Results 41 to 50 of about 773,035 (293)

Rapid Targeted Gene Disruption in Bacillus Anthracis [PDF]

, 2013
Anthrax is a zoonotic disease recognized to affect herbivores since Biblical times and has the widest range of susceptible host species of any known pathogen.
Ellington, Andrew, Kramer, Ryan, Lambowitz, Alan M., Lamkin, Thomas J., Pemberton, Adin, Perutka, Jiri, Saldanha, Roland J., Shiflett, Patrick, Taylor, Deborah, Whitt, Jacob T.   +9 more
core   +3 more sources

Evolutionary blueprint for host- and niche-adaptation in Staphylococcus aureus clonal complex CC30

Frontiers in Cellular and Infection Microbiology, 2012
Staphylococcus aureus clonal complex CC30 has caused infectious epidemics for more than 60 years, and therefore provides a model system to evaluate how evolution has influenced the disease potential of closely related strains. In previous multiple genome
Martin John Mcgavin, Benjamin eArsic, Nicholas Neil Nickerson   +2 more
doaj   +1 more source

Digital search trees and chaos game representation [PDF]

, 2006
In this paper, we consider a possible representation of a DNA sequence in a quaternary tree, in which on can visualize repetitions of subwords. The CGR-tree turns a sequence of letters into a digital search tree (DST), obtained from the suffixes of the ...
Chauvin, Brigitte, Cénac, Peggy, Ginouillac, Stéphane, Pouyanne, Nicolas   +3 more
core   +3 more sources

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Zinc-Induced Transposition of Insertion Sequence Elements Contributes to Increased Adaptability of Cupriavidus metallidurans

Frontiers in Microbiology, 2016
Bacteria can respond to adverse environments by increasing their genomic variability and subsequently facilitating adaptive evolution. To demonstrate this, the contribution of Insertion Sequence (IS) elements to the genetic adaptation of Cupriavidus ...
Joachim eVandecraen, Joachim eVandecraen, Pieter eMonsieurs, Max eMergeay, Natalie eLeys, Abram eAertsen, Rob eVan Houdt   +6 more
doaj   +1 more source

Comment on “the IS6 family, a clinically important group of insertion sequences including IS26” by Varani and co-authors

Mobile DNA, 2022
The insertion sequence IS26 has long been known to play a major role in the recruitment of antibiotic resistance genes into the mobile resistance gene pool of Gram-negative bacteria and IS26 also plays a major role in their subsequent broad dissemination.
Ruth M. Hall
doaj   +1 more source

Import of honeybee prepromelittin into the endoplasmic reticulum [PDF]

, 1987
Honeybee prepromelittin is correctly processed and imported by dog pancreas microsomes. Insertion of prepromelittin into microsomal membranes, as assayed by signal sequence removal, does not depend on signal recognition particle (SRP) and docking protein.
Müller, Günter, Zimmermann, Richard
core   +2 more sources

Multiple determinants direct the orientation of signal-anchor proteins : the topogenic role of the hydrophobic signal domain [PDF]

, 1997
The orientation of signal-anchor proteins in the endoplasmic reticulum membrane is largely determined by the charged residues flanking the apolar, membrane-spanning domain and is influenced by the folding properties of the NH2-terminal sequence. However,
Andrews, Beltzer, Cullen, Dalbey, Denzer, Ellis, Gilmore, Hartmann, Kyte, Monier, Munro, Nilsson, Parks, Parks, Parks, Sakaguchi, Sato, Schmid, Spiess, Spiess, Spiess, Spiess, Szczesna-Skorupa, Szczesna-Skorupa, Voigt, von Heijne, von Heijne, von Heijne, von Heijne, von Heijne, Wahlberg, Walter   +31 more
core   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Deep learning for HGT insertion sites recognition

BMC Genomics, 2020
Background Horizontal Gene Transfer (HGT) refers to the sharing of genetic materials between distant species that are not in a parent-offspring relationship. The HGT insertion sites are important to understand the HGT mechanisms.
Chen Li, Jiaxing Chen, Shuai Cheng Li
doaj   +1 more source