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Retinoblastoma and tumor-suppressor gene therapy
Ophthalmology Clinics of North America, 2003Retinoblastoma as a genetic disease is a paradigm for tumor-suppressor gene theory. The RB gene is one of the best-studied tumor-suppressor genes with known key functions in controlling cell proliferation and differentiation. Reconstitution of RB function in RB-deficient tumor cells induces irreversible growth arrest (senescence) and inhibits ...
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The retinoblastoma gene and gene product.
Cancer surveys, 1992Retinoblastoma, an uncommon childhood cancer of the eye, sometimes occurs in families but is often sporadic. Cytological analysis suggested that the retinoblastoma gene resided on chromosome 13 band q14. Subsequent isolation of the RB gene from this locus allowed a more detailed analysis, showing that both copies of RB are mutated or lost in ...
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The retinoblastoma gene and cell growth control
Trends in Biochemical Sciences, 1990Rare diseases often provide unique and fascinating insights into the workings of biological machinery. Retinoblastoma is a good example. This hereditary disease occurs rarely (in only one out of 20,000 children), yet it opens a 'window' into the mechanisms that sit at the very center of growth control in cells throughout the body.
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Retinoblastoma: Diagnosis and Management
Ca-A Cancer Journal for Clinicians, 1982David Abramson
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In-Vitro Fertilisation and Retinoblastoma
Lancet, The, 2003Saskia M Imhof +1 more
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Genetics and Epigenetics of Human Retinoblastoma
Annual Review of Pathology: Mechanisms of Disease, 2015Claudia A. Benavente, Michael A Dyer
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