Results 61 to 70 of about 755,314 (318)

Viral perturbations of host networks reflect disease etiology.

PLoS Computational Biology, 2012
Many human diseases, arising from mutations of disease susceptibility genes (genetic diseases), are also associated with viral infections (virally implicated diseases), either in a directly causal manner or by indirect associations.
Natali Gulbahce, Han Yan, Amélie Dricot, Megha Padi, Danielle Byrdsong, Rachel Franchi, Deok-Sun Lee, Orit Rozenblatt-Rosen, Jessica C Mar, Michael A Calderwood, Amy Baldwin, Bo Zhao, Balaji Santhanam, Pascal Braun, Nicolas Simonis, Kyung-Won Huh, Karin Hellner, Miranda Grace, Alyce Chen, Renee Rubio, Jarrod A Marto, Nicholas A Christakis, Elliott Kieff, Frederick P Roth, Jennifer Roecklein-Canfield, James A Decaprio, Michael E Cusick, John Quackenbush, David E Hill, Karl Münger, Marc Vidal, Albert-László Barabási   +31 more
doaj   +1 more source

RNA Sequencing of Medusavirus Suggests Remodeling of the Host Nuclear Environment at an Early Infection Stage

Microbiology Spectrum, 2021
Viruses of the phylum Nucleocytoviricota, or nucleo-cytoplasmic large DNA viruses (NCLDVs), undergo a cytoplasmic or nucleo-cytoplasmic cycle, the latter of which involves both nuclear and cytoplasmic compartments to proceed viral replication ...
Ruixuan Zhang, Hisashi Endo, Masaharu Takemura, Hiroyuki Ogata   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Perfil transcricional de genes do sistema imune em litopenaeus vannamei desafiados com IMNV, após o silenciamento viral por RNAI [PDF]

, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biologia Celular e do Desenvolvimento, Florianópolis, 2015A incidência de doenças virais tem implicado em significativas perdas ...
Justino, Emily Bruna
core  

The influence of viral infection on a plankton ecosystem undergoing nutrient enrichment [PDF]

, 2010
It is increasingly recognised that viruses are a significant active component of oceanic plankton ecosystems. They play an important role in biogeochemical cycles as well as being implicated in observed patterns of species abundance and diversity.
Rhodes, C.J., Martin, A.P.
core   +1 more source

Computational analysis of microRNA-mediated interactions in SARS-CoV-2 infection [PDF]

PeerJ, 2020
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression found in more than 200 diverse organisms. Although it is still not fully established if RNA viruses could generate miRNAs, there are examples of miRNA like sequences from RNA ...
Müşerref Duygu Saçar Demirci, Aysun Adan   +1 more
doaj   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Degradation of cellular mir-27 by a novel, highly abundant viral transcript is important for efficient virus replication in vivo. [PDF]

, 2012
Cytomegaloviruses express large amounts of viral miRNAs during lytic infection, yet, they only modestly alter the cellular miRNA profile. The most prominent alteration upon lytic murine cytomegalovirus (MCMV) infection is the rapid degradation of the ...
Lisnić, V. (V) J. (J), Marcinowski, Lisa, Tanguy, M. (M), Ruzsics, Zsolt, Tanguy Mélanie, Ralf Zimmer, Jonjic, S. (S), Erhard, F. (F), Krmpotic Astrid, Marina Babic (184917), Corinna Benkartek, Bernd Rädle (138968), Zsolt Ruzsics, Babic, Marina, Ruzsics, Z. (Zsolt), Jonjic Stipan, Trgovcich, Joanne, Erhard, Florian, Chane-woon-ming, B. (Béatrice), Tanguy, Mélanie, Chane-Woon-Ming Béatrice, Koszinowski, U. (Ulrich H), Marcinowski Lisa, Marina Babic, Ulrich H Koszinowski, Koszinowski Ulrich H., Joanne Trgovcich (184921), Astrid Krmpotic (184892), Stipan Jonjic (139671), Stipan Jonjic, Babic Marina, Vanda J. Lisnić (184897), Krmpotic, A. (A), Sébastien Pfeffer, Benkartek Corinna, Zsolt Ruzsics (75383), Béatrice Chane-Woon-Ming (184904), Zimmer Ralf, Lisa Marcinowski (138962), Marcinowski, L. (L), Marcinowski, L. (Lisa), Krmpotic, Astrid, Dölken, Lars, Béatrice Chane-Woon-Ming, Joanne Trgovcich, Rädle Bernd, Trgovcich, J. (Joanne), Rädle, B. (Bernd), Lars Dölken, Astrid Krmpotic, Florian Erhard (184910), Lars Dölken (138985), Babic, M. (M), Jonjic, S. (Stipan), Ulrich H. Koszinowski (152143), Lisnić, Vanda J., Lisnić, V. (Vanda J), Trgovcich Joanne, Benkartek, Corinna, Zimmer, Ralf, Erhard Florian, Dölken Lars, Ruzsics, Z. (Z), Ralf Zimmer (21157), Rädle, B. (B), Dölken, L. (L), Vanda J Lisnić, Tuddenham, L. (Lee), Trgovcich, J. (J), Lisnić Vanda J., Lee Tuddenham (141455), Pfeffer, S. (Sebastien), Rädle, Bernd, Corinna Benkartek (184913), Lisa Marcinowski, Zimmer, R. (Ralf), Tuddenham Lee, Benkartek, C. (C), Lee Tuddenham, Erhard, F. (Florian), Pfeffer Sébastien, Babic, M. (Marina), Tuddenham, Lee, Mélanie Tanguy (4691986), Mélanie Tanguy, Florian Erhard, Koszinowski, U. (U) H. (H), Ruzsics Zsolt, Krmpotic, A. (Astrid), Koszinowski, Ulrich H., Tanguy, M. (Mélanie), Dölken, L. (Lars), Zimmer, R. (R), Chane-Woon-Ming, Béatrice, Bernd Rädle, Sébastien Pfeffer (8264), Pfeffer, Sébastien, Benkartek, C. (Corinna), Jonjic, Stipan   +98 more
core   +1 more source

The new era progress in immunotherapy of glioma

Chinese Journal of Contemporary Neurology and Neurosurgery, 2019
Glioma is the most common primary tumor of central nervous system (CNS), about 50% of which is extremely malignant glioblastoma (GBM). GBM is the most common primary malignant brain tumors in adults.
Bing⁃hao ZHAO, Ya⁃ning WANG, Li⁃zhou ZHOU, Cong⁃xin DAI, Yu WANG, Wen⁃bin MA   +5 more
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