Results 251 to 260 of about 755,314 (318)

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

open access: yesAdvanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng   +8 more
wiley   +1 more source

Distinct roles of dopamine receptors in HIV latency reversal in a myeloid cell model. [PDF]

open access: yesFront Immunol
Basova LV   +7 more
europepmc   +1 more source

An entropy-based framework for genomic variability analysis: A South American case study of human papillomavirus. [PDF]

open access: yesPLoS One
López Leal A   +5 more
europepmc   +1 more source

EZH2 enhances PCV2 replication through inhibition of MMP1 and MMP12 transcription activity. [PDF]

open access: yesVet Res
Shan Y   +8 more
europepmc   +1 more source

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