Results 111 to 120 of about 7,597,050 (334)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Cyanolichen microbiome contains novel viruses that encode genes to promote microbial metabolism [PDF]

, 2021
Alise J. Ponsero, Bonnie L. Hurwitz, Nicolas Magain, Jolanta Miądlikowska, François Lutzoni, Jana M. U’Ren   +5 more
openalex   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Review: Rethinking environmental enrichment as providing opportunities to acquire information

Animal
Environmental enrichment, that is making the environment of animals more complex, was first designed to enhance the welfare and cognitive abilities of captive animals, and was more recently applied to farm animals.
I. Veissier, C. Lesimple, V. Brunet, L. Aubé, R. Botreau   +4 more
doaj   +1 more source

Foxg1 deletion impairs the development of the epithalamus

Molecular Brain, 2018
The epithalamus, which is dorsal to the thalamus, consists of the habenula, pineal gland and third ventricle choroid plexus and plays important roles in the stress response and sleep–wake cycle in vertebrates.
Bin Liu, Kaixing Zhou, Xiaojing Wu, Chunjie Zhao   +3 more
doaj   +1 more source

Gap-enhanced Raman tags for physically unclonable anticounterfeiting labels

Nature Communications, 2020
Physical unclonable functions with inherent randomness are promising candidates for secure labeling systems. Here the authors demonstrate such a function using gap-enhanced Raman tags to create high-capacity and high-security labels for ...
Yuqing Gu, Chang He, Yuqing Zhang, Li Lin, Benjamin David Thackray, Jian Ye   +5 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

DNA Transfection : Gene Regulation, Gene Amplification and Gene Cloning

Juntendo Medical Journal, 1986
DNA transfection is a powerful tool of gene analysis. Indeed it allows functional studies of genes either from high molecular weight cellular DNA ( i. e. in their physiological structure) or cloned in vectors ( i. e. amenable to manipulations designed to influence their function ).
Saverio Alberti, Leonard A. Herzenberg
openaire   +3 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Subclinical myocardial dysfunction detected by speckletracking in asymptomatic individuals with exerciseinduced premature ventricular complexes

Cardiovascular Ultrasound
Objective Exercise-induced premature ventricular complexes (EI-PVCs) are key indicators of subclinical cardiac dysfunction and elevated cardiovascular risk.
Muhammet Geneş, Uygar Çağdaş Yüksel
doaj   +1 more source