Results 171 to 180 of about 48,752 (282)

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Infantile Spasms (West Syndrome): Integrating Genetic, Neurotrophic, and Hormonal Mechanisms Toward Precision Therapy. [PDF]

Medicina (Kaunas)
Abdygalyk B, Rabandiyarov M, Lepessova M, Koshkimbayeva G, Zharkinbekova N, Tekebayeva L, Zhailganov A, Issabekova A, Myrzaliyeva B, Tulendiyeva A, Kurmantay A, Turmanbetova A, Yerkenova S.   +12 more
europepmc   +1 more source

Gleaning the Rocky Shore? 2500 Years of Coastal Resource Use at Red Bluff 1, GunaiKurnai Country, SE Australia

Archaeology in Oceania, EarlyView.
ABSTRACT Shell middens in Gippsland along the eastern half of Victoria's coastline have usually been characterised as small, short‐duration camp sites with relatively low shell densities and low taxonomic diversity. Here we present new excavation results from a dense, high‐diversity site at Red Bluff near the eastern end of GunaiKurnai Country, a ...
Patrick Faulkner, Bruno David, David M. Kennedy, Fiona Petchey, Joanna Fresløv, Ashleigh J. Rogers, Jillian Garvey, Rachel Kirby, Runjie Yuan, Russell Mullett, John Stanisic, Kyne Krusic‐Golub, V. Ruth Pullin, Matthew C. McDowell, Robert J. Skelly, Anthony Romano, Vanessa N. L. Wong, GunaiKurnai Land and Waters Aboriginal Corporation   +17 more
wiley   +1 more source

Establishment of Interspecies Somatic Cell Nuclear Transfer and Transgene‐Free Inducible Pluripotent Stem Cells for Versatile Conservation of the Germplasm Resource of Wild Boar

Animal Research and One Health, EarlyView.
Conserving genetic material and even increasing genetic diversity is critical. To conduct the conservation of wild boar germplasm resources, we have successfully obtained healthy cloned wild boars for the first time using interspecies somatic cell nuclear transfer and established transgene‐free iPSCs that can be used to conduct iterative rounds of gene
Chen Gao, Xinyi Zhou, Shigang Gu, Jianbo Li, Jing Wang, Yurong Zhang, Wenxuan Zhao, Xinhua Wei, Liting Lu, Quanmin Zhao, Yongye Huang, Dawei Yu   +11 more
wiley   +1 more source

Capsaicin diet drives gut inflammation and exosomal miR-17-3p elevation in idiopathic short stature. [PDF]

Nat Commun
Wang Y, Wu Z, Yuan J, Zhu J, Ventin M, Arya S, Yu P, Cattaneo G, Huang G, Zhao W, Li S, Zhang J, Chen Q, Wang X, Li L, Liu X, Cheng X, Jia J.   +17 more
europepmc   +1 more source

P890: COMBINING SKY92 GENE EXPRESSION PROFILING WITH CYTOGENETICS ACCORDING TO R2-ISS FOR MULTIPLE MYELOMA RISK CLASSIFICATION: THE FIRST PROSPECTIVE EVIDENCE

HemaSphere, 2023
Xiang Zhou, Benedict Engel, Annika Hofmann, Cornelia Vogt, Silvia Nerreter, Eva Teufel, Emilia Stanojkovska, Marietta Truger, Philipp Weis, Xianghui Xiao, Florian Eisele, Christine Riedhammer, Maximilian Johannes Steinhardt, Umair Munawar, Seungbin Han, Larissa Haertle, Claudia Haferlach, Hermann Einsele, K Martin Kortum, Leo Rasche   +19 more
openaire   +2 more sources

Exploring the Roles of Tuna‐Associated Acinetobacter sp. YFT067: Implications for Host Health and Metabolism

Animal Research and One Health, EarlyView.
This study firstly isolated a tuna‐derived gut probiotic Acinetobacter seifertii YFT067. Dietary administration of YFT067 played significant roles in promoting growth performance, SCFAs production, lipid absorption, and metabolism of the host, indicating YFT067 as a promising probiotic candidate for enhancing tuna aquaculture productivity through ...
Ying Zou, Hai Huang, Qiongyao Fu, Zhiyuan Lu, Zhiqiang Guo   +4 more
wiley   +1 more source

A public resource of 15 genomically characterized representative strains of <i>Shigella sonnei</i>. [PDF]

Microb Genom
Miles SL, Hawkey J, Vezina B, Torraca V, Jenkins C, Weill FX, Baker S, Baker KS, Mostowy S, Holt KE.   +9 more
europepmc   +1 more source

P52 RISK STRATIFICATION COMBINING SKY92 GENE EXPRESSION PROFILING AND TRADITIONAL FISH IN MULTIPLE MYELOMA: THE FIRST PROSPECTIVE EVIDENCE IN THE R2-ISS ERA

HemaSphere, 2023
X. Zhou, A. Hofmann, C. Vogt, S. Nerreter, E. Teufel, E. Stanojkovska, M. Truger, B. Engel, X. Xiao, F. Eisele, P. Weis, A. Barcic, J. Peter, C. Riedhammer, M. J. Steinhardt, H. Hornburger, S. Han, L. Haertle, U. Munawar, J. Mersi, C. Haferlach, H. Einsele, K. M. Kortüm, L. Rasche   +23 more
openaire   +2 more sources

Identification of histone deacetylase inhibitor targeting type I interferon and B‐cell abnormalities in systemic lupus erythematosus

Arthritis &Rheumatology, Accepted Article.
Objective Systemic lupus erythematosus (SLE) is characterized by increased type I interferon (IFN‐I) and autoantibody production. This study aimed to identify drugs that can inhibit both IFN‐I and autoantibody production. Methods We identified an inhibitor of IFN‐I production from a chemical library.
Takehiro Hirayama, Hachiro Konaka, Yasuhiro Kato, Takayuki Shibahara, Chisato Nishizawa, Kohei Tsujimoto, JeongHoon Park, Eri Itotagawa, Tatsunori Jo, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Wataru Aoki, Ken J Ishii, Hyota Takamatsu, Atsushi Kumanogoh   +16 more
wiley   +1 more source