Results 161 to 170 of about 373,131 (211)
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2014
The three RAS genes (HRAS, KRAS, and NRAS) comprise the most commonly mutated oncogene family in human cancer. RAS genes encode highly related small GTPases that are key regulators of cytoplasmic signaling networks that include the Raf-MEK-ERK mitogen-activated protein kinase cascade and the PI3K-Akt signaling cascade. There is increasing evidence that
Tikvah K. Hayes +3 more
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The three RAS genes (HRAS, KRAS, and NRAS) comprise the most commonly mutated oncogene family in human cancer. RAS genes encode highly related small GTPases that are key regulators of cytoplasmic signaling networks that include the Raf-MEK-ERK mitogen-activated protein kinase cascade and the PI3K-Akt signaling cascade. There is increasing evidence that
Tikvah K. Hayes +3 more
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Incidence of ras gene mutations in neuroblastoma
European Journal of Pediatrics, 1988Using a rapid dot-blot screening procedure based on DNA amplification and hybridization to synthetic oligonucleotide probes, we investigated 18 neuroblastomas in various clinical stages for the presence of ras mutations. In none of the samples was a mutation in the relevant codons 12, 13 or 61 of Ha-ras, Ki-ras or N-ras found.
K, Ballas +3 more
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Cancer surveys, 1987
Members of the ras multigene family have been found in virtually all eukaryotes, from yeast to mammals. ras is required for normal cell growth in the yeast Saccharomyces cerevisiae and in at least some mammalian cells. These genes induce tumorigenic transformation of established NIH 3T3 cells by increased expression of a normal ras gene, certain point ...
D R, Lowy, B M, Willumsen
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Members of the ras multigene family have been found in virtually all eukaryotes, from yeast to mammals. ras is required for normal cell growth in the yeast Saccharomyces cerevisiae and in at least some mammalian cells. These genes induce tumorigenic transformation of established NIH 3T3 cells by increased expression of a normal ras gene, certain point ...
D R, Lowy, B M, Willumsen
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1986
The ras gene family in mammalian cells consists of five closely related members: the Harvey and Kirsten ras genes (c-Ha-ras1 and c-Ki-ras2), an inactive pseudogene of each (c-Ha-ras2 and c-Ki-ras1; see Hall 1984) and the N-ras gene. There are also several distinctly related genes designated rho (ras-homologous; Madaule and Axel 1985).
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The ras gene family in mammalian cells consists of five closely related members: the Harvey and Kirsten ras genes (c-Ha-ras1 and c-Ki-ras2), an inactive pseudogene of each (c-Ha-ras2 and c-Ki-ras1; see Hall 1984) and the N-ras gene. There are also several distinctly related genes designated rho (ras-homologous; Madaule and Axel 1985).
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Different Patterns of Gene Expression in ras-Resistant and ras-Sensitive Cells
JNCI Journal of the National Cancer Institute, 1991We have shown previously that nontumorigenic NIH 3T3 cells can be made tumorigenic and metastatic by transfection and expression of activated ras, whereas in LTA cells, which are tumorigenic but nonmetastatic, the degree of malignancy is not altered by ras.
A B, Tuck +3 more
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The ras gene family and human carcinogenesis
Mutation Research/Reviews in Genetic Toxicology, 1988It has been well established that specific alterations in members of the ras gene family, H-ras, K-ras and N-ras, can convert them into active oncogenes. These alterations are either point mutations occurring in either codon 12, 13 or 61 or, alternatively, a 5- to 50-fold amplification of the wild-type gene. Activated ras oncogenes have been found in a
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Pathology, research and practice, 1997
Ras gene mutations have been found with variable prevalence in different tumor types. While during the past decade a lot of information has been accumulated on the frequency of ras oncogene activation in tumors, the last two years brought considerable progress in elucidating molecular mechanisms of signal transduction for which cellular ras proteins ...
V, Waldmann, H M, Rabes
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Ras gene mutations have been found with variable prevalence in different tumor types. While during the past decade a lot of information has been accumulated on the frequency of ras oncogene activation in tumors, the last two years brought considerable progress in elucidating molecular mechanisms of signal transduction for which cellular ras proteins ...
V, Waldmann, H M, Rabes
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
exaly