Results 1 to 10 of about 2,230,593 (247)
Prevalence of insertion sequence elements in plasmids relating to mgrB gene disruption causing colistin resistance in Klebsiella pneumoniae [PDF]
MicrobiologyOpen, 2022 Colistin is a last resort antibiotic for the treatment of carbapenemase producing Klebsiella pneumoniae. The disruption of the mgrB gene by insertion sequences (ISs) is a mechanism mediating colistin resistance.
Stephen Mark Edward Fordham +2 more
doaj +3 more sources
Insertion sequence transposition inactivates CRISPR-Cas immunity [PDF]
Nature Communications, 2023 CRISPR-Cas immunity systems safeguard prokaryotic genomes by inhibiting the invasion of mobile genetic elements. Here, we screened prokaryotic genomic sequences and identified multiple natural transpositions of insertion sequences (ISs) into cas genes ...
Yong Sheng +9 more
doaj +2 more sources
No Isolate, No Problem: Using a Novel Insertion Sequence PCR to Link Rats to Human Shigellosis Cases in an Underserved Urban Community [PDF]
Microbiology Spectrum, 2023 During an investigation into a cluster of Shigella flexneri serotype 2a cases in an underserved community, we assessed the relatedness of human and rat S.
Gordon Ritchie +9 more
doaj +2 more sources
A more significant role for insertion sequences in large-scale rearrangements in bacterial genomes
mBioInsertion sequences (ISs) are mobile pieces of DNA that are widespread in bacterial genomes. IS movements typically involve (i) excision of the IS element, (ii) cutting of target site DNA, and (iii) IS element insertion. This process generates a new copy
Wing Y. Ngan +3 more
doaj +3 more sources
Insertion sequences disrupting mgrB in carbapenem-resistant Klebsiella pneumoniae strains in Brazil
Journal of Global Antimicrobial Resistance, 2021 Objectives: This study aimed to characterise insertional mutations disturbing themgrB gene in carbapenem-resistant Klebsiella pneumoniae (CRKp). Methods: A total of 118 clinical CRKp isolates were surveyed for polymyxin resistance and insertion sequence (
Daniely Martins da Silva +7 more
doaj +1 more source
Frontiers in Medicine, 2021 Gram-negative bacteria, especially Enterobacterales, have emerged as major players in antimicrobial resistance worldwide. Resistance may affect all major classes of anti-gram-negative agents, becoming multidrug resistant or even pan-drug resistant ...
Rémy A. Bonnin +20 more
doaj +1 more source
Antibiotics, 2021 Inactivation of the lipooligosaccharide (LOS) biosynthesis genes lpxA, lpxC and lpxD by ISAba insertion elements results in high-level resistance to colistin in A. baumannii.
Héctor Olmeda-López +2 more
doaj +1 more source
Polyclonal spread of blaOXA-23 and blaOXA-58 in Acinetobacter baumannii isolates from Argentina
Journal of Infection in Developing Countries, 2008 Background: In order to study the enzymatic carbapenem resistance mechanisms in Acinetobacter baumannii isolates from Argentina, we performed molecular characterization on 41 epidemiologically unrelated strains isolated from 1995 to 2006 with diminished ...
Andrea Karina Merkier +10 more
doaj +3 more sources
IS481EU Shows a New Connection between Eukaryotic and Prokaryotic DNA Transposons
Biology, 2023 DDD/E transposase gene is the most abundant gene in nature and many DNA transposons in all three domains of life use it for their transposition. A substantial number of eukaryotic DNA transposons show similarity to prokaryotic insertion sequences (ISs ...
Kenji K. Kojima, Weidong Bao
doaj +1 more source
Frontiers in Microbiology, 2021 Polymyxins are one of most important antibiotics available for multidrug-resistant Gram-negative infections. Diverse chromosomal resistance mechanisms have been described, but the polymyxin resistance phenotype is not yet completely understood.
Raquel Girardello +13 more
doaj +1 more source