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Viral Vectors for Gene Transfer
Current Protocols in Mouse Biology, 2018AbstractViral vectors are a promising tool for effective delivery of genetic material into cells. They take advantage of the natural ability of a virus to deliver a genetic payload into cells while being genetically modified such that their ability to replicate is crippled or removed. Here, an updated overview of routinely used viral vectors, including
Yong Hong, Chen +2 more
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1997
In 1914, Allard1 noted that challenging certain tobacco species with sap from a mosaic diseased plant resulted in a “destructive rot” at the point of inoculation. This necrotic response in many respects resembled what Stakman,2 in 1915, termed the hypersensitive reaction (HR) in particular oat varieties upon inoculation with Puccinia.
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In 1914, Allard1 noted that challenging certain tobacco species with sap from a mosaic diseased plant resulted in a “destructive rot” at the point of inoculation. This necrotic response in many respects resembled what Stakman,2 in 1915, termed the hypersensitive reaction (HR) in particular oat varieties upon inoculation with Puccinia.
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Evolution of C-type viral genes: inheritance of exogenously acquired viral genes
Nature, 1974Genes related to the nucleic acid of an endogenous domestic cat C-type virus (RD114) are found in the cellular DNA of anthropoid primates while many members of the cat family Felidae lack these sequences. Endogenous viruses from primates are thus concluded to have infected and become part of the germ line of an evolutionary distant group, the ancestors
R E, Benveniste, G J, Todaro
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2004
Somatic gene therapy aims at increasing the expression of deficient or protective factors, or at the suppression of deleterious factors. This goal will probably be achieved best by the use of viral vectors. Currently, vectors are being optimised with respect to transduction properties, levels of transgene expression, and reduction of toxicity and ...
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Somatic gene therapy aims at increasing the expression of deficient or protective factors, or at the suppression of deleterious factors. This goal will probably be achieved best by the use of viral vectors. Currently, vectors are being optimised with respect to transduction properties, levels of transgene expression, and reduction of toxicity and ...
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Molecular identification of diabetogenic viral gene
Diabetes, 1989The best evidence that viruses have a causative role in the pathogenesis of insulin-dependent diabetes mellitus comes from experiments in mice infected with encephalomyocarditis (EMC) virus. When SJL/J male mice were inoculated with a highly diabetogenic EMC-D virus, diabetes developed in 95% of the animals.
Y S, Bae, H M, Eun, J W, Yoon
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SARS-CoV-2 viral load and shedding kinetics
Nature Reviews Microbiology, 2022Olha Puhach +2 more
exaly
Manufacturing of Viral Gene Therapies
International Ophthalmology Clinics, 2021G Anthony, Ramirez, Mehdi, Gasmi
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Non-viral is superior to viral gene delivery
Journal of Controlled Release, 2007Shyh-Dar, Li, Leaf, Huang
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