Results 41 to 50 of about 1,028,945 (306)

Non-viral Gene Therapy for Osteoarthritis [PDF]

Frontiers in Bioengineering and Biotechnology, 2021
Strategies for delivering nucleic acids into damaged and diseased tissues have been divided into two major areas: viral and non-viral gene therapy. In this mini-review article we discuss the application of gene therapy for the treatment of osteoarthritis (OA), one of the most common forms of arthritis.
Ilona Uzieliene, Ursule Kalvaityte, Eiva Bernotiene, Ali Mobasheri, Ali Mobasheri, Ali Mobasheri, Ali Mobasheri   +6 more
openaire   +4 more sources

Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals. [PDF]

, 2016
IFIT (interferon-induced with tetratricopeptide repeats) proteins are critical mediators of mammalian innate antiviral immunity. Mouse IFIT1 selectively inhibits viruses that lack 2'O-methylation of their mRNA 5' caps.
Daugherty, Matthew D, Geballe, Adam P, Malik, Harmit S, Schaller, Aaron M   +3 more
core   +1 more source

Dietary energy drives the dynamic response of bovine rumen viral communities

Microbiome, 2017
Background Rumen microbes play a greater role in host energy acquisition than that of gut-associated microbes in monogastric animals. Although genome-enabled advancements are providing access to the vast diversity of uncultivated microbes, our ...
Christopher L. Anderson, Matthew B. Sullivan, Samodha C. Fernando   +2 more
doaj   +1 more source

Virioplankton assemblages from challenger deep, the deepest place in the oceans

iScience, 2022
Summary: Hadal ocean biosphere, that is, the deepest part of the world’s oceans, harbors a unique microbial community, suggesting a potential uncovered co-occurring virioplankton assemblage.
Chen Gao, Yantao Liang, Yong Jiang, David Paez-Espino, Meiaoxue Han, Chengxiang Gu, Meiwen Wang, Yumei Yang, Fengjiao Liu, Qingwei Yang, Zheng Gong, Xinran Zhang, Zhixiang Luo, Hui He, Cui Guo, Hongbing Shao, Chun Zhou, Yang Shi, Yu Xin, Jinyan Xing, Xuexi Tang, Qilong Qin, Yu-Zhong Zhang, Jianfeng He, Nianzhi Jiao, Andrew McMinn, Jiwei Tian, Curtis A. Suttle, Min Wang   +28 more
doaj   +1 more source

Assessment of viral community functional potential from viral metagenomes may be hampered by contamination with cellular sequences [PDF]

Open Biology, 2013
Although the importance of viruses in natural ecosystems is widely acknowledged, the functional potential of viral communities is yet to be determined. Viral genomes are traditionally believed to carry only those genes that are directly pertinent to the ...
Simon Roux, Mart Krupovic, Didier Debroas, Patrick Forterre, François Enault   +4 more
doaj   +1 more source

Viral gene drive in herpesviruses [PDF]

Nature Communications, 2019
AbstractHerpesviruses are ubiquitous pathogens in need of novel therapeutic solutions. Current engineered gene drive strategies rely on sexual reproduction, and are thought to be restricted to sexual organisms. Here, we report on the design of a novel gene drive system that allows the spread of an engineered trait in populations of DNA viruses and, in ...
Walter, Marius, Verdin, Eric
openaire   +3 more sources

Acute BVDV infection inhibits expression of interferon-stimulated genes during pregnancy recognition in bovine endometrium [PDF]

, 2017
Bovine viral diarrhea virus (BVDV) can evade host detection by downregulation of interferon signaling pathways. Infection of cows with noncytopathic (ncp) BVDV can cause early embryonic mortality. Upregulation of type I interferon stimulated genes (ISGs)
Abudureyimu, A, Barry, A T, Chauhan, L, Chen, X, Cheng, Z R, Oguejiofor, C F, Wathes, D C   +6 more
core   +1 more source

Hidden regulation of herpes simplex virus 1 pre-mRNA splicing and polyadenylation by virally encoded immediate early gene ICP27.

PLoS Pathogens, 2019
In contrast to human cells, very few HSV-1 genes are known to be spliced, although the same pre-mRNA processing machinery is shared. Here, through global analysis of splice junctions in cells infected with HSV-1 and an HSV-1 mutant virus with deletion of
Shuang Tang, Amita Patel, Philip R Krause   +2 more
doaj   +1 more source

Identification of a Proliferation Gene Cluster Associated with HPV E6/E7 Expression Level and Viral DNA Load in Invasive Cervical Carcinoma

, 2005
Specific HPV DNA sequences are associated with more than 90% of invasive carcinomas of the uterine cervix. Viral E6 and E7 oncogenes are key mediators in cell transformation by disrupting TP53 and RB pathways. To investigate molecular mechanisms involved
Anne de La Rochefordière, Christophe Rosty, Dafna Tsafrir, Eytan Domany, F Ferlay, François Radvanyi, Ilan Tsafrir, Jean Paul Thiery, Jérôme Couturier, Martine Peter, Michal Sheffer, Nicolas Stransky, Patricia de Crémoux, Rémy Salmon, Thierry Dorval, Xavier Sastre-Garau   +15 more
core   +1 more source

The Role of VP16 in the Life Cycle of Alphaherpesviruses

Frontiers in Microbiology, 2020
The protein encoded by the UL48 gene of alphaherpesviruses is named VP16 or alpha-gene-transactivating factor (α-TIF). In the early stage of viral replication, VP16 is an important transactivator that can activate the transcription of viral immediate ...
Dengjian Fan, Dengjian Fan, Dengjian Fan, Mingshu Wang, Mingshu Wang, Mingshu Wang, Anchun Cheng, Anchun Cheng, Anchun Cheng, Renyong Jia, Renyong Jia, Renyong Jia, Qiao Yang, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Ying Wu, Dekang Zhu, Dekang Zhu, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Shun Chen, Shun Chen, Shun Chen, Mafeng Liu, Mafeng Liu, Mafeng Liu, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Xumin Ou, Xumin Ou, Xumin Ou, Sai Mao, Sai Mao, Sai Mao, Qun Gao, Qun Gao, Qun Gao, Di Sun, Di Sun, Di Sun, Xingjian Wen, Xingjian Wen, Xingjian Wen, Yunya Liu, Yunya Liu, Yunya Liu, Yanling Yu, Yanling Yu, Yanling Yu, Ling Zhang, Ling Zhang, Ling Zhang, Bin Tian, Bin Tian, Leichang Pan, Leichang Pan, Xiaoyue Chen, Xiaoyue Chen, Xiaoyue Chen   +62 more
doaj   +1 more source