Results 101 to 110 of about 755,314 (318)

The emergence and fate of horizontally acquired genes in Escherichia coli

, 2008
Bacterial species, and even strains within species, can vary greatly in their gene contents and metabolic capabilities. We examine the evolution of this diversity by assessing the distribution and ancestry of each gene in 13 sequenced isolates of ...
Passel, M.W.J., van, Mark W J van Passel, van Passel, M.W.J., Ochman, H., Marri, P.R., Pradeep Reddy Marri, Howard Ochman   +6 more
core   +1 more source

Polyomavirus BK with rearranged noncoding control region emerge in vivo in renal transplant patients and increase viral replication and cytopathology [PDF]

, 2008
Immunosuppression is required for BK viremia and polyomavirus BK-associated nephropathy (PVAN) in kidney transplants (KTs), but the role of viral determinants is unclear.
Hirsch, Hans H., Hans H. Hirsch, Emilio Ramos, Christine H. Rinaldo, Cinthia B. Drachenberg, Funk, Georg A., Ramos, Emilio, Drachenberg, Cinthia B., Rainer Gosert, Gosert, Rainer, Adrian Egli, Georg A. Funk, Egli, Adrian, Rinaldo, Christine H.   +13 more
core   +1 more source

The accessibility of the HSV genome during productive infection can vary in different cell types and affect the outcome of infection

mBio
During productive herpes simplex virus type 1 (HSV-1) infection, the viral genome encounters a number of cellular and viral proteins, such as ICP4, which engage in processes that either attenuate or activate transcription.
Jenna M. Nosek, Sarah E. Dremel, Neal A. DeLuca   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Genes diferencialmente expressos em camarões de cultivo Litopennaeus vannamei infectados pelo vírus da Síndrome da Mancha Branca e genotipagem de isolados geográficos brasileiros do vírus [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biotecnologia, Florianópolis, 2009.O vírus da Síndrome da Mancha Branca (WSSV) é uma doença que afeta várias espécies de crustáceos ...
Müller, Isabel Cristina
core  

MosaicSolver : a tool for determining recombinants of viral genomes from pileup data [PDF]

, 2014
Viral recombination is a key evolutionary mechanism, aiding escape from host immunity, contributing to changes in tropism and possibly assisting transmission across species barriers.
Burroughs, Nigel, Fannon, Jessica, Moore, Jonathan D., Fannon, Jessica M., Ryabov, Eugene V., Wood, Graham R., Evans, David J., Burroughs, Nigel John, Wood, Graham   +8 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Viral interferon antagonists and antiviral drugs

, 2009
For this project, we developed reporter cell lines that express viral proteins with the potential to be used in cell-based screening assays to select chemical candidates for antiviral drugs.
Nobre, Rita
core  

Activation and modulation of antiviral and apoptotic genes in pigs infected with classical swine fever viruses of high, moderate or low virulence [PDF]

, 2009
The immune response to CSFV and the strategies of this virus to evade and suppress the pigs’ immune system are still poorly understood. Therefore, we investigated the transcriptional response in the tonsils, median retropharyngeal lymph node (MRLN), and ...
Hulst, M.M., Loeffen, W.L.A., Wit, A.A.C., de, A. A. C. de Wit, Mastebroek, B., S. V. M. Durand, W. L. A. Loeffen, Durand, S.V.M., L. Mastebroek, M. M. Hulst, de Wit, A.A.C.   +10 more
core   +1 more source