Results 241 to 250 of about 1,028,945 (306)

Integrated Single‐Cell and Spatial Transcriptomics Reveal Cell‐Type‐Specific Immune Regulatory Networks in Maize Responding to Southern Corn Rust

Advanced Science, EarlyView.
By integrating single‐nuclei and spatial transcriptomics, this study presents a stereoscopic landscape of maize leaf to Puccinia polysora infection. Epidermal and mesophyll cells initiate primary defenses via RLPs/RLKs and jasmonic acid signaling. Cell‐cell communication analyses further reveal the underlying the dynamics of the underlying immune ...
Qiongqiong Wang, Xinyan Sun, Yingchao Sun, Zeqiang Cheng, Zixiang Cheng, Shengbo Han, Ying Feng, Wenbo Yang, Huimin Li, Meichen Zhu, Xiaoling Wu, Jinghua Zhang, Jihua Tang, Honglian Li, Yanyong Cao, Canxing Duan, Yan Shi   +16 more
wiley   +1 more source

Transcriptional analysis of duck liver infected with duck hepatitis A virus type 1 isolate HA5. [PDF]

Front Vet Sci
Yin D, Gao Y, Guo X, Xu H, Li Y, Hu F, Yu K, Huang B, Qin Z, Yang J, Ma X.   +10 more
europepmc   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Cross-kingdom genomic variation in chicken gut microbiomes: insights from China's diverse local breeds. [PDF]

Microbiome
Zhang J, Xu L, Ge X, Zi X, Chen S, Liu C, Wang K, Zhou J, Dou T, Wong JWC, Lin Q, Kang X, Cao Z.   +12 more
europepmc   +1 more source

Cold Orthogonal Translation: A Psychrophilic Pyrrolysyl‐tRNA Synthetase Boosts Genetic Code Expansion in E. coli

Advanced Science, EarlyView.
ABSTRACT Orthogonal translation systems (OTSs) enable site‐specific incorporation of non‐canonical amino acids (ncAAs) and are central to genetic code expansion. Current engineering strategies typically rely on hyperstable aminoacyl tRNA synthetase (aaRS) scaffolds to tolerate destabilizing mutations required for substrate diversification.
Nikolaj G. Koch, Peter Goettig, Michael A. Nash, Juri Rappsilber, Nediljko Budisa   +4 more
wiley   +1 more source

Single-cell transcriptomic profiling of the splenic and peripheral immune landscape in rhesus macaques during CHIKV infection. [PDF]

J Virus Erad
Yang Y, Huang Q, Yang H, Zhou Y, Wang J, Tang C, Yu W, Wang H, Wu D, Chen H, Li B, Quan W, Shi J, Sun Q, Lu S.   +14 more
europepmc   +1 more source

Tachinid Endoparasitoid Flies do not Rely on Domesticated Viruses, Unlike Multiple Hymenopteran Lineages. [PDF]

Genome Biol Evol
Oukkal S, Guinet B, Hebert PDN, Janzen D, Hallwachs W, Fleming AJ, Charlat S, Varaldi J.   +7 more
europepmc   +1 more source

Unveiling the hidden viral biodiversity and potential ecological functions with global coral holobiont virome database. [PDF]

NPJ Biofilms Microbiomes
Wu M, Wen X, Liu S, Ngo HH, Cai Z, Zhou J.   +5 more
europepmc   +1 more source

Deciphering cassava brown streak virus infection in cassava through VPg mediated host protein interactions. [PDF]

Arch Virol
Kakkunnath SM, Bouvaine S, Kavil SP, Maruthi MN.   +3 more
europepmc   +1 more source

Extracellular vesicles from activated Vδ2 T cells inhibit viral replication and enhance adaptive antiviral immunity. [PDF]

J Transl Med
Bordoni V, Guarracino F, Marocco F, Quattrocchi L, Lorusso A, Minutolo A, Garbo S, Pellegrino M, Vinci M, Matteucci C, Pagliara D, Galaverna F, Merli P, Battistelli C, Locatelli F, Agrati C.   +15 more
europepmc   +1 more source