Results 41 to 50 of about 755,314 (318)

Virioplankton assemblages from challenger deep, the deepest place in the oceans

iScience, 2022
Summary: Hadal ocean biosphere, that is, the deepest part of the world’s oceans, harbors a unique microbial community, suggesting a potential uncovered co-occurring virioplankton assemblage.
Chen Gao, Yantao Liang, Yong Jiang, David Paez-Espino, Meiaoxue Han, Chengxiang Gu, Meiwen Wang, Yumei Yang, Fengjiao Liu, Qingwei Yang, Zheng Gong, Xinran Zhang, Zhixiang Luo, Hui He, Cui Guo, Hongbing Shao, Chun Zhou, Yang Shi, Yu Xin, Jinyan Xing, Xuexi Tang, Qilong Qin, Yu-Zhong Zhang, Jianfeng He, Nianzhi Jiao, Andrew McMinn, Jiwei Tian, Curtis A. Suttle, Min Wang   +28 more
doaj   +1 more source

Viral Vectors in Gene Therapy [PDF]

Diseases, 2018
Applications of viral vectors have found an encouraging new beginning in gene therapy in recent years. Significant improvements in vector engineering, delivery, and safety have placed viral vector-based therapy at the forefront of modern medicine. Viral vectors have been employed for the treatment of various diseases such as metabolic, cardiovascular ...
openaire   +3 more sources

Resisting viral infection: the gene by gene approach [PDF]

Current Opinion in Virology, 2011
This review focuses on genes required for resistance to mouse cytomegalovirus (MCMV), as identified through unbiased genetic screening. Components of the developmental, sensing, and effector pathways, functioning in multiple cell types, were detected by infecting 22,000 G3 mutant mice with MCMV at an inoculum easily contained by WT animals.
Eva Marie Y, Moresco, Bruce, Beutler
openaire   +2 more sources

Viral Hybrid Vectors for Somatic Integration - Are They the Better Solution? [PDF]

, 2009
The turbulent history of clinical trials in viral gene therapy has taught us important lessons about vector design and safety issues. Much effort was spent on analyzing genotoxicity after somatic integration of therapeutic DNA into the host genome. Based
Anja Ehrhardt, Nadine Müther, Ehrhardt, Anja, Nadja Noske, Müther, Nadine, Noske, Nadja, Nadine Müther   +6 more
core   +1 more source

Gene transfer by viral vectors for gene therapy [PDF]

Journal of Molecular Medicine, 1995
The search for useful virus vectors and for improvements in currently available retrovectors which may have the capability of transportation by natural transport systems in the human body will open effective ways for targeting human genes to specific cells in tissues in situ.
Y, Becker, G, Darai
openaire   +2 more sources

Hidden regulation of herpes simplex virus 1 pre-mRNA splicing and polyadenylation by virally encoded immediate early gene ICP27.

PLoS Pathogens, 2019
In contrast to human cells, very few HSV-1 genes are known to be spliced, although the same pre-mRNA processing machinery is shared. Here, through global analysis of splice junctions in cells infected with HSV-1 and an HSV-1 mutant virus with deletion of
Shuang Tang, Amita Patel, Philip R Krause   +2 more
doaj   +1 more source

Genomic architecture of endogenous ichnoviruses reveals distinct evolutionary pathways leading to virus domestication in parasitic wasps

BMC Biology, 2020
Background Polydnaviruses (PDVs) are mutualistic endogenous viruses inoculated by some lineages of parasitoid wasps into their hosts, where they facilitate successful wasp development.
Fabrice Legeai, Bernardo F. Santos, Stéphanie Robin, Anthony Bretaudeau, Rebecca B. Dikow, Claire Lemaitre, Véronique Jouan, Marc Ravallec, Jean-Michel Drezen, Denis Tagu, Frédéric Baudat, Gabor Gyapay, Xin Zhou, Shanlin Liu, Bruce A. Webb, Seán G. Brady, Anne-Nathalie Volkoff   +16 more
doaj   +1 more source

The Role of VP16 in the Life Cycle of Alphaherpesviruses

Frontiers in Microbiology, 2020
The protein encoded by the UL48 gene of alphaherpesviruses is named VP16 or alpha-gene-transactivating factor (α-TIF). In the early stage of viral replication, VP16 is an important transactivator that can activate the transcription of viral immediate ...
Dengjian Fan, Dengjian Fan, Dengjian Fan, Mingshu Wang, Mingshu Wang, Mingshu Wang, Anchun Cheng, Anchun Cheng, Anchun Cheng, Renyong Jia, Renyong Jia, Renyong Jia, Qiao Yang, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Ying Wu, Dekang Zhu, Dekang Zhu, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Shun Chen, Shun Chen, Shun Chen, Mafeng Liu, Mafeng Liu, Mafeng Liu, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Xumin Ou, Xumin Ou, Xumin Ou, Sai Mao, Sai Mao, Sai Mao, Qun Gao, Qun Gao, Qun Gao, Di Sun, Di Sun, Di Sun, Xingjian Wen, Xingjian Wen, Xingjian Wen, Yunya Liu, Yunya Liu, Yunya Liu, Yanling Yu, Yanling Yu, Yanling Yu, Ling Zhang, Ling Zhang, Ling Zhang, Bin Tian, Bin Tian, Leichang Pan, Leichang Pan, Xiaoyue Chen, Xiaoyue Chen, Xiaoyue Chen   +62 more
doaj   +1 more source

Complete genome viral phylogenies suggests the concerted evolution of regulatory cores and accessory satellites. [PDF]

PLoS ONE, 2008
We consider the concerted evolution of viral genomes in four families of DNA viruses. Given the high rate of horizontal gene transfer among viruses and their hosts, it is an open question as to how representative particular genes are of the evolutionary ...
Paolo Marinho de Andrade Zanotto, David C Krakauer   +1 more
doaj   +1 more source

Gene Targeting with Viral Vectors

Molecular Therapy, 2005
Genetic manipulation of cells for scientific and therapeutic goals can be achieved by both gene-addition and gene-targeting methods. Gene targeting precisely alters a gene in its natural chromosome location, providing distinct advantages over gene-addition approaches.
Hendrie, Paul C., Russell, David W.
openaire   +2 more sources