Results 11 to 20 of about 919,210 (312)
Dosage sensitivity of X-linked genes in human embryonic single cells
BMC Genomics, 2019 Background During the evolution of mammalian sex chromosomes, the degeneration of Y-linked homologs has led to a dosage imbalance between X-linked and autosomal genes.
Jian-Rong Yang, Xiaoshu Chen
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Dosage compensation in the mouse balances up-regulation and silencing of X-linked genes. [PDF]
PLoS Biology, 2007 Dosage compensation in mammals involves silencing of one X chromosome in XX females and requires expression, in cis, of Xist RNA. The X to be inactivated is randomly chosen in cells of the inner cell mass (ICM) at the blastocyst stage of development ...
Hong Lin +6 more
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PLoS ONE, 2015 X-linked Intellectual Disability (XLID) is a group of genetically heterogeneous disorders caused by mutations in genes on the X chromosome. Deleterious mutations in ~10% of X chromosome genes are implicated in causing XLID disorders in ~50% of known and ...
Tejasvi S Niranjan +7 more
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The Application of Clinical Genetics, 2015 Christoph Wiesinger,1 Florian S Eichler,2 Johannes Berger1 1Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Vienna, Austria; 2Department for Neurology, Massachusetts General Hospital, Harvard ...
Wiesinger C, Eichler FS, Berger J
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Regulation of Male Fertility by X‐Linked Genes [PDF]
Journal of Andrology, 2010 ABSTRACT: Infertility is a worldwide reproductive health problem, affecting men and women about equally. Mouse genetic studies demonstrate that more than 200 genes specifically or predominantly regulate fertility. However, few genetic causes of infertility in humans have been identified.
Ke, Zheng +2 more
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Scientific Reports, 2021 Sex-specific differences in prevalence are well documented for many common, complex diseases, especially for immune-mediated diseases, yet the precise mechanisms through which factors associated with biological sex exert their effects throughout life are
Michelle M. Stein +8 more
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SeXY chromosomes and the immune system: reflections after a comparative study
Biology of Sex Differences, 2020 Background Sex bias in immune function has been contributed in part to a preponderance of immune system-related genes (ISRG) on the X-chromosome. We verified whether ISRG are more abundant on the X chromosome as compared to autosomal chromosomes and ...
Irene Meester +7 more
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A multispecies approach for comparing sequence evolution of X-linked and autosomal sites in Drosophila [PDF]
, 2008 Population genetics models show that, under certain conditions, the X chromosome is expected to be under more efficient selection than the autosomes.
Vicoso, Beatriz +3 more
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Faster-X evolution of gene expression in Drosophila. [PDF]
PLoS Genetics, 2012 DNA sequences on X chromosomes often have a faster rate of evolution when compared to similar loci on the autosomes, and well articulated models provide reasons why the X-linked mode of inheritance may be responsible for the faster evolution of X-linked ...
Richard P Meisel +2 more
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X-linked genes and mental functioning [PDF]
Human Molecular Genetics, 2005 The X-chromosome has played a crucial role in the development of sexually selected characteristics for over 300 million years. During that time it has accumulated a disproportionate number of genes concerned with mental functions. Evidence is emerging, from studies of both humans and mice, for a general influence upon intelligence (as indicated by the ...
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