Results 101 to 110 of about 798,219 (310)

Virioplankton assemblages from challenger deep, the deepest place in the oceans

iScience, 2022
Summary: Hadal ocean biosphere, that is, the deepest part of the world’s oceans, harbors a unique microbial community, suggesting a potential uncovered co-occurring virioplankton assemblage.
Chen Gao, Yantao Liang, Yong Jiang, David Paez-Espino, Meiaoxue Han, Chengxiang Gu, Meiwen Wang, Yumei Yang, Fengjiao Liu, Qingwei Yang, Zheng Gong, Xinran Zhang, Zhixiang Luo, Hui He, Cui Guo, Hongbing Shao, Chun Zhou, Yang Shi, Yu Xin, Jinyan Xing, Xuexi Tang, Qilong Qin, Yu-Zhong Zhang, Jianfeng He, Nianzhi Jiao, Andrew McMinn, Jiwei Tian, Curtis A. Suttle, Min Wang   +28 more
doaj  

Materials promoting viral gene delivery

Biomaterials Science, 2020
This review discusses the progress in developing materials that enhance viral transduction, including polymers, peptides, lipids, nanoparticles, and small molecules.
Kübra Kaygisiz, Christopher V. Synatschke   +1 more
openaire   +5 more sources

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Comparative metagenomic analyses reveal viral-induced shifts of host metabolism towards nucleotide biosynthesis [PDF]

, 2014
BACKGROUND: Viral genomes often contain metabolic genes that were acquired from host genomes (auxiliary genes). It is assumed that these genes are fixed in viral genomes as a result of a selective force, favoring viruses that acquire specific metabolic ...
Hagay Enav, Oded Béjà, Yael Mandel-Gutfreund   +2 more
core   +2 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Genomic and biologic comparisons of cyprinid herpesvirus 3 strains [PDF]

, 2018
Cyprinid herpesvirus 3 (CyHV-3) is the archetypal fish alloherpesvirus and the etiologic agent of a lethal disease in common and koi carp. To date, the genome sequences of only four CyHV-3 isolates have been published, but no comparisons of the biologic ...
Bergmann, Sven, Boutier, Maxime, Davison, Andrew J., Dong, Chuanfu, Gao, Yuan, Lee, Pei-Yu Alison, Suárez, Nicolás M., Vanderplasschen, Alain F.C., Wilkie, Gavin S.   +8 more
core   +2 more sources

RNA interference identifies domesticated viral genes involved in assembly and trafficking of virus-derived particles in ichneumonid wasps.

PLoS Pathogens, 2019
There are many documented examples of viral genes retained in the genomes of multicellular organisms that may in some cases bring new beneficial functions to the receivers.
Ange Lorenzi, Marc Ravallec, Magali Eychenne, Véronique Jouan, Stéphanie Robin, Isabelle Darboux, Fabrice Legeai, Anne-Sophie Gosselin-Grenet, Mathieu Sicard, Don Stoltz, Anne-Nathalie Volkoff   +10 more
doaj   +1 more source

Modeling the early steps of cytoplasmic trafficking in viral infection and gene delivery [PDF]

arXiv, 2011
Gene delivery of nucleic acid to the cell nucleus is a fundamental step in gene therapy. In this review of modeling drug and gene delivery, we focus on the particular stage of plasmid DNA or virus cytoplasmic trafficking. A challenging problem is to quantify the success of this limiting stage.
arxiv  

A single-cell RNA expression map of coronavirus receptors and associated factors in developing human embryos [PDF]

arXiv, 2020
To predict if developing human embryos are permissive to coronaviruses, we analyzed publicly available single cell RNA-seq datasets of zygotes, 4-cell, 8-cell, morula, inner cell mass, epiblast, primitive endoderm and trophectoderm for the coronavirus receptors (ACE2, BSG, DPP4 and ANPEP), the Spike protein cleavage enzymes (TMPRSS2, CTSL).
arxiv