Results 141 to 150 of about 17,032 (179)

Epigenetic agents, zebularine and valproic acid, inhibit the growth of the oral squamous cell carcinoma cell line HSC4 in vitro and in vivo

Discover Oncology
This study explored the potential of Zebularine (Zeb), a DNA methyltransferase inhibitor (DNMTi), and Valproic acid (Vpa), a histone deacetylase inhibitor (HDACi), as a combined treatment strategy for OSCC. OSCC cell lines, HSC4 (well-differentiated type)
Shuhei Takahashi, Koki Yoshida, Durga Paudel, Tetsuro Morikawa, O. Uehara, F. Harada, Dedy Ariwansa, Sarita Giri, J. Sato, Hiroki Nagayasu, Yoshihiro Abiko   +10 more
semanticscholar   +1 more source

The lactate-GPR81-AMIGO2 axis promotes pancreatic ductal adenocarcinoma progression and predicts poor prognosis.

Cellular Signalling
Pancreatic ductal adenocarcinoma (PDAC) carries an extremely poor prognosis. Excessive lactate accumulation occurs in the hypoxic tumor microenvironment, yet the roles of lactate receptor GPR81 and adhesion molecule AMIGO2 and their crosstalk in PDAC ...
Qiannan Zhang, Lishan Wang, Zeqian Yu, Tonglei Xu, Jiaping Tang, Zhu Zhu, Jiahua Zhou   +6 more
semanticscholar   +1 more source

FTO-mediated regulation of m6A methylation is closely related to apoptosis induced by repeated UV irradiation.

Journal of dermatological science (Amsterdam)
BACKGROUND Ultraviolet (UV) damage is closely related to skin photoaging and many skin diseases, including dermatic tumors. N6-methyladenosine (m6A) modification is an important epigenetic regulatory mechanism.
Yao Lin, Yu Sun, Wenyi Hou, Xinling Chen, Feng Zhou, Qingfang Xu, Yue Zheng   +6 more
semanticscholar   +1 more source

Abstract A016: NXP800, a novel, small molecule GCN2 kinase activator, demonstrates potent single-agent activity in ARID1A and ARID1B-deficient endometrial cancer xenograft models

Clinical Cancer Research
Background: NXP800 is a clinical stage, antineoplastic, oral, small molecule GCN2 kinase activator that was discovered in a phenotypic screen for inhibitors of the heat shock factor 1-regulated stress response.
R. Eskander, B. J. Monk, B. Slomovitz, E. Poradosu, Allison Woods, S. Shemesh, Paul Clarke, R. te Poele, M. Powers, Paul Workman, S. Westin   +10 more
semanticscholar   +1 more source

Immunogenetic studies on the resistance of mice to highly metastatic DBA/2 tumor cell variants. I. Effect of incompatibilities at H-2 or non-H-2 genes in normal and nude (nu/nu) mice.

Invasion & metastasis, 1984
The ability of two highly metastatic tumor lines of DBA/2 (H-2d) origin to metastasize in various allogeneic normal or nude (nu/nu) mouse strains was investigated. Normal mice differing from DBA/2 at either the major histocompatibility complex or at minor histocompatibility loci were both able to reject rather high subcutaneous inocula of these tumor ...
openaire   +1 more source

Up-regulation of the expressions of MiR-149-5p and MiR-99a-3p in exosome inhibits the progress of pituitary adenomas

Cell Biology and Toxicology, 2021
P. Zhao, Jianhua Cheng, Bin Li, Ding Nie, Chuzhong Li, S. Gui, Hongyun Wang, Yazhuo Zhang   +7 more
semanticscholar   +1 more source

Grape and wine polyphenols down-regulate the expression of signal transduction genes and inhibit the growth of estrogen receptor-negative MDA-MB231 tumors in nu/nu mouse xenografts.

Nutrition Research, 2008
F. Hakimuddin, Krishnaraj Tiwari, G. Paliyath, K. Meckling   +3 more
semanticscholar   +1 more source

Rearrangement patterns of T-cell receptor genes in the spleen of athymic (nu/nu) young mice

Immunogenetics, 2004
R. Palacios, J. Samaridis
semanticscholar   +1 more source

New member of the winged-helix protein family disrupted in mouse and rat nude mutations

Nature, 1994
M. Nehls, D. Pfeifer, M. Schorpp, H. Hedrich, T. Boehm   +4 more
semanticscholar   +1 more source

Development of the Nude Rabbit Model

Stem Cell Reports, 2021
Jun Song, Mark J Hoenerhoff, Dongshan Yang   +2 more
exaly