Results 31 to 40 of about 375,981 (258)
Development of a Biocontained Toluene-Degrading Bacterium for Environmental Protection
Microbiology Spectrum, 2021 Biocontainment is a safeguard strategy for preventing uncontrolled proliferation of genetically engineered microorganisms (GEMs) in the environment. Biocontained GEMs are designed to survive only in the presence of a specific molecule.
Masahito Ishikawa +2 more
doaj +1 more source
On the stability of sequences inserted into viral genomes [PDF]
Virus Evolution, 2019 AbstractViruses are widely used as vectors for heterologous gene expression in cultured cells or natural hosts, and therefore a large number of viruses with exogenous sequences inserted into their genomes have been engineered. Many of these engineered viruses are viable and express heterologous proteins at high levels, but the inserted sequences often ...
Anouk Willemsen, Mark P Zwart
openaire +2 more sources
Frontiers in Microbiology, 2018 Extended-spectrum cephalosporin-resistant (ESCR) Enterobacteriaceae pose a serious infection control challenge for public health. The emergence of the ESCR phenotype is mostly facilitated by plasmid-mediated horizontal extended-spectrum β-lactamases ...
Apostolos Liakopoulos +10 more
doaj +1 more source
Insertion Transformer: Flexible Sequence Generation via Insertion Operations
CoRR, 2019 We present the Insertion Transformer, an iterative, partially autoregressive model for sequence generation based on insertion operations. Unlike typical autoregressive models which rely on a fixed, often left-to-right ordering of the output, our approach accommodates arbitrary orderings by allowing for tokens to be inserted anywhere in the sequence ...
Mitchell Stern +3 more
openaire +3 more sources
Evolutionary blueprint for host- and niche-adaptation in Staphylococcus aureus clonal complex CC30
Frontiers in Cellular and Infection Microbiology, 2012 Staphylococcus aureus clonal complex CC30 has caused infectious epidemics for more than 60 years, and therefore provides a model system to evaluate how evolution has influenced the disease potential of closely related strains. In previous multiple genome
Martin John Mcgavin +2 more
doaj +1 more source
Mobile DNA, 2022 The insertion sequence IS26 has long been known to play a major role in the recruitment of antibiotic resistance genes into the mobile resistance gene pool of Gram-negative bacteria and IS26 also plays a major role in their subsequent broad dissemination.
Ruth M. Hall
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Hemophilic arthropathy remains the leading morbidity in hemophilia despite modern prophylaxis, and early joint damage may be missed by routine exams. This study explored T2* MRI as a noninvasive biomarker of hemosiderin deposition in pediatric hemophilia.
Jessica Garcia +6 more
wiley +1 more source
Insertion variants missing in the human reference genome are widespread among human populations
BMC Biology, 2020 Background Structural variants comprise diverse genomic arrangements including deletions, insertions, inversions, and translocations, which can generally be detected in humans through sequence comparison to the reference genome. Among structural variants,
Young-gun Lee +3 more
doaj +1 more source
Palidis: fast discovery of novel insertion sequences
Microbial Genomics, 2022 Abstract The diversity of microbial insertion sequences, crucial mobile genetic elements in generating diversity in microbial genomes, needs to be better represented in current microbial databases. Identification of these sequences in microbiome communities presents some significant problems that have led to their underrepresentation ...
V.R. Carr (Victoria) +5 more
openaire +8 more sources
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source