Results 281 to 290 of about 798,219 (310)
Some of the next articles are maybe not open access.
Annals of the New York Academy of Sciences, 2003
Abstract: Epigenetics represents a new frontier in cancer research. Methylation is the best studied of the epigenetic mechanisms that regulate gene expression. Regulation of gene expression by means of methylation has been reported for tumor suppressor genes, oncogenes, viral promoters, and age‐related genes.
openaire +2 more sources
Abstract: Epigenetics represents a new frontier in cancer research. Methylation is the best studied of the epigenetic mechanisms that regulate gene expression. Regulation of gene expression by means of methylation has been reported for tumor suppressor genes, oncogenes, viral promoters, and age‐related genes.
openaire +2 more sources
Polymers for viral gene delivery
Expert Opinion on Drug Delivery, 2008The development of viral vectors capable of providing efficient gene transfer in diseased tissues without causing any pathogenic effects is pivotal for overcoming the many challenges facing gene therapy.Immune responses against viral vectors, inadequate gene expression and inefficient targeting to specific cells in vivo are some of the major problems ...
Phuong Truc T. Pham, Chun Wang
openaire +3 more sources
Annual Review of Microbiology, 1995
The use of DNA as a drug is both appealing and simple in concept. Indeed in many instances the feasibility of such an approach has been established using model systems. In practical terms, however, the delivery of DNA to human tissues presents a wide variety of problems that differ with each potential therapeutic application. In this review, the design,
openaire +3 more sources
The use of DNA as a drug is both appealing and simple in concept. Indeed in many instances the feasibility of such an approach has been established using model systems. In practical terms, however, the delivery of DNA to human tissues presents a wide variety of problems that differ with each potential therapeutic application. In this review, the design,
openaire +3 more sources
Molecular Medicine Today, 1995
Gene therapy is a medical/surgical intervention currently being developed, in which genes are introduced into cells in order to treat or cure a wide variety of human diseases. The field has evolved over the past four decades, with most experimental gene-therapy studies based on the use of viruses to deliver the genes of therapeutic interest.
Douglas A. Treco, Richard F. Selden
openaire +3 more sources
Gene therapy is a medical/surgical intervention currently being developed, in which genes are introduced into cells in order to treat or cure a wide variety of human diseases. The field has evolved over the past four decades, with most experimental gene-therapy studies based on the use of viruses to deliver the genes of therapeutic interest.
Douglas A. Treco, Richard F. Selden
openaire +3 more sources
Gene therapy for viral hepatitis
Expert Opinion on Biological Therapy, 2006Hepatitis B and C infections are two of the most prevalent viral diseases in the world. Existing therapies against chronic viral hepatitis are far from satisfactory due to low response rates, undesirable side effects and selection of resistant viral strains. Therefore, new therapeutic approaches are urgently needed.
Astrid Pañeda +5 more
openaire +3 more sources
Viral Gene Delivery in Chondrocytes
2022Viral gene transfer, known as transduction, is a powerful research tool for studying the biology of chondrocytes in novel ways and also a technology enabling the use of gene therapy for regenerating cartilage and treating diseases that affect cartilage, such as osteoarthritis.
Christopher V, Nagelli +2 more
openaire +2 more sources
2019
In the previous three chapters we’ve covered the impact our genetics can have on our health. In this final chapter we reverse this and look at the exciting field of gene therapy. In the Viral Gene Therapy simulation, you will learn about the use of modified viruses and how we can manipulate their genetic code to fix mutations inside our own bodies ...
Philip Wismer +4 more
openaire +2 more sources
In the previous three chapters we’ve covered the impact our genetics can have on our health. In this final chapter we reverse this and look at the exciting field of gene therapy. In the Viral Gene Therapy simulation, you will learn about the use of modified viruses and how we can manipulate their genetic code to fix mutations inside our own bodies ...
Philip Wismer +4 more
openaire +2 more sources
Viral Vectors for Gene Transfer
Current Protocols in Mouse Biology, 2018AbstractViral vectors are a promising tool for effective delivery of genetic material into cells. They take advantage of the natural ability of a virus to deliver a genetic payload into cells while being genetically modified such that their ability to replicate is crippled or removed. Here, an updated overview of routinely used viral vectors, including
Yong Hong Chen +3 more
openaire +3 more sources
2007
Virus-infection of mammalian cells causes transcriptional induction of many cellular genes, collectively called as "viral stress-inducible genes." The proteins encoded by these genes are essential to maintain cell-virus homeostasis, which is required for both virus replication and host survival.
Gregory A. Peters, Ganes C. Sen
openaire +3 more sources
Virus-infection of mammalian cells causes transcriptional induction of many cellular genes, collectively called as "viral stress-inducible genes." The proteins encoded by these genes are essential to maintain cell-virus homeostasis, which is required for both virus replication and host survival.
Gregory A. Peters, Ganes C. Sen
openaire +3 more sources
Evolution of C-type viral genes: inheritance of exogenously acquired viral genes
Nature, 1974Genes related to the nucleic acid of an endogenous domestic cat C-type virus (RD114) are found in the cellular DNA of anthropoid primates while many members of the cat family Felidae lack these sequences. Endogenous viruses from primates are thus concluded to have infected and become part of the germ line of an evolutionary distant group, the ancestors
Raoul E. Benveniste, George J. Todaro
openaire +3 more sources