Results 181 to 190 of about 40,097 (234)

Longitudinal analysis of retinal cell state transitions in RB1-deficient retinal organoids reveals the nascent cone precursors are the earliest cell-origin of human retinoblastoma. [PDF]

Cell Death Dis
Ye K, Wang Y, Xu P, Xie B, Wu S, Zhang W, Gao G, Zheng D, Song X, Zhang S, Guo F, Li Y, Liu Y, Wang J, Sui R, Zhong X.   +15 more
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Synergistic Anticancer Effects of Resveratrol and Carboplatin in Y79 Retinoblastoma Cells: Mechanistic Insights into Apoptosis, G2/M Arrest, and ROS-Dependent Mitochondrial Dysfunction. [PDF]

Int J Mol Sci
Maçin A, Duman E, Özdemir İ, Tuncer MC.   +3 more
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Synergistic Antitumor Effects of Rosmarinic Acid and Cisplatin in Retinoblastoma: Evidence from 2D and 3D Tumor Models. [PDF]

Biomedicines
Duman E, Maçin A, Özdemir İ, Öztürk Ş, Tuncer MC.   +4 more
europepmc   +1 more source

Human Retinal Organoid Modeling Defines Developmental Window and Therapeutic Vulnerabilities in MYCN-Amplified Retinoblastoma. [PDF]

Int J Mol Sci
Park J, Cui G, Hong J, Jeong H, Han M, Choi MS, Lim JA, Han S, Lee CS, Kim M, Kim S, Lee J, Byeon SH.   +12 more
europepmc   +1 more source

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Hypermethylation in the retinoblastoma gene is associated with unilateral, sporadic retinoblastoma

Cancer Genetics and Cytogenetics, 1997
We previously reported 9 unilateral, sporadic retinoblastomas with hypermethylation in the 5' region of the RB gene, and we found that CpG methylation in the RB promoter inhibits the binding of the retinoblastoma binding factor 1 (RBF-1) and the activating transcription factor (ATF)-like factors, thereby resulting in a considerable reduction in RB ...
N, Ohtani-Fujita, T P, Dryja, J M, Rapaport, T, Fujita, S, Matsumura, K, Ozasa, Y, Watanabe, K, Hayashi, K, Maeda, S, Kinoshita, T, Matsumura, Y, Ohnishi, Y, Hotta, R, Takahashi, M V, Kato, K, Ishizaki, M S, Sasaki, B, Horsthemke, K, Minoda, T, Sakai   +19 more
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Differential expression of genes in retinoblastoma

Clinica Chimica Acta, 2011
Retinoblastoma is a pediatric eye tumor that serves as a paradigm for understanding the genetic basis of cancer. Mutations and/or epigenetic alterations inactivating both alleles of the retinoblastoma gene (RB) are associated with retinoblastoma. There are many other genes which express differentially in the preneoplastic retinal cells after RB loss ...
Parul, Saxena, Jasbir, Kaur
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Retinoma, Retinocytoma, and the Retinoblastoma Gene

Archives of Ophthalmology, 1983
In this issue of theArchives, Margo et al (p 1519) described the pathologic findings in six cases of a "benign retinal tumor" that occurred in five children. Tumor samples from these patients were studied by light and electron microscopy and tested for S-100 protein, a glial-cell tissue marker.
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Gene Carrier Detection in Retinoblastoma

Ophthalmology, 1980
Although the presence of the retinoblastoma (RB) gene is usually made obvious by bilateral RB tumors, unaffected relatives of RB patients and unilateral RB patients may also carry the gene. Patients with 13q14 deletion have RB, and segregation of RB with markers (Q-banding and Esterase D) on chromosome 13 can be studied in some two-generation RB ...
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Retinoblastoma gene in malignancy

1996
The central importance of genetic damage in the development of tumors was suspected prior to the advent of molecular biology because chemical carcinogens were noted to be potent mutagens as well [1]. Hereditary cancer syndromes provided further evidence of a genetic basis for carcinogenesis [2].
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Unraveling the Function of the Retinoblastoma Gene

1993
Publisher Summary Retinoblastoma is a childhood ocular tumor that can be either heritable or nonheritable. The cellular origin of retinoblastoma is a precursor of the neuroepithelial cells of the developing retina. The disease is correlated with inactivation of both alleles of a gene, RB1 , which is located on chromosome 13 band q14.2.
E, Zacksenhaus, R, Bremner, Z, Jiang, R M, Gill, M, Muncaster, M, Sopta, R A, Phillips, B L, Gallie   +7 more
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