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Epigenetic control of Epstein–Barr virus transcription – relevance to viral life cycle? [PDF]
, 2013 DNA methylation normally leads to silencing of gene expression but Epstein–Barr virus (EBV) provides an exception to the epigenetic paradigm. DNA methylation is absolutely required for the expression of many viral genes.
Sinclair, Alison J
core +2 more sources
Journal of Orofacial Sciences, 2013 Gene therapy "the use of genes as medicine" involves the transfer of a therapeutic or working copy of a gene into specific cells of an individual in order to repair a faulty gene copy. The technique may be used to replace a faulty gene, or to introduce a
Sudip Indu +3 more
doaj +1 more source
Tissue Tropism in Host Transcriptional Response to Members of the Bovine Respiratory Disease Complex. [PDF]
, 2017 Bovine respiratory disease (BRD) is the most common infectious disease of beef and dairy cattle and is characterized by a complex infectious etiology that includes a variety of viral and bacterial pathogens.
Behura, Susanta K +11 more
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CRISPR Spacers Indicate Preferential Matching of Specific Virioplankton Genes
mBio, 2019 Viral infection exerts selection pressure on marine microbes, as virus-induced cell lysis causes 20 to 50% of cell mortality, resulting in fluxes of biomass into oceanic dissolved organic matter.
Daniel J. Nasko +5 more
doaj +1 more source
Identification of the Immediate-Early Genes of Cyprinid Herpesvirus 2
Viruses, 2020 Cyprinid herpesvirus 2 (CyHV-2), which infects goldfish and crucian carp causing high mortality, is an emerging viral pathogen worldwide. The genome of CyHV-2 is large and comprises double-stranded DNA, including several genes similar to cyprinid ...
Ruizhe Tang +4 more
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Interferon-induced genes of the expanded IFIT family show conserved antiviral activities in non-mammalian species. [PDF]
PLoS ONE, 2014 Interferon-induced proteins with tetratricopeptide repeats (IFITs) are involved in the protective response to viral infection, although the precise mechanism of IFITs for reducing viral proliferation is currently unknown.
Mónica Varela +8 more
doaj +1 more source
Reads Binning Improves the Assembly of Viral Genome Sequences From Metagenomic Samples
Frontiers in Microbiology, 2021 Metagenomes can be considered as mixtures of viral, bacterial, and other eukaryotic DNA sequences. Mining viral sequences from metagenomes could shed insight into virus–host relationships and expand viral databases.
Kai Song
doaj +1 more source
RNA-binding protein CPEB1 remodels host and viral RNA landscapes. [PDF]
, 2016 Host and virus interactions occurring at the post-transcriptional level are critical for infection but remain poorly understood. Here, we performed comprehensive transcriptome-wide analyses revealing that human cytomegalovirus (HCMV) infection results in
Aigner, Stefan +17 more
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Divergent Traits and Ligand-Binding Properties of the Cytomegalovirus CD48 Gene Family
Viruses, 2020 The genesis of gene families by the capture of host genes and their subsequent duplication is a crucial process in the evolution of large DNA viruses. CD48 is a cell surface molecule that interacts via its N-terminal immunoglobulin (Ig) domain with the ...
Pablo Martínez-Vicente +3 more
doaj +1 more source
Viral Vector-Based Gene Therapy
International Journal of Molecular Sciences, 2023 Gene therapy is a technique involving the modification of an individual’s genes for treating a particular disease. The key to effective gene therapy is an efficient carrier delivery system. Viral vectors that have been artificially modified to lose their pathogenicity are used widely as a delivery system, with the key advantages of their natural high ...
Xuedan Li +5 more
openaire +2 more sources