Results 141 to 150 of about 48,752 (282)
Evolution of Prime Editing: Enhancing Efficiency and Expanding Capacity
Advanced Science, EarlyView.Most rare diseases are caused by genetic mutations. Prime editing (PE) has emerged as a versatile tool capable of inducing diverse mutations without generating DNA double‐strand breaks. Despite its significant clinical potential, PE faces limitations in terms of efficiency and scalability.
Jihyeon Yu +5 more
wiley +1 more source
Development of usable grid services for the biomedical community [PDF]
, 2006 The BRIDGES project was funded by the UK Department of Trade and Industry to directly address the needs of the cardiovascular research scientists investigating the genetic causes of hypertension as part of the Wellcome Trust funded (£4.34M ...
Sinnott, R.O.
core
Abstract Microgravity constitutes one of the most profound environmental stressors encountered by humans during spaceflight, capable of altering fundamental cellular processes and gene regulatory networks. While the effects of spaceflight on well-characterized protein-coding genes have been widely documented, little is known about the ...
Özge Demir +6 more
openaire +1 more source
Wearable Thermoelectric Generators for In Vivo Modulation of Insulin Release
Advanced Energy Materials, EarlyView.This work presents a wearable, self‐powered thermoelectric system (IGNITE) that sustainably harvests body heat to electrically stimulate engineered human cells for insulin release. Operating autonomously without batteries, IGNITE achieves glycemic control in diabetic mice, demonstrating a significant advance in bioelectronic medicine and setting the ...
Debasis Maity +2 more
wiley +1 more source
A Novel Bioinformatic Approach to Understanding Addiction [PDF]
, 2017 Finding the genetic markers that influence complex, multigenic substance addiction phenotypes has been an area of significant medical study. Understanding complex disease traits like addiction has been hampered by the lack of functional insights into ...
Jackson, Latifa F.
core +1 more source
Advanced Intelligent Discovery, EarlyView.This article investigates how persistent homology, persistent Laplacians, and persistent commutative algebra reveal complementary geometric, topological, and algebraic invariants or signatures of real‐world data. By analyzing shapes, synthetic complexes, fullerenes, and biomolecules, the article shows how these mathematical frameworks enhance ...
Yiming Ren, Guo‐Wei Wei
wiley +1 more source
Metabolic stress in space: ROS-induced mutations in mice hint at a new path to cancer
Redox BiologyLong-duration spaceflight beyond Earth's magnetosphere poses serious health risks, including muscle atrophy, bone loss, liver and kidney damage, and the Spaceflight-Associated Neuro-ocular Syndrome (SANS).
Viktor Stolc +5 more
doaj +1 more source
A Review of Trans‐Dimensional Kirigami: From Compliant Mechanism to Multifunctional Robot
Advanced Intelligent Systems, EarlyView.This review outlines recent advancements in the geometric design and mechanical properties of kirigami. The kirigami is classified into two categories from a compliant mechanism perspective, highlighting their applications in metamaterials and robotic systems. Finally, the future research directions, is explored focusing on the potential of integrating
Yang Yu +14 more
wiley +1 more source
, 2004 Supported by Spanish Government Grants ESP2002-11913-E and ESP2003-09475-C01-
Marco, Roberto +8 more
openaire +1 more source
American Journal of Botany, EarlyView.Abstract Premise Flowers that present their anthers and stigma in close proximity can achieve precise animal‐mediated pollen transfer, but risk self‐pollination. One evolutionary solution is reciprocal herkogamy. Reciprocity of anther and style positions among different plants (i.e., a genetic dimorphism) is common in distylous plants, but very rare in
Steven D. Johnson +5 more
wiley +1 more source