Results 51 to 60 of about 538,821 (309)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

A GPU accelerated hybrid GA-SVM for large scale datasets: Cu-GA-SVM

open access: yesGazi Üniversitesi Fen Bilimleri Dergisi, 2018
In this study, CUDA based speed optimization of a hybrid method consisting of Genetic Algorithm and Support Vector Machines has been performed. In machine learning, it is aimed to achieve high accuracy values from the developed methods.
Musa PEKER, Osman ÖZKARACA
doaj   +1 more source

Genetic algorithm designed for optimization of neural network architectures for intracranial EEG recordings analysis [PDF]

open access: hybrid, 2023
Kristyna Pijackova   +10 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

ROBUST-HYBRID GENETIC ALGORITHM FOR A FLOW-SHOP SCHEDULING PROBLEM (A Case Study at PT FSCM Manufacturing Indonesia)

open access: yesJurnal Teknik Industri, 2007
This paper discusses the application of Robust Hybrid Genetic Algorithm to solve a flow-shop scheduling problem. The proposed algorithm attempted to reach minimum makespan. PT.
Johan Soewanda   +2 more
doaj  

A Survey of Identification Experimental System Parameters Using Genetic Algorithm [PDF]

open access: yesRobotica & Management
System parameter identification is the process of finding system parameters to convert physical control signals (usually torque) from theoretical controllers into signals that the hardware can generate for communication connected to model’s executive ...
Trong-Bang Tran   +7 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Predictive Model for End Aim Temperature of Arc Furnace Based on Hybrid Genetic Algorithm

open access: yesTeshugang, 2007
BP ( Back Propagation) algorithm and genetic algorithm are combined into hybrid genetic algorithm of which the algorithm steps are first to locate a favorable searching region by genetic algorithm, then to search optimal coefficients in the located ...
Jiang Jing, Li Huade, Sun Tie, Jiang Lin
doaj  

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