Results 111 to 120 of about 5,662,228 (148)

Analysis of Gene‐Gene Interactions

Current Protocols in Human Genetics, 2003
AbstractThe goal of this unit is to introduce gene‐gene interactions (epistasis) as a significant complicating factor in the search for disease susceptibility genes. This unit begins with an overview of gene‐gene interactions and why they are likely to be common.
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Tandem genes and clustered genes

Journal of Theoretical Biology, 1995
Two patterns of gene repetition are described: tandem arraying and clustering. Tandemly arrayed genes reside within segments of DNA that are repeated head-to-tail a number of times. Clustered genes are linked but irregularly spaced, are often mutually inverted in an unpredictable pattern and are connected by non-conserved DNA.
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Better Gene Expression by (-)Gene than by (+)Gene in Phage Gene Delivery Systems

Biotechnology Progress, 2006
In recent years, capsid-modified filamentous bacteriophage has become a potential vector for gene delivery into mammalian cells. However, little was known about how the carried gene in the single-stranded genome expressed in mammalian cells. To explore whether the orientation of the carried gene affects its expression in the cells, we prepared EGF ...
Yun, Liang, Bizhi, Shi, Jie, Zhang, Hua, Jiang, Yuhong, Xu, Zonghai, Li, Jianren, Gu   +6 more
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Gene Duplication and Gene Loading

2014
During the early evolution of life, gene duplication, the production of two copies of a DNA sequence, allowed the rapid diversification of enzymatically catalyzed reactions and an increase in genome size, providing also material for the invention of new enzymatic properties and complex regulatory and developmental patterns. A duplication may involve (i)
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Genes, genes, genes

The Lancet Oncology, 2013
Hogarth, Stuart, Sullivan, Richard
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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets.

Cell, 2005
Benjamin P. Lewis, C. Burge, D. Bartel
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PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Nature Genetics, 2003
V. Mootha, C. Lindgren, K. Eriksson, A. Subramanian, S. Sihag, J. Lehár, P. Puigserver, E. Carlsson, M. Ridderstråle, E. Laurila, Nicholas Houstis, M. Daly, N. Patterson, J. Mesirov, T. Golub, P. Tamayo, B. Spiegelman, E. Lander, J. Hirschhorn, D. Altshuler, L. Groop   +20 more
semanticscholar   +1 more source

The evolutionary fate and consequences of duplicate genes.

Science, 2000
M. Lynch, J. Conery
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Alzheimer's disease: genes, proteins, and therapy.

Physiological Reviews, 2001
D. Selkoe
semanticscholar   +1 more source

The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease

Science, 2006
J. Lamb, E. Crawford, David Peck, Joshua W. Modell, Irene C. Blat, Matthew J Wrobel, Jim Lerner, Jean-Philippe Brunet, A. Subramanian, K. Ross, Michael Reich, H. Hieronymus, G. Wei, S. Armstrong, S. Haggarty, P. Clemons, R. Wei, S. Carr, E. Lander, T. Golub   +19 more
semanticscholar   +1 more source