Inhibition of MAPK-Erk pathway in vivo attenuates aortic valve disease processes in Emilin1-deficient mouse model [PDF]
, 2017 Aortic valve disease (AVD) is a common condition with a progressive natural history, and presently, there are no pharmacologic treatment strategies. Elastic fiber fragmentation (EFF) is a hallmark of AVD, and increasing evidence implicates developmental ...
Aikawa +45 more
core +2 more sources
A novel platform for the production of nonhydroxylated gelatins based on the methylotrophic yeast Hansenula polymorpha [PDF]
, 2007 The use of yeast as a host for heterologous expression of proteins that are normally derived from animal tissue is a promising way to ensure defined products that are devoid of potential harmful animal side products.
Boer, Arjo L. de, +4 more
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Biofilm formation among methicillin-resistant Staphylococcus aureus isolates from patients with urinary tract infection. [PDF]
, 2004 Staphylococci have been confirmed to form biofilms on various biomaterials. The purpose of this study was to investigate biofilm formation among methicillin-resistant Staphylococcus aureus (MRSA) isolates from patients with urinary tract infection (UTI ...
Ando, Eiichi +4 more
core +1 more source
Molecular Genetics & Genomic Medicine, 2021 Objective We determined the yield, genetic spectrum, and actual origin of de novo mutations (DNMs) for infantile spasms (ISs) in a Chinese cohort. The efficacy of levetiracetam (LEV) for STXBP1‐related ISs was explored also.
Liying Liu +12 more
doaj +1 more source
PPARα contributes to protection against metabolic and inflammatory derangements associated with acute kidney injury in experimental sepsis [PDF]
, 2019 Sepsis‐associated acute kidney injury (AKI) is a significant problem in critically ill children and adults resulting in increased morbidity and mortality. Fundamental mechanisms contributing to sepsis‐associated AKI are poorly understood.
Bennion, Brock G +10 more
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Annals of Medicine, 2021 Background The response rate and survival benefit of immunotherapy vary among patients, implying specific immune status of an individual could be associated with the effect of immunotherapy.
Yujie Xie +6 more
doaj +1 more source
Sorogrupos e genes de virulência em Escherichia coli isoladas de psitacídeos [PDF]
, 2011 Escherichia coli isolates from 24 sick psittacine birds were serogrouped and investigated for the presence of genes encoding the following virulence factors: attaching and effacing (eae), enteropathogenic E.
Blanco, Jesus e +7 more
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Occurrence of pathogenic and faecal Escherichia coli in layer hens
Italian Journal of Animal Science, 2010 A total of 117 Escherichia coli from colibacillosis affected (APEC) and clinically healthy birds (AFEC) were serotyped and tested for the presence of virulence genes: iss, tsh, cva. A total of 54.5% E.
Silvia Tagliabue +6 more
doaj +1 more source
Idiopathic Short Stature: What to Expect from Genomic Investigations
Endocrines, 2023 Short stature is a common concern for physicians caring for children. In traditional investigations, about 70% of children are healthy, without producing clinical and laboratory findings that justify their growth disorder, being classified as having ...
Nathalia Liberatoscioli Menezes Andrade +4 more
doaj +1 more source
Expression and intracellular localization of FKHRL1 in mammary gland neoplasms. [PDF]
, 2004 FKHRL1 (FOXO3a), a member of the Forkhead family of genes, has been considered to be involved in the development of breast tumors; however, the in vivo expression and activation status of FKHRL1 in breast tumors still remains unclear.
Akagi, Tadaatsu +8 more
core +1 more source