Results 11 to 20 of about 818,208 (218)

SeXY chromosomes and the immune system: reflections after a comparative study

Biology of Sex Differences, 2020
Background Sex bias in immune function has been contributed in part to a preponderance of immune system-related genes (ISRG) on the X-chromosome. We verified whether ISRG are more abundant on the X chromosome as compared to autosomal chromosomes and ...
Irene Meester, Edgar Manilla-Muñoz, Rafael B. R. León-Cachón, Gustavo A. Paniagua-Frausto, Diego Carrión-Alvarez, C. Orelli Ruiz-Rodríguez, Ximena Rodríguez-Rangel, Joyce M. García-Martínez   +7 more
doaj   +1 more source

Dosage sensitivity of X-linked genes in human embryonic single cells

BMC Genomics, 2019
Background During the evolution of mammalian sex chromosomes, the degeneration of Y-linked homologs has led to a dosage imbalance between X-linked and autosomal genes.
Jian-Rong Yang, Xiaoshu Chen
doaj   +1 more source

Faster-X evolution of gene expression in Drosophila. [PDF]

PLoS Genetics, 2012
DNA sequences on X chromosomes often have a faster rate of evolution when compared to similar loci on the autosomes, and well articulated models provide reasons why the X-linked mode of inheritance may be responsible for the faster evolution of X-linked ...
Richard P Meisel, John H Malone, Andrew G Clark   +2 more
doaj   +1 more source

Lack of global meiotic sex chromosome inactivation, and paucity of tissue-specific gene expression on the Drosophila X chromosome

BMC Biology, 2011
Background Paucity of male-biased genes on the Drosophila X chromosome is a well-established phenomenon, thought to be specifically linked to the role of these genes in reproduction and/or their expression in the meiotic male germline.
Nurminsky Dmitry I, Mikhaylova Lyudmila M   +1 more
doaj   +1 more source

Intelligence Quotient Variability in Klinefelter Syndrome Is Associated With GTPBP6 Expression Under Regulation of X-Chromosome Inactivation Pattern

Frontiers in Genetics, 2021
Klinefelter syndrome (KS) displays a broad dysmorphological, endocrinological, and neuropsychological clinical spectrum. We hypothesized that the neurocognitive dysfunction present in KS relies on an imbalance in X-chromosome gene expression. Thus, the X-
Luciane Simonetti, Lucas G. A. Ferreira, Lucas G. A. Ferreira, Angela Cristina Vidi, Angela Cristina Vidi, Janaina Sena de Souza, Ilda S. Kunii, Maria Isabel Melaragno, Claudia Berlim de Mello, Gianna Carvalheira, Magnus R. Dias da Silva, Magnus R. Dias da Silva   +11 more
doaj   +1 more source

Over-expression of XIST, the Master Gene for X Chromosome Inactivation, in Females With Major Affective Disorders

EBioMedicine, 2015
Background: Psychiatric disorders are common mental disorders without a pathological biomarker. Classic genetic studies found that an extra X chromosome frequently causes psychiatric symptoms in patients with either Klinefelter syndrome (XXY) or Triple X
Baohu Ji, Kerin K. Higa, John R. Kelsoe, Xianjin Zhou   +3 more
doaj   +1 more source

A gradual process of recombination restriction in the evolutionary history of the sex chromosomes in dioecious plants. [PDF]

PLoS Biology, 2005
To help understand the evolution of suppressed recombination between sex chromosomes, and its consequences for evolution of the sequences of Y-linked genes, we have studied four X-Y gene pairs, including one gene not previously characterized, in plants ...
Michael Nicolas, Gabriel Marais, Vladka Hykelova, Bohuslav Janousek, Valérie Laporte, Boris Vyskot, Dominique Mouchiroud, Ioan Negrutiu, Deborah Charlesworth, Françoise Monéger   +9 more
doaj   +1 more source

Data for identification of porcine X-chromosome inactivation center, XIC, by genomic comparison with human and mouse XIC

Data in Brief, 2015
The data included in this article shows homologies of genes in porcine X-chromosome inactivation center, XIC, to each orthologue in human and mouse XIC.
Jae Yeon Hwang, Kwang-Hwan Choi, Chang-Kyu Lee   +2 more
doaj   +1 more source

Dosage regulation of the active X chromosome in human triploid cells. [PDF]

PLoS Genetics, 2009
In mammals, dosage compensation is achieved by doubling expression of X-linked genes in both sexes, together with X inactivation in females. Up-regulation of the active X chromosome may be controlled by DNA sequence-based and/or epigenetic mechanisms ...
Xinxian Deng, Di Kim Nguyen, R Scott Hansen, Daniel L Van Dyke, Stanley M Gartler, Christine M Disteche   +5 more
doaj   +1 more source

A familial case of diffuse periventricular nodular heterotopia identified prenatally: Filamin A defect as the probable cause

Radiology Case Reports
Periventricular nodular heterotopia (PNH) is a neuronal migration defect characterized by the presence of ectopic grey matter nodules adjacent to the walls of the lateral ventricles.
Mariana Tomásio Neves, MD, André Luís Borges, MD, Guilherme Martins, MD, Graça Sá, MD, Teresa Loureiro, PhD, Oana Moldovan, MD   +5 more
doaj   +1 more source