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Viral and Non-viral Nanoparticles for Gene Therapeutics
2022The recent accomplishment of the human genome and DNA discovery has led to the diagnosis of many diseases caused by imperfections in genes. These diseases involve gross disturbances in the number or arrangement of a person's chromosomes. Hence, gene therapy has become a promising new therapy for the treatment of somatic diseases, for example, malignant
Hassan Elsana, Amal Ali Elkordy
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2019
In the previous three chapters we’ve covered the impact our genetics can have on our health. In this final chapter we reverse this and look at the exciting field of gene therapy. In the Viral Gene Therapy simulation, you will learn about the use of modified viruses and how we can manipulate their genetic code to fix mutations inside our own bodies ...
Aaron Gardner +4 more
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In the previous three chapters we’ve covered the impact our genetics can have on our health. In this final chapter we reverse this and look at the exciting field of gene therapy. In the Viral Gene Therapy simulation, you will learn about the use of modified viruses and how we can manipulate their genetic code to fix mutations inside our own bodies ...
Aaron Gardner +4 more
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Manufacturing of Viral Gene Therapies
International Ophthalmology Clinics, 2021G Anthony, Ramirez, Mehdi, Gasmi
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Non-viral is superior to viral gene delivery
Journal of Controlled Release, 2007Shyh-Dar, Li, Leaf, Huang
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Non-viral gene delivery systems
Current Opinion in Biotechnology, 2002Non-viral gene delivery systems have the potential to create viable pharmaceuticals from nucleic acids. These DNA delivery systems contain lipids and/or cationic polymers. In order for these systems to be developed into commercial products, several barriers must be overcome. These include obstacles in manufacturing, formulation and stability.
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1997
In 1914, Allard1 noted that challenging certain tobacco species with sap from a mosaic diseased plant resulted in a “destructive rot” at the point of inoculation. This necrotic response in many respects resembled what Stakman,2 in 1915, termed the hypersensitive reaction (HR) in particular oat varieties upon inoculation with Puccinia.
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In 1914, Allard1 noted that challenging certain tobacco species with sap from a mosaic diseased plant resulted in a “destructive rot” at the point of inoculation. This necrotic response in many respects resembled what Stakman,2 in 1915, termed the hypersensitive reaction (HR) in particular oat varieties upon inoculation with Puccinia.
openaire +1 more source
2004
Somatic gene therapy aims at increasing the expression of deficient or protective factors, or at the suppression of deleterious factors. This goal will probably be achieved best by the use of viral vectors. Currently, vectors are being optimised with respect to transduction properties, levels of transgene expression, and reduction of toxicity and ...
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Somatic gene therapy aims at increasing the expression of deficient or protective factors, or at the suppression of deleterious factors. This goal will probably be achieved best by the use of viral vectors. Currently, vectors are being optimised with respect to transduction properties, levels of transgene expression, and reduction of toxicity and ...
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Non-viral and viral vectors for gene therapy.
Cellular and molecular biology (Noisy-le-Grand, France), 2006Human gene therapy can be defined as the delivery of genetic material into a patient's cells with a therapeutic aim. The success or failure of gene therapy depends on the development and efficiency of the transfection of viral and non-viral vectors. Viral vectors typically offer higher transduction efficiency and long-term gene expression, but may be ...
H, Boulaiz +4 more
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SARS-CoV-2 viral load and shedding kinetics
Nature Reviews Microbiology, 2022Olha Puhach +2 more
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