Results 31 to 40 of about 2,230,593 (247)

A 19-nucleotide insertion in the leader sequence of avian leukosis virus subgroup J contributes to its replication in vitro but is not related to its pathogenicity in vivo. [PDF]

PLoS ONE, 2014
Subgroup J avian leukosis virus (ALV-J) was first isolated from meat-type chickens that had developed myeloid leukosis and since 2008, ALV-J infections in chickens have become widespread in China.
Xiaolin Ji, Qi Wang, Xiaofei Li, Xiaole Qi, Yongqiang Wang, Honglei Gao, Yulong Gao, Xiaomei Wang   +7 more
doaj   +1 more source

Mechanism of Sec61-mediated insertion of proteins into the endoplasmic reticulum membrane [PDF]

, 2010
In eukaryotic cells, hydrophobic signal sequences of newly synthesized secretory and membrane proteins target them to the Sec61 translocon in the endoplasmic reticulum (ER) membrane.
Kocik, Lucyna
core   +1 more source

Suppressible and nonsuppressible autocrine mast cell tumors are distinguished by insertion of an endogenous retroviral element (IAP) into the interleukin 3 gene [PDF]

, 1993
After v-H-ras expression, the interleukin 3 (IL-3)-dependent PB-3c mast cells progress in vivo to two different classes of IL-3 autocrine tumors. Class I tumors show a germline configuration of the IL-3 gene and represent more than 90% of tumors analyzed
Nair, A. P., Hirsch, H. H., A P Nair, Moroni, C., C Moroni, H H Hirsch   +5 more
core   +1 more source

Role of the N-terminal seven residues of surfactant protein B (SP-B). [PDF]

PLoS ONE, 2013
Breathing is enabled by lung surfactant, a mixture of proteins and lipids that forms a surface-active layer and reduces surface tension at the air-water interface in lungs. Surfactant protein B (SP-B) is an essential component of lung surfactant. In this
Mahzad Sharifahmadian, Muzaddid Sarker, Dharamaraju Palleboina, Alan J Waring, Frans J Walther, Michael R Morrow, Valerie Booth   +6 more
doaj   +1 more source

MOSAL : software tools for multiobjective sequence alignment [PDF]

, 2014
Multiobjective sequence alignment brings the advantage of providing a set of alignments that represent the trade-off between performing insertion/deletions and matching symbols from both sequences. Each of these alignments provide a potential explanation
Monsanto Pinheiro, Miguel, Maryam Abbasi, Luís LuísPaquete, Paquete, Luís, Pedro Matias, Luís Paquete, Abbasi, Maryam, Miguel Pinheiro, Matias, Pedro   +8 more
core   +1 more source

High Prevalence of Intra-Familial Co-colonization by Extended-Spectrum Cephalosporin Resistant Enterobacteriaceae in Preschool Children and Their Parents in Dutch Households

Frontiers in Microbiology, 2018
Extended-spectrum cephalosporin-resistant (ESCR) Enterobacteriaceae pose a serious infection control challenge for public health. The emergence of the ESCR phenotype is mostly facilitated by plasmid-mediated horizontal extended-spectrum β-lactamases ...
Apostolos Liakopoulos, Gerrita van den Bunt, Gerrita van den Bunt, Yvon Geurts, Martin C. J. Bootsma, Martin C. J. Bootsma, Mark Toleman, Daniela Ceccarelli, Wilfrid van Pelt, Dik J. Mevius, Dik J. Mevius   +10 more
doaj   +1 more source

Cross-species chimeras reveal BamA POTRA and β-barrel domains must be fine-tuned for efficient OMP insertion [PDF]

, 2015
BAM is a conserved molecular machine, the central component of which is BamA. Orthologues of BamA are found in all Gram-negative bacteria, chloroplasts and mitochondria where it is required for the folding and insertion of β-barrel containing integral ...
Jeeves, Mark, Mason, Jessica L, Knowles, Timothy J., Rossiter, Amanda E, Rossiter, Amanda E.; id_orcid, Browning, Douglas F., Bavro, Vassiliy N., Henderson, Ian R., Cunningham, Adam F., Overduin, Michael, Sevastsyanovich, Yanina R., Rossiter, Amanda E., Donald, James W., Browning, Douglas F, Wells, Timothy J, Henderson, Ian R, Knowles, Timothy J.; id_orcid, Wells, Timothy J., Palmer, Tracy, Knowles, Timothy J, Sevastsyanovich, Yanina R, Cunningham, Adam F, Mason, Jessica L., Bavro, Vassiliy N, Donald, James W   +24 more
core   +1 more source

To Be or Not to Be Mesophilic, That Is the Question for Aeromonas salmonicida

Microorganisms, 2022
The bacterium Aeromonas salmonicida has long been known to be one of the most feared pathogens in fish farming. However, the more we discover about this bacterial species, the more we question whether it is really exclusively an aquatic pathogen.
Antony T. Vincent, Steve J. Charette
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Evolutionary blueprint for host- and niche-adaptation in Staphylococcus aureus clonal complex CC30

Frontiers in Cellular and Infection Microbiology, 2012
Staphylococcus aureus clonal complex CC30 has caused infectious epidemics for more than 60 years, and therefore provides a model system to evaluate how evolution has influenced the disease potential of closely related strains. In previous multiple genome
Martin John Mcgavin, Benjamin eArsic, Nicholas Neil Nickerson   +2 more
doaj   +1 more source