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Gene Therapy with Viral Vectors
Annual Review of Pharmacology and Toxicology, 2003A key factor in the success of gene therapy is the development of gene delivery systems that are capable of efficient gene transfer in a broad variety of tissues, without causing any pathogenic effect. Currently, viral vectors based on many different viruses have been developed, and their performance and pathogenicity has been evaluated in animal ...
Neeltje A, Kootstra, Inder M, Verma
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Viral Vectors for Gene Transfer
Current Protocols in Mouse Biology, 2018AbstractViral vectors are a promising tool for effective delivery of genetic material into cells. They take advantage of the natural ability of a virus to deliver a genetic payload into cells while being genetically modified such that their ability to replicate is crippled or removed. Here, an updated overview of routinely used viral vectors, including
Yong Hong, Chen +2 more
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Molecular Medicine Today, 1995
Gene therapy is a medical/surgical intervention currently being developed, in which genes are introduced into cells in order to treat or cure a wide variety of human diseases. The field has evolved over the past four decades, with most experimental gene-therapy studies based on the use of viruses to deliver the genes of therapeutic interest.
D A, Treco, R F, Selden
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Gene therapy is a medical/surgical intervention currently being developed, in which genes are introduced into cells in order to treat or cure a wide variety of human diseases. The field has evolved over the past four decades, with most experimental gene-therapy studies based on the use of viruses to deliver the genes of therapeutic interest.
D A, Treco, R F, Selden
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2007
Virus-infection of mammalian cells causes transcriptional induction of many cellular genes, collectively called as "viral stress-inducible genes." The proteins encoded by these genes are essential to maintain cell-virus homeostasis, which is required for both virus replication and host survival.
Ganes C, Sen, Gregory A, Peters
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Virus-infection of mammalian cells causes transcriptional induction of many cellular genes, collectively called as "viral stress-inducible genes." The proteins encoded by these genes are essential to maintain cell-virus homeostasis, which is required for both virus replication and host survival.
Ganes C, Sen, Gregory A, Peters
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Current Opinion in Biotechnology, 1994
Non-viral gene therapies are currently under development that employ drug-delivery methods for targeting genes to selected cells in the body, where they express therapeutic gene products. Various methods have been described for non-viral gene therapy, ranging from the direct intramuscular injection of purified DNA to the systemic administration of ...
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Non-viral gene therapies are currently under development that employ drug-delivery methods for targeting genes to selected cells in the body, where they express therapeutic gene products. Various methods have been described for non-viral gene therapy, ranging from the direct intramuscular injection of purified DNA to the systemic administration of ...
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Evolution of C-type viral genes: inheritance of exogenously acquired viral genes
Nature, 1974Genes related to the nucleic acid of an endogenous domestic cat C-type virus (RD114) are found in the cellular DNA of anthropoid primates while many members of the cat family Felidae lack these sequences. Endogenous viruses from primates are thus concluded to have infected and become part of the germ line of an evolutionary distant group, the ancestors
R E, Benveniste, G J, Todaro
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1983
Endogenous viruses are defined as germline genes that code for the components of a retrovirus. These genes are present in all cells of all tissues of an animal and are inherited by progeny in a Mendelian manner. Two general methods have been used to detect the presence of endogenous viral sequences in DNA of a given species.
U G, Rovigatti, S M, Astrin
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Endogenous viruses are defined as germline genes that code for the components of a retrovirus. These genes are present in all cells of all tissues of an animal and are inherited by progeny in a Mendelian manner. Two general methods have been used to detect the presence of endogenous viral sequences in DNA of a given species.
U G, Rovigatti, S M, Astrin
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Molecular identification of diabetogenic viral gene
Diabetes, 1989The best evidence that viruses have a causative role in the pathogenesis of insulin-dependent diabetes mellitus comes from experiments in mice infected with encephalomyocarditis (EMC) virus. When SJL/J male mice were inoculated with a highly diabetogenic EMC-D virus, diabetes developed in 95% of the animals.
Y S, Bae, H M, Eun, J W, Yoon
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2018
Although viral vectors comprise the majority of gene delivery vectors, their various safety, production, and other practical concerns have left a research gap to be addressed. The non-viral vector space encompasses a growing variety of physical and chemical methods capable of gene delivery into the nuclei of target cells.
Chi Hong, Sum +3 more
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Although viral vectors comprise the majority of gene delivery vectors, their various safety, production, and other practical concerns have left a research gap to be addressed. The non-viral vector space encompasses a growing variety of physical and chemical methods capable of gene delivery into the nuclei of target cells.
Chi Hong, Sum +3 more
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FORMAL MODELLING OF VIRAL GENE COMPRESSION
International Journal of Foundations of Computer Science, 2005The study of viruses in molecular genetics, as biological entities with extremely small genomes, and in medicine, as pathogens, represents an important area of inquiry with significant potential for improving scientific knowledge in both domains. One of the most fascinating genetic adaptations of viruses is the ability to compress their own genomes ...
Mark Daley, Ian McQuillan
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