Results 21 to 30 of about 342,858 (267)

Prevention of Tumor Growth and Dissemination by In Situ Vaccination with Mitochondria‐Targeted Atovaquone

Advanced Science, 2022
Atovaquone, an FDA‐approved drug for malaria, is known to inhibit mitochondrial electron transport. A recently synthesized mitochondria‐targeted atovaquone increased mitochondrial accumulation and antitumor activity in vitro. Using an in situ vaccination
Mofei Huang, Donghai Xiong, Jing Pan, Qi Zhang, Yian Wang, Charles R. Myers, Bryon D. Johnson, Micael Hardy, Balaraman Kalyanaraman, Ming You   +9 more
doaj   +1 more source

Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma

Liver Research, 2021
Hepatocellular carcinoma (HCC) is a very deadly disease. HCC initiation and progression involve multiple genetic events, including the activation of proto-oncogenes and disruption of the function of specific tumor suppressor genes.
Fang Wang, Peter Breslin S J, Wei Qiu
doaj   +1 more source

Neural stem cells in Drosophila : molecular genetic mechanisms underlying normal neural proliferation and abnormal brain tumor formation [PDF]

, 2012
Neural stem cells in Drosophila are currently one of the best model systems for understanding stem cell biology during normal development and during abnormal development of stem cell-derived brain tumors.
Heinrich Reichert, Reichert, Heinrich, Saini, Nidhi, Nidhi Saini   +3 more
core   +1 more source

The N-Terminal Region of the Transcription Factor E2F1 Contains a Novel Transactivation Domain and Recruits General Transcription Factor GTF2H2

Biomolecules
The transcription factor E2F1 is the principal target of the tumor suppressor pRB. E2F1 promotes cell proliferation by activating growth-promoting genes upon growth stimulation.
Lin Zhao, Rinka Nakajima, Yaxuan Zhou, Mashiro Shirasawa, Mariana Fikriyanti, Yuki Kamiya, Hiroyuki Toh, Hideyuki Komori, Ritsuko Iwanaga, Andrew P. Bradford, Hideo Nishitani, Kenta Kurayoshi, Keigo Araki, Kiyoshi Ohtani   +13 more
doaj   +1 more source

The Effect of 5-Aza-2′-Deoxycytidine in Combination to and in Comparison with Vorinostat on DNA Methyltransferases, Histone Deacetylase 1, Glutathione S-Transferase 1 and Suppressor of Cytokine Signaling 1 Genes Expression, Cell Growth Inhibition and Apop

International Journal of Hematology-Oncology and Stem Cell Research, 2020
Background: Aberrant methylation and histone deacetylation of tumor suppressor genes (TSGs) are the most epigenetic alterations involving in tumorigenesis.
Masumeh Sanaei, Fraidoon Kavoosi, Zahra Esmi   +2 more
doaj   +1 more source

Tumor suppressor genes in myeloid differentiation and leukemogenesis

, 2009
Tumor suppressor genes, such as p53, RB, the INK4-ARF family and PML, suppress malignant transformation by regulating cell cycle progression, ensuring the fidelity of DNA replication and chromosomal segregation, or by inducing apoptosis in response to ...
Britschgi, Christian, Fey, Martin F
core   +1 more source

Breast Cancer Stem Cells and Tumor Suppressor Genes

Journal of the Formosan Medical Association, 2008
Studies of breast cancer stem cells are in their infancy and many fundamental questions have yet to be fully addressed. The molecular distinction between normal and cancerous breast stem cells is not clear.
Wendy W. Hwang-Verslues, King-Jen Chang, Eva Y.-H.P. Lee, Wen-Hwa Lee   +3 more
doaj   +1 more source

Tumor-suppressor-oncogene-scores (TSOS).

, 2018
(a) Enrichment analysis using expression derived tumor-suppressor-oncogene-score (TSOS) in human tumors microarray and TCGA/GTEx RNAseq datasets for the whole candidate ortholog gene set (n = 619 and n = 637 respectively) in 1 million random samplings ...
Helena E. Richardson (434920), Shane J. F. Cronin (5859743), Lee Willoughby (5859722), Patrick O. Humbert (136871), Andreas Wernitznig (731157), Constantine S. Mitsiades (348466), Sofya Golenkina (5859731), Susanne Gruber (5859737), Ricardo Matos de Simoes (5859725), G. Gregory Neely (113800), Jan Manent (5859719), Elisabeth Eva Kanitz (368265), Kaylene J. Simpson (146322), Josef M. Penninger (113854), Tamara Zoranovic (5859716), John E. La Marca (5859728), Belinda Angjeli (5859740), Xia Cuiping (5859734)   +17 more
core   +1 more source

Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis [PDF]

, 2002
Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest group of malignant tumors. Colorectal cancer is one of the most common neoplastic diseases in Western countries and one of the leading causes of ...
Bommer, G., Göke, Burkhard, Göke, B., Kolligs, Frank T, Bommer, Guido, Kolligs, F. T.   +5 more
core   +1 more source

Effects of DNMT1 silencing on malignant phenotype and methylated gene expression in cervical cancer cells

Journal of Experimental & Clinical Cancer Research, 2011
Background DNA methylation has been widely used in classification, early diagnosis, therapy and prediction of metastasis as well as recurrence of cervical cancer.
Li Ti-yuan, Zhou Shu-yan, Sun Ye-hong, Chen Fu-qiang, Zhang Yi, Chen Rui   +5 more
doaj   +1 more source