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The role of Trefoil Family Factor 1 (TFF1) as a potential marker for retinoblastoma: a systematic review and meta-analysis. [PDF]

BMC Ophthalmol
Alqedra J, Elarnaut L, Ethman AB, Elnahry AG, Serhan HA, Elhadi M.   +5 more
europepmc   +1 more source

Retinoblastoma [PDF]

Lancet, The, 2012
Retinoblastoma is the first tumor suppressor gene discovered ever. The discovery opened a new avenue in the field of oncology leading to the identification of 35 tumor suppressor genes, till date in our genome.
Brenda L. Gallie, Helen Dimaras, Kahaki Kimani   +2 more
exaly   +3 more sources

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Hypermethylation in the retinoblastoma gene is associated with unilateral, sporadic retinoblastoma

Cancer Genetics and Cytogenetics, 1997
We previously reported 9 unilateral, sporadic retinoblastomas with hypermethylation in the 5' region of the RB gene, and we found that CpG methylation in the RB promoter inhibits the binding of the retinoblastoma binding factor 1 (RBF-1) and the activating transcription factor (ATF)-like factors, thereby resulting in a considerable reduction in RB ...
N, Ohtani-Fujita, T P, Dryja, J M, Rapaport, T, Fujita, S, Matsumura, K, Ozasa, Y, Watanabe, K, Hayashi, K, Maeda, S, Kinoshita, T, Matsumura, Y, Ohnishi, Y, Hotta, R, Takahashi, M V, Kato, K, Ishizaki, M S, Sasaki, B, Horsthemke, K, Minoda, T, Sakai   +19 more
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Differential expression of genes in retinoblastoma

Clinica Chimica Acta, 2011
Retinoblastoma is a pediatric eye tumor that serves as a paradigm for understanding the genetic basis of cancer. Mutations and/or epigenetic alterations inactivating both alleles of the retinoblastoma gene (RB) are associated with retinoblastoma. There are many other genes which express differentially in the preneoplastic retinal cells after RB loss ...
Parul, Saxena, Jasbir, Kaur
openaire   +2 more sources

Retinoma, Retinocytoma, and the Retinoblastoma Gene

Archives of Ophthalmology, 1983
In this issue of theArchives, Margo et al (p 1519) described the pathologic findings in six cases of a "benign retinal tumor" that occurred in five children. Tumor samples from these patients were studied by light and electron microscopy and tested for S-100 protein, a glial-cell tissue marker.
openaire   +2 more sources

Gene Carrier Detection in Retinoblastoma

Ophthalmology, 1980
Although the presence of the retinoblastoma (RB) gene is usually made obvious by bilateral RB tumors, unaffected relatives of RB patients and unilateral RB patients may also carry the gene. Patients with 13q14 deletion have RB, and segregation of RB with markers (Q-banding and Esterase D) on chromosome 13 can be studied in some two-generation RB ...
openaire   +2 more sources

Retinoblastoma gene in malignancy

1996
The central importance of genetic damage in the development of tumors was suspected prior to the advent of molecular biology because chemical carcinogens were noted to be potent mutagens as well [1]. Hereditary cancer syndromes provided further evidence of a genetic basis for carcinogenesis [2].
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Unraveling the Function of the Retinoblastoma Gene

1993
Publisher Summary Retinoblastoma is a childhood ocular tumor that can be either heritable or nonheritable. The cellular origin of retinoblastoma is a precursor of the neuroepithelial cells of the developing retina. The disease is correlated with inactivation of both alleles of a gene, RB1 , which is located on chromosome 13 band q14.2.
E, Zacksenhaus, R, Bremner, Z, Jiang, R M, Gill, M, Muncaster, M, Sopta, R A, Phillips, B L, Gallie   +7 more
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Human Retinoblastoma Susceptibility Gene

1990
It is clear that the RB-deficient tumor cells lost their tumorigenicity in nude mice after regaining the RB gene expression. However, the mechanism of tumor suppression by the RB gene is still unknown. More studies on the biological activities of RB protein, pp110RB, are necessary to answer this question.
C C, Lai, W H, Lee
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Studies on the human retinoblastoma susceptibility gene

Journal of Cellular Biochemistry, 1988
AbstractThe retinoblastoma susceptibility (RB) gene is unique among other cloned cancer genes because its causal role in a human cancer, retinoblastoma, was established by classical genetic methods before its isolation. Earlier hypotheses and experimental data suggested that inactivation of a gene in chromosome band 13q14 resulted in retinoblastoma ...
W H, Lee, R, Bookstein, E Y, Lee
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