Results 61 to 70 of about 485,737 (297)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Mutant p53 and ETS2, a tale of reciprocity

Frontiers in Oncology, 2016
TP53 is one of the most frequently inactivated tumor suppressor genes in human cancer. However, unlike other tumor suppressor genes whose expression is lost, TP53 is usually inactivated as a result of a single nucleotide change within the coding region.
Luis Alfonso Martinez
doaj   +1 more source

Cancer-Associated circRNA–miRNA–mRNA Regulatory Networks: A Meta-Analysis

Frontiers in Molecular Biosciences, 2021
Recent advances in sequencing technologies and the discovery of non-coding RNAs (ncRNAs) have provided new insights in the molecular pathogenesis of cancers.
Shaheerah Khan, Shaheerah Khan, Atimukta Jha, Atimukta Jha, Amaresh C. Panda, Anshuman Dixit   +5 more
doaj   +1 more source

Hypermethylated gene ANKDD1A is a candidate tumor suppressor that interacts with FIH1 and decreases HIF1α stability to inhibit cell autophagy in the glioblastoma multiforme hypoxia microenvironment. [PDF]

, 2019
Ectopic epigenetic mechanisms play important roles in facilitating tumorigenesis. Here, we first demonstrated that ANKDD1A is a functional tumor suppressor gene, especially in the hypoxia microenvironment.
Fan, Li, Feng, Jianbo, Fu, Haijuan, Li, Guiyuan, Li, Peiyao, Liu, Changhong, Liu, Qiang, Liu, Qing, Ren, Xing, She, Xiaoling, Sun, Yingnan, Wu, Minghua, Zhang, Yan, Zhao, Chunhua   +13 more
core   +1 more source

Bone morphogenetic protein 7 sensitizes O6-methylguanine methyltransferase expressing-glioblastoma stem cells to clinically relevant dose of temozolomide. [PDF]

, 2015
BackgroundTemozolomide (TMZ) is an oral DNA-alkylating agent used for treating patients with glioblastoma. However, therapeutic benefits of TMZ can be compromised by the expression of O6-methylguanine methyltransferase (MGMT) in tumor tissue.
Bui, Yvonne, Cloughesy, Timothy F, Hong, Irene, Lai, Albert, Liau, Linda M, McBride, William H, Menjivar, Jimmy C, Nelson, Stanley F, Stream, Alexandra, Tso, Cho-Lea, Tso, Jonathan L, Yamada, Kazunari, Yang, Shuai, Yong, William H, Zhang, Yibei   +14 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Extracellular vesicles produced in B cells deliver tumor suppressor miR-335 to breast cancer cells disrupting oncogenic programming in vitro and in vivo. [PDF]

, 2018
The successful implementation of miRNA (miR) therapies in humans will ultimately rely on the use of vehicles with improved cellular delivery capability. Here we tested a new system that leverages extracellular vesicles (EVs) laden with a tumor suppressor
Almanza, Gonzalo, Carter, Hannah, Jepsen, Kristen, Rodvold, Jeffrey J, Tsui, Brian, Zanetti, Maurizio   +5 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Non-coding RNAs as therapeutic targets in cancer and its clinical application

Journal of Pharmaceutical Analysis
Cancer genomics has led to the discovery of numerous oncogenes and tumor suppressor genes that play critical roles in cancer development and progression.
Xuejiao Leng, Mengyuan Zhang, Yujing Xu, Jingjing Wang, Ning Ding, Yancheng Yu, Shanliang Sun, Weichen Dai, Xin Xue, Nianguang Li, Ye Yang, Zhihao Shi   +11 more
doaj   +1 more source

Cancer: Disease Caused by Alteration of Genes [PDF]

International Journal of Basic Science in Medicine, 2016
In normal cells when genetic defects occur, there are some sensitive mechanisms through which the defect might be repaired or apoptosis might be induced.
Manzoor Ahmad Malik, Zahra Sepehri, Zafar Amin Shah   +2 more
doaj   +1 more source