically determined myocardial disease, characterized by massive hypertrophy of the myocardium of the left and/or (rarely) the right ventricle, often associated with obstruction of the left ventricular outflow ...
N. A. Berezneva, S. Yu. Nemtseva, O. E. Gromyko, N. S. Aver'yanova, N. D. Vashakhmadze, E. N. Basargina, V. G. Pinelis   +6 more
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MUTATIONS OF RAS GENES IN HUMAN TUMORS (REVIEW)

International Journal of Oncology, 1995
Ras family genes (H-, K- and N-ras) are implicated in a wide range of human rumours. Mutations are a major activating mechanism for the ras family genes, mainly in codons 12, 13 and 61, resulting in their conversion from proto-oncogenes to activated oncogenes.
Kiaris, H., Spandidos, Demetrios A.
openaire   +3 more sources

Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis [PDF]

, 2008
Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed to contribute.
Anura Hewagama, Bruce C. Richardson, Dipak Patel, Faith M. Strickland, Sushma Yarlagadda   +4 more
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RAS oncogenes direct metastasis

Molecular & Cellular Oncology, 2017
RAS genes are cardinal driver oncogenes frequently and differentially mutated across bodily tumors. Their tumorigenic potential has been mainly ascribed to autonomous promotion of tumor cell proliferation and survival. However, recent evidence shows that
Magda Spella, Antonia Marazioti, Kristina A. M. Arendt, Georgios T. Stathopoulos   +3 more
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ras gene mutations in human endometrial carcinoma.

Oncology, 1996
The purpose of this study was to assess the extent of involvement of the ras oncogene activation by point mutations in endometrial carcinoma in the Greek population. The PCR technique was employed, followed by RFLP analysis to identify the point mutations in codon 12 of the K-ras, H-ras and N-ras genes.
Varras, M.N., Koffa, M., Koumantakis, E., Ergazaki, M., Protopapa, E., Michalas, S., Spandidos, D.A.   +6 more
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Salirasib Inhibits the Expression of Genes Involved in Fibrosis in Fibroblasts of Systemic Sclerosis Patients

Immunity, Inflammation and Disease
Background Fibrosis is a principal sign of systemic sclerosis (SSc) which can affect several organs including the lung, heart, and dermis. Dermal fibroblasts of SSc patients are characterized by persistent and activated Ras and ERK1/2 signaling which ...
Mina Sadeghi Shaker, Mohsen Rokni, Hoda Kavosi, Samaneh Enayati, Elham Madreseh, Mahdi Mahmoudi, Elham Farhadi, Mohammad Vodjgani   +7 more
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Translational Oncogenomics and Human Cancer Interactome Networks [PDF]

, 2011
An overview of translational, human oncogenomics, transcriptomics and cancer interactomic networks is presented together with basic concepts and potential, new applications to Oncology and Integrative Cancer Biology.
I. C. Baianu
core   +1 more source

RAS Family Gene [PDF]

, 2020
openaire   +1 more source

Transfection of the H-RAS gene produces genomic instability in the MOLT-4 cell line

Revista Médica del Hospital General de México
Objective: The aim of this study was to evaluate the effect of the normal and mutated H-RAS gene on genomic instability and apoptosis in MOLT-4 cells. Material and methods: The MOLT-4 cells were cultured and DNA was extracted.
Brain O. Martínez-Esquivel, Miguel A. Baltasar-González, Víctor Corona-Montes, Jorge A. Zamora-Domínguez   +3 more
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