Results 11 to 20 of about 750,648 (173)
Scientific Reports, 2021 Sex-specific differences in prevalence are well documented for many common, complex diseases, especially for immune-mediated diseases, yet the precise mechanisms through which factors associated with biological sex exert their effects throughout life are
Michelle M. Stein +8 more
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SeXY chromosomes and the immune system: reflections after a comparative study
Biology of Sex Differences, 2020 Background Sex bias in immune function has been contributed in part to a preponderance of immune system-related genes (ISRG) on the X-chromosome. We verified whether ISRG are more abundant on the X chromosome as compared to autosomal chromosomes and ...
Irene Meester +7 more
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Dosage sensitivity of X-linked genes in human embryonic single cells
BMC Genomics, 2019 Background During the evolution of mammalian sex chromosomes, the degeneration of Y-linked homologs has led to a dosage imbalance between X-linked and autosomal genes.
Jian-Rong Yang, Xiaoshu Chen
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Faster-X evolution of gene expression in Drosophila. [PDF]
PLoS Genetics, 2012 DNA sequences on X chromosomes often have a faster rate of evolution when compared to similar loci on the autosomes, and well articulated models provide reasons why the X-linked mode of inheritance may be responsible for the faster evolution of X-linked ...
Richard P Meisel +2 more
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X-linked genes and mental functioning [PDF]
Human Molecular Genetics, 2005 The X-chromosome has played a crucial role in the development of sexually selected characteristics for over 300 million years. During that time it has accumulated a disproportionate number of genes concerned with mental functions. Evidence is emerging, from studies of both humans and mice, for a general influence upon intelligence (as indicated by the ...
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BMC Biology, 2011 Background Paucity of male-biased genes on the Drosophila X chromosome is a well-established phenomenon, thought to be specifically linked to the role of these genes in reproduction and/or their expression in the meiotic male germline.
Nurminsky Dmitry I +1 more
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Frontiers in Genetics, 2021 Klinefelter syndrome (KS) displays a broad dysmorphological, endocrinological, and neuropsychological clinical spectrum. We hypothesized that the neurocognitive dysfunction present in KS relies on an imbalance in X-chromosome gene expression. Thus, the X-
Luciane Simonetti +11 more
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Dosage regulation of the active X chromosome in human triploid cells. [PDF]
PLoS Genetics, 2009 In mammals, dosage compensation is achieved by doubling expression of X-linked genes in both sexes, together with X inactivation in females. Up-regulation of the active X chromosome may be controlled by DNA sequence-based and/or epigenetic mechanisms ...
Xinxian Deng +5 more
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EBioMedicine, 2015 Background: Psychiatric disorders are common mental disorders without a pathological biomarker. Classic genetic studies found that an extra X chromosome frequently causes psychiatric symptoms in patients with either Klinefelter syndrome (XXY) or Triple X
Baohu Ji +3 more
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A gradual process of recombination restriction in the evolutionary history of the sex chromosomes in dioecious plants. [PDF]
PLoS Biology, 2005 To help understand the evolution of suppressed recombination between sex chromosomes, and its consequences for evolution of the sequences of Y-linked genes, we have studied four X-Y gene pairs, including one gene not previously characterized, in plants ...
Michael Nicolas +9 more
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