Results 11 to 20 of about 84,890 (266)

Estimation of genetic admixture proportions via haplotypes. [PDF]

Comput Struct Biotechnol J, 2023
AbstractEstimation of ethnic admixture is essential for creating personal genealogies, studying human history, and conducting genome-wide association studies (GWAS). Three methods exist for estimating admixture coefficients. The frequentist approach directly maximizes the binomial loglikelihood. The Bayesian approach adds a reasonable prior and samples
Ko S, Sobel EM, Zhou H, Lange K.
europepmc   +6 more sources

Complex genetic admixture histories reconstructed with Approximate Bayesian Computation. [PDF]

Mol Ecol Resour, 2021
ABSTRACTAdmixture is a fundamental evolutionary process that has influenced genetic patterns in numerous species. Maximum-likelihood approaches based on allele frequencies and linkage-disequilibrium have been extensively used to infer admixture processes from dense genome-wide datasets mostly in human populations.
Fortes-Lima CA, Laurent R, Thouzeau V, Toupance B, Verdu P.   +4 more
europepmc   +7 more sources

Heterogeneity of Genetic Admixture Determines SLE Susceptibility in Mexican. [PDF]

Front Genet, 2021
Systemic Lupus Erythematosus (SLE) is an autoimmune inflammatory disorder for which Major Histocompatibility Complex (MHC) genes are well identified as risk factors. SLE patients present different clinical phenotypes, which are partly explained by admixture patterns variation among Mexicans.
Hernández-Doño S, Jakez-Ocampo J, Márquez-García JE, Ruiz D, Acuña-Alonzo V, Lima G, Llorente L, Tovar-Méndez VH, García-Silva R, Granados J, Zúñiga J, Vargas-Alarcón G.   +11 more
europepmc   +5 more sources

Human genetic admixture through the lens of population genomics. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2022
Over the past 50 years, geneticists have made great strides in understanding how our species' evolutionary history gave rise to current patterns of human genetic diversity classically summarized by Lewontin in his 1972 paper, ‘The Apportionment of Human Diversity’. One evolutionary process that requires special attention in both population genetics and
Gopalan S, Smith SP, Korunes K, Hamid I, Ramachandran S, Goldberg A.   +5 more
europepmc   +4 more sources

Fine-Scale Genetic Structure and Natural Selection Signatures of Southwestern Hans Inferred From Patterns of Genome-Wide Allele, Haplotype, and Haplogroup Lineages

Frontiers in Genetics, 2021
The evolutionary and admixture history of Han Chinese have been widely discussed via traditional autosomal and uniparental genetic markers [e.g., short tandem repeats, low-density single nucleotide polymorphisms).
Mengge Wang, Mengge Wang, Didi Yuan, Xing Zou, Zheng Wang, Hui-Yuan Yeh, Jing Liu, Lan-Hai Wei, Chuan-Chao Wang, Bofeng Zhu, Bofeng Zhu, Bofeng Zhu, Chao Liu, Chao Liu, Chao Liu, Guanglin He, Guanglin He   +16 more
doaj   +1 more source

A Genetic Atlas of Human Admixture History [PDF]

Science, 2014
Evidence of human migrations over the past 4000 years is identified in existing genomes.
Hellenthal G, Busby GBJ, Band G, Wilson JF, Capelli C, Falush D, Myers S   +6 more
openaire   +6 more sources

Evolutionary Genetics and Admixture in African Populations

Genome Biology and Evolution, 2023
Abstract As the ancestral homeland of our species, Africa contains elevated levels of genetic diversity and substantial population structure. Importantly, African genomes are heterogeneous: They contain mixtures of multiple ancestries, each of which have experienced different evolutionary histories.
Aaron Pfennig, Lindsay N Petersen, Paidamoyo Kachambwa, Joseph Lachance   +3 more
openaire   +2 more sources

Genomic Insights Into the Admixture History of Mongolic- and Tungusic-Speaking Populations From Southwestern East Asia

Frontiers in Genetics, 2021
As a major part of the modern Trans-Eurasian or Altaic language family, most of the Mongolic and Tungusic languages were mainly spoken in northern China, Mongolia, and southern Siberia, but some were also found in southern China. Previous genetic surveys
Jing Chen, Guanglin He, Zheng Ren, Qiyan Wang, Yubo Liu, Hongling Zhang, Meiqing Yang, Han Zhang, Jingyan Ji, Jing Zhao, Jianxin Guo, Kongyang Zhu, Xiaomin Yang, Rui Wang, Hao Ma, Chuan-Chao Wang, Chuan-Chao Wang, Jiang Huang   +17 more
doaj   +1 more source

Evaluation of group genetic ancestry of populations from Philadelphia and Dakar in the context of sex-biased admixture in the Americas. [PDF]

PLoS ONE, 2009
Population history can be reflected in group genetic ancestry, where genomic variation captured by the mitochondrial DNA (mtDNA) and non-recombining portion of the Y chromosome (NRY) can separate female- and male-specific admixture processes.
Klara Stefflova, Matthew C Dulik, Athma A Pai, Amy H Walker, Charnita M Zeigler-Johnson, Serigne M Gueye, Theodore G Schurr, Timothy R Rebbeck   +7 more
doaj   +1 more source

Genetic evidence for archaic admixture in Africa [PDF]

Proceedings of the National Academy of Sciences, 2011
A long-debated question concerns the fate of archaic forms of the genus Homo : did they go extinct without interbreeding with anatomically modern humans, or are their genes present in contemporary populations? This question is typically focused on the genetic contribution of archaic forms outside of Africa.
Michael F, Hammer, August E, Woerner, Fernando L, Mendez, Joseph C, Watkins, Jeffrey D, Wall   +4 more
openaire   +2 more sources