Results 11 to 20 of about 342,858 (267)

UBE2QL1 is Disrupted by a Constitutional Translocation Associated with Renal Tumor Predisposition and is a Novel Candidate Renal Tumor Suppressor Gene [PDF]

, 2013
Investigation of rare familial forms of renal cell carcinoma (RCC) has led to the identification of genes such as VHL and MET that are also implicated in the pathogenesis of sporadic RCC. In order to identify a novel candidate renal tumor suppressor gene,
Hodgson, S, Morris, Mark R., Turnell, Andrew S., Woodward, ER, Prigmore, Elena, Woodward, Emma R.; id_orcid, Wake, NC, Wake, Naomi C., Gribble, Susan M., Ricketts, Christopher J., Skytte, AB, Brown, Michael, Banks, RE, Morris, MR, Prigmore, E, Maher, ER, Woodward, Emma R., Clarke, Noel, Hodgson, Shirley, Skytte, Anne-bine, Ricketts, CJ, Turnell, AS, Brown, Michael; id_orcid, Maher, Eamonn R., Clarke, N, Banks, Rosamonde E., Gribble, SM, Brown, M, Skytte, Anne Bine   +28 more
core   +1 more source

Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter [PDF]

, 2010
The cytokine TGF-beta acts as a tumor suppressor in normal epithelial cells and during the early stages of tumorigenesis. During malignant progression, cancer cells can switch their response to TGF-beta and use this cytokine as a potent oncogenic factor;
Hiller, L, Monteverde, M, Louise Hiller, Shah, Reshma, Kalna, G., Karin A. Oien, Jonathan A. Cooper, Maurer, M.E., O'Brien, Darren I, Jelena Mann, Oien, KA, Frame, MC, Frame, Margaret C., David C. K. Chu, Crook, T., Chu, David C K, Lo Nigro, Cristiana, Lattanzio, L., Orange, Clare, Spender, Lindsay C., Chu, D.C.K., Thurlow, JK, Thurlow, Johanna K., Shah, R, Linda J. Nicholson, Syed, Nelofer, Harris, Adrian L, Orange, Cl., O'Brien, Darren I., Maurer, Meghan E., Shah, R., Nicholson, LJ, Hiller, Louise, Cooper, J.A., Inman, GJ, Monteverde, M., O'Brien, DI, West, CM, Mann, Jelena, Inman, Gareth J., Harris, AL., Syed, N, Cristiana Lo Nigro, Buffa, FM, Darren I. O’Brien, West, CML, Gasco, Milena, Smith, P, Crook, Tim, Monteverde, Martino, Meghan E. Maurer, Buffa, Francesca M., Kalna, Gabriela, O Brien, DI, Patridge, Max, Hannigan, A., Patridge, M., Paul Smith, Francesca M. Buffa, Cooper, Jonathan A, Mann, J, Oien, Karin A, Crook, T, Spender, Lindsay C.; id_orcid, Reshma Shah, Smith, Paul J., Lattanzio, L, Orange, C, Catharine M. L. West, Kalna, G, Cooper, JA, Max Patridge, Smith, Paul, Johanna K. Thurlow, Margaret C. Frame, Nicholson, Linda J., O'Brien, D.I., Spender, LC, and Gareth J. Inman, Buffa, Francesca M, O'Brien, Darren I., West, Catharine M L, Herrera, Blanca, Gasco, M., Adèle Hannigan, Smith, P., Frame, MC., Milena Gasco, Lo Nigro, C., Inman, Gareth J, Herrera, B, Oien, K.A., Frame, Margaret C, Laura Lattanzio, Gabriela Kalna, West, Catharine M. L., Nicholson, Linda J, Tim Crook, West, C.M.L., Nelofer Syed, Chu, DCK, Blanca Herrera, West, Catharine M L; id_orcid, Hannigan, Adèle, Thurlow, Johanna K, Chu, DC, Mann, J., Spender, Lindsay C, Gasco, M, Clare Orange, Martino Monteverde, Patridge, M, Buffa, F.M., Maurer, Meghan E, David C.K. Chu, Chu, David C. K., Nicholson, L.J., Harris, AL, Spender, L.C., Lindsay C. Spender, Catharine M.L. West, Herrera, B., Hannigan, A, Maurer, ME, Cooper, Jonathan A., Oien, Karin A., Lo Nigro, C, Adrian L. Harris, Inman, G.J., Gareth J. Inman, Harris, Adrian L., Thurlow, J.K., Syed, N., Lattanzio, Laura   +133 more
core   +1 more source

Tumor Suppressors Having Oncogenic Functions: The Double Agents

Cells, 2020
Cancer progression involves multiple genetic and epigenetic events, which involve gain-of-functions of oncogenes and loss-of-functions of tumor suppressor genes. Classical tumor suppressor genes are recessive in nature, anti-proliferative, and frequently
Neerajana Datta, Shrabastee Chakraborty, Malini Basu, Mrinal K. Ghosh   +3 more
doaj   +1 more source

Combined analysis and validation for DNA methylation and gene expression profiles associated with prostate cancer

Cancer Cell International, 2019
Background Prostate cancer (PCa) is a malignancy cause of cancer deaths and frequently diagnosed in male. This study aimed to identify tumor suppressor genes, hub genes and their pathways by combined bioinformatics analysis.
Yanqiu Tong, Yang Song, Shixiong Deng
doaj   +1 more source

Transposon delivery for CRISPR-based loss-of-function screen in mice identifies NF2 as a cooperating gene involved with the canonical WNT signaling molecular class of hepatocellular carcinoma

Heliyon, 2023
Various molecular subclasses of hepatocellular carcinoma (HCC) exists, with many novel cooperating oncogenes and tumor suppressor genes involved in its tumorigenesis. The emerging importance of WNT signaling in HCC has been established.
Vincent W. Keng, Amy P. Chiu, Jeffrey C. To, Xiao-Xiao Li, Michael A. Linden, Khalid Amin, Branden S. Moriarity, Kosuke Yusa   +7 more
doaj   +1 more source

Transcriptional responses of tumor cell lines to interferon-alpha [PDF]

, 2013
Interferon is an antiviral and antiproliferative cytokine therapeutically applied to treat hepatitis infection and cancer expansion. The beneficial effects of interferon-alpha are dependent on efficient signaling by activation of defined JAK-STAT pathway
Siegrist, Fredy
core   +1 more source

BECN1 and BRCA1 Deficiency Sensitizes Ovarian Cancer to Platinum Therapy and Confers Better Prognosis

Biomedicines, 2021
Background: BRCA1, BECN1 and TP53 are three tumor suppressor genes located on chromosome 17 and frequently found deleted, silenced, or mutated in many cancers.
Amreen Salwa, Alessandra Ferraresi, Menaka Chinthakindi, Letizia Vallino, Chiara Vidoni, Danny N. Dhanasekaran, Ciro Isidoro   +6 more
doaj   +1 more source

Promoter Hypermethylation of Tumor Suppressor Genes Located on Short Arm of the Chromosome 3 as Potential Biomarker for the Diagnosis of Nasopharyngeal Carcinoma

Diagnostics, 2021
DNA methylation, the most common epigenetic alteration, has been proven to play important roles in nasopharyngeal carcinoma (NPC). Numerous tumor suppressor genes located on the chromosome 3p, particularly in the region of 3p21, are frequently methylated
Thuan Duc Lao, Toan Ngoc Nguyen, Thuy Ai Huyen Le   +2 more
doaj   +1 more source

Breast Cancer Adjuvant Radiotherapy in BRCA1/2, TP53, ATM Genes Mutations: Are There Solved Issues?

Breast Cancer: Targets and Therapy, 2021
Grazia Lazzari,1 Giuseppe Buono,2 Benedetto Zannino,2 Giovanni Silvano1 1Radiation Oncology Unit, San Giuseppe Moscati Hospital, Taranto, 74100, Italy; 2Medical Oncology Unit, San Rocco Hospital, Sessa Aurunca, Caserta, 81037, ItalyCorrespondence: Grazia
Lazzari G, Buono G, Zannino B, Silvano G
doaj  

Deregulated Metabolic Pathways in Ovarian Cancer: Cause and Consequence

Metabolites, 2023
Ovarian cancers are tumors that originate from the different cells of the ovary and account for almost 4% of all the cancers in women globally. More than 30 types of tumors have been identified based on the cellular origins.
Roopak Murali, Vaishnavi Balasubramaniam, Satish Srinivas, Sandhya Sundaram, Ganesh Venkatraman, Sudha Warrier, Arun Dharmarajan, Rajesh Kumar Gandhirajan   +7 more
doaj   +1 more source